A5077771417- Spaceflight effects on biology
- Space Exploration and Technology
- Spacecraft Design and Technology
- Planetary Science and Exploration
- RNA Interference and Gene Delivery
- Advanced Sensor and Energy Harvesting Materials
- Astro and Planetary Science
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Interactive and Immersive Displays
- Bacteriophages and microbial interactions
- Cardiac Arrest and Resuscitation
- Biomedical and Engineering Education
- Technology Assessment and Management
- Conducting polymers and applications
- Light effects on plants
- Military Strategy and Technology
- Space Science and Extraterrestrial Life
- Systems Engineering Methodologies and Applications
- Analytical Chemistry and Sensors
- Fish biology, ecology, and behavior
- High Altitude and Hypoxia
- Genetics, Bioinformatics, and Biomedical Research
- Heart Rate Variability and Autonomic Control
- thermodynamics and calorimetric analyses
Alberta Health Services
2024
Alberta Hospital Edmonton
2024
University of Alberta Hospital
2024
Ames Research Center
2007-2021
BioElectronics (United States)
2019-2020
University of California, Los Angeles
2019-2020
Tanabe Research Laboratories
2019
University of California, Davis
2013
Griffith University
2012
University of San Francisco
2005
Recent advances in microelectronics, microfluidics, and electrochemical sensing platforms have enabled the development of an emerging class fully integrated personal health monitoring devices that exploit sweat to noninvasively access biomarker information. Despite such advances, effective sampling remains a significant challenge for reliable analysis, with many existing methods requiring active stimulation (e.g., iontophoresis, exercise, heat). Natural perspiration offers suitable...
We report the first telemetered spaceflight science results from orbiting Space Environment Survivability of Living Organisms (SESLO) experiment, executed by one two 10 cm cube-format payloads aboard 5.5 kg Organism/Organic Exposure to Orbital Stresses (O/OREOS) free-flying nanosatellite. The O/OREOS spacecraft was launched successfully a 72° inclination, 650 km Earth orbit on 19 November 2010. This satellite provides access radiation environment space in relatively weak regions Earth's...
Spaceflight uniquely alters the physiology of both human cells and microbial pathogens, stimulating cellular molecular changes directly relevant to infectious disease. However, influence this environment on host-pathogen interactions remains poorly understood. Here we report our results from STL-IMMUNE study flown aboard Space Shuttle mission STS-131, which investigated multi-omic responses (transcriptomic, proteomic) intestinal epithelial infection with Salmonella Typhimurium when host...
We designed, built, tested, space-qualified, launched, and downlinked bioanalytical data from a fully autonomous free-flying space satellite that supports microorganism growth in multiple fluidic wells monitors gene expression via fluorescence. GeneSat-1 (total mass: 4.4 kg) includes solar cells, integrated spacecraft "bus" module (power/batteries/control/bi-directional communications), an insulated pressure vessel housing the biofluidic, optical, thermal, sensor subsystems. Data were...
Short interfering RNAs (siRNAs) are promising drug candidates for a wide range of targets including those previously considered "undruggable". However, properties associated with the native RNA structure limit development, and chemical modifications necessary. Here we describe structure-guided discovery functional guide strand 5′-end using computational screening high-resolution human Ago2, key nuclease on interference pathway. Our results indicate nucleotide need not engage in Watson–Crick...
We designed, built, tested, space-qualified, launched, and collected telemetered data from low Earth orbit Pharma- Sat, a 5.1-kg free flying "nanosatellite" that supported microbial growth in 48 microfluidic wells, dosed microbes with multiple concentrations of pharmaceutical agent, monitored metabolic activity using dedicated 3-color optical absorbance system at each microwell. The PharmaSat nanosatellite comprised structure approximately 10 x 35 cm, including triple-junction solar cells,...
We designed, built, tested, space-qualified, launched, and downlinked bioanalytical data from PharmaSat, the first fully autonomous outer-space pharmaceutical dose-response system on a free-flying satellite.PharmaSat tracks microorganism culture population density metabolic activity in 48 microwells via 3-color optical absorbance.Its 5.1-kg total mass includes solar cells, integrated spacecraft "bus" module (power/batteries/ control/communications), sealed containment vessel housing...
Voltammetry-based sensing systems are suitable for wearable monitoring of electroactive biomarkers in epidermally-retrievable biofluids (e.g., sweat), as they can directly transduce the redox features targets into electrical signals, delivering a sample-to-answer solution. To render reliable voltammetric readouts, fundamental challenge biofluid-induced fouling (causing rapid and irreversible signal degradation) must be addressed-an issue which has been overlooked previously reported sensor...
We designed, developed, constructed, tested, launched, and are now analyzing data telemetered from orbit by the O/OREOS (Organism/ Organic Exposure to Orbital Stresses) nanosatellite.Measuring ~10 x 10 34 cm weighing 5.5 kg, (Figure 1) launched in November 2010 into 650-km Earth as a secondary payload Kodiak, Alaska.O/OREOS comprises three conjoined 10-cm-cubes, each fully integrated microsystem: "bus" including communications, power, control functions; Space Environment Survivability of...
cMet is a well-characterized oncogene that the target of many drugs including small molecule and biologic pathway inhibitors, more recently, antibody drug conjugates (ADCs). However, clinical benefit from c-Met targeted therapy has been limited up to this point. We developed an optimized conjugate TR1801-ADC utilized optimization at all steps specificity, stability, internalization, toxin linkers, conjugation site, PK, in vivo efficacy. The results were highly potent ADC was superior...