A5017855145- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Health, Environment, Cognitive Aging
- Inflammatory Bowel Disease
- Microscopic Colitis
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Bioinformatics and Genomic Networks
- Tryptophan and brain disorders
- Metabolomics and Mass Spectrometry Studies
- Helicobacter pylori-related gastroenterology studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Imaging Techniques and Applications
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Frailty in Older Adults
- Sleep and related disorders
- Advanced Proteomics Techniques and Applications
- Folate and B Vitamins Research
- Neurological Disease Mechanisms and Treatments
- S100 Proteins and Annexins
- GDF15 and Related Biomarkers
- Neonatal and fetal brain pathology
- Cancer-related Molecular Pathways
Australian e-Health Research Centre
2016-2025
CSIRO Health and Biosecurity
2016-2025
Commonwealth Scientific and Industrial Research Organisation
2016-2025
Edith Cowan University
2022-2024
Royal Brisbane and Women's Hospital
2014-2024
Landscape Research Group
2023
Authorised Association Consortium
2023
Health Sciences and Nutrition
2016-2023
Queensland Health
2021
The University of Queensland
2008-2021
OBJECTIVES: Despite increased prescription of a gluten-free diet for gastrointestinal symptoms in individuals who do not have celiac disease, there is minimal evidence that suggests gluten trigger. The aims this study were to determine whether ingestion can induce non-celiac and examine the mechanism. METHODS: A double-blind, randomized, placebo-controlled rechallenge trial was undertaken patients with irritable bowel syndrome whom disease excluded symptomatically controlled on diet....
Objective: To identify plasma biomarkers for the diagnosis of Alzheimer disease (AD).Design: Baseline screening 151 multiplexed analytes combined with targeted biomarker and clinical pathology data.Setting: General community-based, prospective
Diagnosis of the autoimmune disease type 1 diabetes (T1D) is preceded by appearance circulating autoantibodies to pancreatic islets. However, almost nothing known about events leading this islet autoimmunity. Previous epidemiological and genetic data have associated viral infections antiviral I interferon (IFN) immune response genes with T1D. Here, we first used DNA microarray analysis identify IFN-β-inducible in vitro then set define an IFN-inducible transcriptional signature peripheral...
Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer's disease (LOAD). However, LOAD genetic architecture and prediction are unclear. Here we estimate the optimal P-threshold (P
See Derry and Kent (doi:10.1093/awx167) for a scientific commentary on this article.The large variance in cognitive deterioration subjects who test positive amyloid-β by positron emission tomography indicates that convergent pathologies, such as iron accumulation, might combine with to accelerate Alzheimer's disease progression. Here, we applied quantitative susceptibility mapping, relatively new magnetic resonance imaging method sensitive tissue iron, assess the relationship between load,...
Plasma amyloid beta (Aβ)1-42/Aβ1-40 ratio, phosphorylated-tau181 (p-tau181), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) are putative blood biomarkers for Alzheimer's disease (AD). However, head-to-head cross-sectional longitudinal comparisons of the aforementioned across AD continuum lacking.Plasma Aβ1-42, Aβ1-40, p-tau181, GFAP, NfL were measured utilizing Single Molecule Array (Simoa) platform compared cross-sectionally continuum, wherein Aβ-PET (positron...
<h3>Objective</h3> To explore whether the plasma total β-amyloid (Aβ) Aβ<sub>42</sub>/Aβ<sub>40</sub> ratio is a reliable predictor of amyloid-PET status by exploring association between these 2 variables in subset Australian Imaging, Biomarkers and Lifestyle (AIBL) study aging cohort. <h3>Methods</h3> Taking samples at 3 separate time points, month 18 (n = 176), 36 169), 54 135), we assessed (TP42/40) with regard to neocortical Aβ burden via PET standardized uptake value (SUVR) investigated...
Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it unknown whether continuous age- AD-related cortical degradation alters asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order regions exhibiting pronounced at age ~20 also asymmetry-loss across lifespan. Hence, accelerated thinning (previously) thicker homotopic hemisphere a aging. This...
The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), 211 Alzheimer's disease dementia (AD)) an 'Inception cohort' who underwent detailed ssessments every 18 months. Over the past decade, additional 1247 subjects have been added 'Enrichment (as 10 April 2019). Here we provide overview these Inception Enrichment cohorts more than 8,500 person-years...
<h3>Abstract</h3> <h3>Objective</h3> To compare prenatal care providers’ perceived self-efficacy in starting discussions about gestational weight gain with pregnant women under a variety of conditions gradated difficulty, when has been excess current guidelines. <h3>Design</h3> A 42-item online questionnaire related to the known barriers and facilitators having gain. <h3>Setting</h3> Canada. <h3>Participants</h3> Prenatal providers were contacted through Family Medicine Maternity Care list...
Abstract Introduction Plasma amyloid β (Aβ) peptides have been previously studied as candidate biomarkers to increase recruitment efficiency in secondary prevention clinical trials for Alzheimer's disease. Methods Free and total Aβ42/40 plasma ratios (FP42/40 TP42/40, respectively) were determined using ABtest assays cognitively normal subjects from the Australian Imaging, Biomarker Lifestyle Flagship Study. This population was followed‐up 72 months their cortical Aβ burden assessed with...
We fractionated frontal cortical grey matter from human Alzheimer's disease and control subjects into four biochemically defined pools that represent distinct compartments: soluble/cytosolic, peripheral membrane/vesicular cargo, integral lipid/membranous aggregated/insoluble debris. Most of the readily extractable amyloid-β remains associated with a compartment. There is an exchange between biochemical was lost for amyloid-β42 species in disease, consistent peptide being irreversibly trapped...
Importance The ability to predict the onset of mild cognitive impairment (MCI) and Alzheimer dementia (AD) could allow older adults clinicians make informed decisions about care. Objective To assess whether age at MCI AD can be predicted using a statistical modeling approach. Design, Setting, Participants This prognostic study used data from 2 aging cohort studies—the Australian Imaging, Biomarker Lifestyle (AIBL) Alzheimer’s Disease Neuroimaging Initiative (ADNI)—for model development...
Abstract Cholestatic liver diseases, such as cystic fibrosis (CF) disease and biliary atresia, predominate causes of childhood cirrhosis. Despite diverse etiologies, the stereotypic final pathway involves fibrogenesis where hepatic stellate cells (HSCs) are recruited, producing excess collagen which initiates fibrosis. A possible molecular determinant this recruitment, monocyte chemotaxis protein-1 (MCP-1), an HSC-responsive chemokine, was investigated in CF atresia. The bile-duct-ligated...
Background Up to 40% of patients who present with acute severe ulcerative colitis (UC) fail make an adequate response intravenous corticosteroids. Ciclosporin or infliximab are currently employed as salvage therapy in this clinical scenario. Aim To compare outcomes treated ciclosporin the setting steroid-refractory UC. Methods A prospective study 83 consecutive presentations UC from 1999 2009 was conducted. All participants satisfied Truelove and Witts' criteria for The primary outcome...
This randomised, double-blind, placebo-controlled trial assessed the efficacy and tolerability of pregabalin to alleviate neuropathic component moderate severe burn pain. Patients aged 18 65 years admitted a burns unit with 5% or greater total body surface area injury were screened participate in trial. Using Neuropathic Pain Scale (NPS), patients scoring 4 higher on 'hot' pain 'sharp' invited participate. Consenting randomly assigned receive placebo for 28 days individual dose titration...
Total tau (tTau) and phosphorylated 181P (pTau) are supportive diagnostic cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease. Manual CSF assays limited by lot-to-lot between-laboratory variability long incubation/turnaround times. Elecsys® Total-Tau Phospho-Tau (181P) immunoassays were developed fully automated cobas e analyzers, allowing broader access in clinical practice trials.Analytical performance, reproducibility, method comparisons with commercially available assays,...