A5055337948- Dementia and Cognitive Impairment Research
- Sleep and related disorders
- Nutritional Studies and Diet
- Alzheimer's disease research and treatments
- Health disparities and outcomes
- Health, Environment, Cognitive Aging
- Traumatic Brain Injury Research
- Sleep and Wakefulness Research
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Risk Factors
- Frailty in Older Adults
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Diet and metabolism studies
- Cardiovascular Health and Disease Prevention
- Obstructive Sleep Apnea Research
- Cardiac Arrest and Resuscitation
- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- Health Systems, Economic Evaluations, Quality of Life
- Geriatric Care and Nursing Homes
- Nutrition and Health in Aging
- Functional Brain Connectivity Studies
- Aging and Gerontology Research
- Neurological Disease Mechanisms and Treatments
San Francisco VA Medical Center
2016-2025
University of California, San Francisco
2016-2025
San Francisco VA Health Care System
2016-2025
City College of San Francisco
2012-2025
Global Brain Health Institute
2017-2025
University of St. Francis
2009-2025
Northern California Institute for Research and Education
2014-2024
National Institute on Aging
2009-2024
University of Michigan
2008-2024
University of Minnesota
2006-2024
The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years before the diagnosis AD dementia. This long “preclinical” phase would provide a critical opportunity for therapeutic intervention; however, we need further elucidate link between pathological cascade and emergence clinical symptoms. National Institute on Aging Association convened an international workgroup review biomarker, epidemiological, neuropsychological evidence, develop recommendations determine...
The American Heart Association, in conjunction with the National Institutes of Health, annually reports most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, weight) factors (cholesterol, blood pressure, glucose control) that contribute health. Statistical Update presents latest data on a range major clinical circulatory disease conditions (including congenital rhythm disorders,...
Background:Whetherhearinglossisindependentlyassociatedwithacceleratedcognitivedeclineinolderadults is unknown. Methods:Westudied1984olderadults(meanage,77.4 years) enrolled in the Health ABC Study, a prospective observational study begun 1997-1998. Our baseline cohort consisted of participants without prevalent cognitive impairment (Modified Mini-Mental State Examination [3MS] score, 80) who underwent audiometric testinginyear5.Participantswerefollowedupfor6years. Hearing was defined at...
To evaluate if midlife cardiovascular risk factors are associated with of late-life dementia in a large, diverse cohort.The authors conducted retrospective cohort study 8,845 participants health maintenance organization who underwent evaluations from 1964 to 1973 when they were between the ages 40 and 44. Midlife included total cholesterol, diabetes, hypertension, smoking. Diagnoses ascertained by medical records January 1994 April 2003.The identified 721 (8.2%) dementia. Smoking, high...
Although acute hypoglycemia may be associated with cognitive impairment in children type 1 diabetes, no studies to date have evaluated whether is a risk factor for dementia older patients 2 diabetes.To determine if hypoglycemic episodes severe enough require hospitalization are an increased of population diabetes followed up 27 years.A longitudinal cohort study from 1980-2007 16,667 mean age 65 years and who members integrated health care delivery system northern California.Hypoglycemic...
To evaluate any association between obesity in middle age, measured by body mass index and skinfold thickness, risk of dementia later life.Analysis prospective data from a multiethnic population based cohort.Kaiser Permanente Northern California Medical Group, healthcare delivery organisation.10,276 men women who underwent detailed health evaluations 1964 to 1973 when they were aged 40-45 still members the plan 1994.Diagnosis January 1994 April 2003. Time diagnosis was analysed with Cox...
<h3>Context</h3>Sleep-disordered breathing (characterized by recurrent arousals from sleep and intermittent hypoxemia) is common among older adults. Cross-sectional studies have linked sleep-disordered to poor cognition; however, it remains unclear whether precedes cognitive impairment in adults.<h3>Objectives</h3>To determine the prospective relationship between investigate potential mechanisms of this association.<h3>Design, Setting, Participants</h3>Prospective cognition study 298 women...
ContextSeveral studies have reported an association between the metabolic syndrome and cardiovascular disease. Despite increasing awareness that risk factors increase of cognitive decline dementia, there are few data on cognition.ObjectiveTo determine if is a factor for this modified by inflammation.Design SettingA 5-year prospective observational study conducted from 1997 to 2002 at community clinics 2 sites.ParticipantsA total 2632 black white elders (mean age, 74 years).Main Outcome...
It is unclear whether functional status before dialysis maintained after the initiation of this therapy in elderly patients with end-stage renal disease (ESRD).Using a national registry undergoing dialysis, which was linked to nursing home residents, we identified all 3702 residents United States who were starting treatment between June 1998 and October 2000 for whom at least one measurement available dialysis. Functional measured by assessing degree dependence seven activities daily living...
<h3>Background</h3> Several studies have suggested that physical activity is positively associated with cognitive function in elderly persons. Evidence about this association has been limited by the cross-sectional design of most and frequent lack adjustment for potential confounding variables. We determined whether decline a prospective study older women. <h3>Methods</h3> studied 5925 predominantly white community-dwelling women (aged ≥65 years) who were recruited at 4 clinical centers...
The decision to institutionalize a patient with dementia is complex and based on caregiver characteristics the sociocultural context of patients caregivers. Most studies have determined predictors nursing home placement primarily according or alone.To develop validate prognostic model determine comprehensive among an ethnically diverse population dementia.The Medicare Alzheimer's Disease Demonstration Evaluation study, prospective study at 8 sites in United States, enrollment between...
To investigate the efficacy of a novel brain plasticity-based computerized cognitive training program in older adults and to evaluate effect on untrained measures memory attention participant-reported outcomes.
<h3>Context</h3> Little is known about prevalence rates of<i>DSM-IV</i>disorders across age strata of older adults, including common conditions such as individual and coexisting mood anxiety disorders. <h3>Objective</h3> To determine nationally representative estimates 12-month mood, anxiety, comorbid mood-anxiety disorders young-old, mid-old, old-old, oldest-old community-dwelling adults. <h3>Design</h3> The National Comorbidity Survey Replication (NCS-R) a population-based probability...
Several lines of evidence suggest that inflammatory mechanisms contribute to AD.To examine whether several markers inflammation are associated with cognitive decline in African-American and white well-functioning elders.The authors studied 3,031 men women (mean age 74 years) enrolled the Health, Aging, Body Composition Study. Serum levels interleukin-6 (IL-6) C-reactive protein (CRP) plasma tumor necrosis factor-alpha (TNFalpha) were measured at baseline; cognition was assessed Modified...