A5059731976- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Neural and Behavioral Psychology Studies
- Aging and Gerontology Research
- Face Recognition and Perception
- Memory and Neural Mechanisms
- Memory Processes and Influences
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Cognitive Functions and Memory
- Advanced MRI Techniques and Applications
- Cognitive Abilities and Testing
- Neurobiology of Language and Bilingualism
- Visual perception and processing mechanisms
- Cultural Differences and Values
- Neural dynamics and brain function
- Behavioral Health and Interventions
- Health and Well-being Studies
- Child and Animal Learning Development
- Categorization, perception, and language
- EEG and Brain-Computer Interfaces
- Cognitive Science and Mapping
- Mental Health Research Topics
- Health, Environment, Cognitive Aging
- Health Literacy and Information Accessibility
The University of Texas at Dallas
2016-2025
The University of Texas Southwestern Medical Center
2013-2025
Advanced Imaging Research (United States)
2021
Johns Hopkins University
2021
University of Kentucky
2020
University Hospital Cologne
2016
Southwestern Medical Center
2013-2014
University of Illinois Urbana-Champaign
2002-2011
Duke-NUS Medical School
2011
Nagoya University
2010
The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years before the diagnosis AD dementia. This long “preclinical” phase would provide a critical opportunity for therapeutic intervention; however, we need further elucidate link between pathological cascade and emergence clinical symptoms. National Institute on Aging Association convened an international workgroup review biomarker, epidemiological, neuropsychological evidence, develop recommendations determine...
The authors investigated the distinctiveness and interrelationships among visuospatial verbal memory processes in short-term, working, long-term memories 345 adults. Beginning 20s, a continuous, regular decline occurs for processing-intensive tasks (e.g., speed of processing, working memory, memory), whereas knowledge increases across life span. There is little differentiation cognitive architecture Visuospatial are distinct but highly interrelated systems with domain-specific short-term...
Healthy aging has been associated with decreased specialization in brain function. This characterization focused largely on describing age-accompanied differences at the level of neurons and areas. We expand this work to describe systems-level a healthy adult lifespan sample (n = 210; 20-89 y). A graph-theoretic framework is used guide analysis functional MRI resting-state data connectivity individual networks. Young adults' systems exhibit balance within- between-system correlations that...
The present study investigated whether neural structures become less functionally differentiated and specialized with age. We studied ventral visual cortex, an area of the brain that responds selectively to categories (faces, places, words) in young adults, shows little atrophy Functional MRI was used estimate activity this cortical area, while old adults viewed faces, houses, pseudowords, chairs. results demonstrated significantly specialization for these stimulus older across a range analyses.
Abstract We investigated the hypothesis that increased prefrontal activations in older adults are compensatory for decreases medial-temporal occur with age. Because scene encoding engages both hippocampal and sites, we examined incidental of scenes by 14 young 13 a subsequent memory paradigm using functional magnetic resonance imaging (fMRI). Behavioral results indicated there were equivalent numbers remembered forgotten items, which did not vary as function In an fMRI analysis subtracting...
Is it possible to enhance neural and cognitive function with training techniques? Can we delay age-related decline in interventions stave off Alzheimer's disease? Does an aged brain really have the capacity change response stimulation? In present paper, consider neuroplasticity of aging brain, that is, brain's ability increase sustained experience. We argue that, although there is some deterioration occurs age, has activity develop scaffolding regulate function. suggest volume or experience...
In the research reported here, we tested hypothesis that sustained engagement in learning new skills activated working memory, episodic and reasoning over a period of 3 months would enhance cognitive function older adults. three conditions with high demands, participants learned to quilt, digital photography, or engaged both activities for an average 16.51 hr week months. Results at posttest indicated memory was enhanced these productive-engagement relative receptive-engagement conditions,...
With age, the brain undergoes comprehensive changes in its function and physiology. Cerebral metabolism blood supply are among key physiologic processes supporting daily of may play an important role age-related cognitive decline. Using MRI, it is now possible to make quantitative assessment these parameters a noninvasive manner. In present study, we concurrently measured cerebral metabolic rate oxygen (CMRO(2)), flow (CBF), venous oxygenation well-characterized healthy adult cohort from 20...
It is well documented that aging associated with cognitive declines in many domains. Yet it a common lay belief some aspects of thinking improve into old age. Specifically, older people are believed to show better competencies for reasoning about social dilemmas and conflicts. Moreover, the idea aging-related gains wisdom consistent views mind developmental psychology. However, date research has provided little evidence corroborating this assumption. We addressed question two studies, using...
<h3>Importance</h3>Identifying risk factors for increased β-amyloid (Aβ) deposition is important targeting individuals most at developing Alzheimer disease and informing clinical practice concerning prevention early detection.<h3>Objective</h3>To investigate Aβ in cognitively healthy middle-aged older adults. Specifically, we hypothesized that with a vascular factor such as hypertension, combination genetic (apolipoprotein E ϵ4 allele), would show greater amyloid burden than those without...
Purpose of the Study:Recent evidence shows that engaging in learning new skills improves episodic memory older adults. In this study, adults who were computer novices trained to use a tablet and associated software applications. We hypothesize sustained engagement mentally challenging training would yield dual benefit improved cognition enhancement everyday function by introducing useful skills.
Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it unknown whether continuous age- AD-related cortical degradation alters asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order regions exhibiting pronounced at age ~20 also asymmetry-loss across lifespan. Hence, accelerated thinning (previously) thicker homotopic hemisphere a aging. This...
Objective.To evaluate fibromyalgia (FM) patients for the presence of cognitive deficits and to test hypothesis that abnormalities would fit a model aging.Methods.We studied 3 groups patients: FM without concomitant depression in absence medications known affect function (n ؍ 23), age-and education-matched controls older who were individually matched be 20 years (؎3 years) than 22).We measured speed information processing, working memory function, free recall, recognition memory, verbal...
Telling people that a consumer claim is false can make them misremember it as true. In two experiments older adults were especially susceptible to this illusion of truth effect. Repeatedly identifying helped remember in the short term, but paradoxically made more likely true after three-day delay. This unintended effect repetition comes from increased familiarity with itself, decreased recollection claim's original context. Findings provide insight into susceptibility over time memory...
The magnitude of age differences on event- and time-based prospective memory tasks was investigated in 2 experiments. Participants performed a working task were also required to perform either an or action. Control participants the only only. Results yielded both tasks. effect particularly marked task. Performance event-based task, however, had higher cost performance concurrent than did, suggesting that responding has substantial attentional requirement. older adults made significant number...