A5073327600- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Nuclear Receptors and Signaling
- Memory and Neural Mechanisms
- HER2/EGFR in Cancer Research
- Glioma Diagnosis and Treatment
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Bone Tumor Diagnosis and Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Cancer Cells and Metastasis
- Mitochondrial Function and Pathology
- Cerebral Palsy and Movement Disorders
- Sarcoma Diagnosis and Treatment
- Neural dynamics and brain function
- Brain Metastases and Treatment
Wake Forest University
2022-2025
The University of Texas at Dallas
2021-2022
The University of Texas Southwestern Medical Center
2018-2021
Johns Hopkins University
2021
Advanced Imaging Research (United States)
2021
South Texas Accelerated Research Therapeutics
2016-2019
Clinical Trials of Texas
2018
Dartmouth College
2014-2018
Dartmouth–Hitchcock Medical Center
2013
University College London
2013
The recently discovered default mode network (DMN) is a group of areas in the human brain characterized, collectively, by functions self-referential nature. In normal individuals, activity DMN reduced during nonself-referential goal-directed tasks, keeping with folk-psychological notion losing one's self work. Imaging and anatomical studies major depression have found alterations both structure function some regions that belong to DMN, thus, suggesting basis for disordered thought...
Aerobic glycolysis is defined as glucose utilization in excess of that used for oxidative phosphorylation despite sufficient oxygen to completely metabolize carbon dioxide and water. present the normal human brain at rest increases locally during increased neuronal activity; yet its many biological functions have received scant attention because a prevailing energy-centric focus on role substrate phosphorylation. As an initial step redressing this neglect, we measured regional distribution...
We investigated whether interictal epileptiform discharges (IED) in the human hippocampus are related to impairment of specific memory processes, and which characteristics hippocampal IED most associated with dysfunction.Ten patients had depth electrodes implanted into their hippocampi for preoperative seizure localization. EEG was recorded during 2,070 total trials a short-term task, processing categorized encoding, maintenance, retrieval. The influence on these processes analyzed adjusted...
Aging and Alzheimer's disease (AD) are associated with progressive brain disorganization. Although structural asymmetry is an organizing feature of the cerebral cortex it unknown whether continuous age- AD-related cortical degradation alters asymmetry. Here, in multiple longitudinal adult lifespan cohorts we show that higher-order regions exhibiting pronounced at age ~20 also asymmetry-loss across lifespan. Hence, accelerated thinning (previously) thicker homotopic hemisphere a aging. This...
Major depression (MDD) is characterized by altered emotion processing and deficits in cognitive control. In interference tasks, patients with MDD have shown excessive amygdala activity under-recruitment of dorsolateral prefrontal cortex (DLPFC). The purpose this study was to examine the effects antidepressant treatment on anomalous neural cognitive-control emotion-processing circuitry.Functional magnetic resonance imaging conducted depressed (n=23) (both before after treatment) compared...
<h3>Objective</h3> To assess whether global or regional changes in amyloid burden over 4 years predict early declines episodic memory initially amyloid-negative adults. <h3>Methods</h3> One hundred twenty-six amyloid-negative, cognitively normal participants (age 30–89 years) were included from the Dallas Lifespan Brain Study who completed florbetapir PET and a cognitive battery at baseline 4-year follow-up. Standardized uptake value ratio (SUVR) change was computed across 8 bilateral...
The factors regulating cerebral blood flow (CBF) changes in physiological activation remain the subject of great interest and debate. Recent experimental studies suggest that an increase cytosolic NADH mediates increased working brain. Lactate injection should elevate levels by increasing lactate/pyruvate ratio, which is near equilibrium with NADH/NAD + ratio. We studied CBF responses to bolus lactate at rest visual stimulation using positron-emission tomography seven healthy volunteers....
Background Cerebrovascular reserve, the potential capacity of brain tissue to receive more blood flow when needed, is a desirable marker in evaluating ischemic risk. However, current measurement methods require acetazolamide injection or hypercapnia challenge, prompting clinical need for resting-state (RS) oxygen level–dependent (BOLD) functional MRI data measure cerebrovascular reactivity (CVR). Purpose To optimize and evaluate an RS CVR technique demonstrate its relationship neurosurgical...
A screening questionnaire with high sensitivity for detection of Parkinson's disease would make it easier to identify undiagnosed, yet affected, family members genetic research. We assessed the validity a developed by Duarte et al. [1995: Mov Disord 10:643-649] reported specificity and (PD). applied 78 asymptomatic families that had at least two people diagnosed PD. These were participating in linkage study disease. Examination these revealed 53 normal (normal controls) 25 classified...
It has been known for more than a century that increases in neuronal activity the brain are reliably accompanied by changes local blood flow. More recently it appreciated these flow glycolysis much greater oxidative phosphorylation. proposed us and others this activity-induced increase mediates mechanisms linked through near-equilibrium relationship between cytosolic NADH/NAD + lactate/pyruvate ratios. Here we show awake human subjects transiently raising pyruvate concentration during...
A mutation within the alpha-synuclein gene on human chromosome 4 has been reported to segregate with PD in an Italian family. We screened a sample of familial cases for gene. None carried gene, and no association was detected between alleles dinucleotide repeat marker conclude that variation does not play significant role risk our sample.
Much neuroimaging research has explored the neural mechanisms underlying successful cognitive aging. Two different patterns of functional activation, maintenance youth-like activity and compensatory novel recruitment, have been proposed to represent brain features individual differences in In this study, we investigated individuals across adult lifespan who appeared resist age-related decline, comparison those with typical declines, over course four years. We first implemented latent mixture...
ABSTRACT INTRODUCTION Studies suggest excellent performance of plasma p-tau217 for detecting amyloid pathology, though studies in more diverse populations are needed to validate previously determined cutpoints. METHODS Plasma utility pathology (Aβ) via PET ( n =598) and/or cerebrospinal fluid (CSF; =154) was assessed a heterogeneous, community-based cohort the Wake Forest Alzheimer’s Disease Research Center (WFADRC). Participants were 21% Black; 313 cognitive unimpaired (CU), 214 mild...
Introduction: Stark disparities exist in the prevalence of Alzheimer’s disease (AD) and related dementias (ADRD) by social determinants health (SDoH). Limited research is available on associations SDoH with AD/ADRD biomarkers. This study aims to assess impact measures ADRD-associated neuroimaging plasma Hypothesis: area deprivation index (ADI), vulnerability (SVI), environmental justice (EJI) will be positively associated poorer biomarkers, cardiometabolic partially account for this...
Abstract The bradykinesia associated with Parkinson's disease (PD) can be improved by both levodopa and the use of external cues. We examined combined effect cueing on voluntary reaching movements individuals PD. Nine subjects PD nine matched controls were studied to a ball target. Subjects after being off overnight again their morning dose. Kinematic data collected as all made accurate fast reaches under two different cue conditions: noncued (self‐initiated) cued (triggered light). reached...
We evaluated whether self-reports of worse cognition in older adults with normal cognitive function reflected actual memory decline, amyloid pathology, and subtle vulnerabilities hippocampal function. measured subjective decline (SCD) 156 participants from the Dallas Lifespan Brain Study. Functional activation during encoding, fMRI, longitudinal change that was four years preceding SCD measures were used to predict magnitude SCD. A subsample (N=105) also underwent 18F-Florbetapir PET imaging...
Background: The preclinical Alzheimer’s cognitive composite (PACC) was developed for in-person administration to capture subtle decline. At the outset of COVID-19 pandemic, testing increasingly performed remotely by telephone or video administration. It is desirable have a harmonized measurement derived from both and remote assessments identifying changes examine its relationship with common neuroimaging biomarkers. Objective: We defined telehealth compatible PACC (tPACC) examined biomarkers...
PD is largely a sporadic condition of unknown etiology, but specific inherited mutations are cause PD.To describe large, multi-incident Amish pedigree with PD.Case ascertainment, calculation population prevalence, and kinship coefficients (a measure relatedness between two individuals) for affecteds subjects in large kindred were conducted. Sequencing genes known sufficient to marker-by-marker haplotype analysis chromosomal regions flanking previously described performed.The authors have...
Abstract Normal aging and Alzheimer’s Disease (AD) are accompanied by large-scale alterations in brain organization that undermine function. Although hemispheric asymmetry is a global organizing feature of cortex thought to promote efficiency, current descriptions cortical thinning AD have largely overlooked asymmetry. Consequently, the foundational question whether where cerebral hemispheres change at different rates remains open. First, applying vertex-wise data-driven clustering...
Multiple neuroimaging and clinical biomarkers have been identified to predict cognitive decline progression mild impairment (MCI) or dementia. However, early associated with transition reversion from (cognitive migration) require further understanding. We investigated the impacts of baseline on migration in a community-dwelling older cohort. studied 391 participants Wake Forest Alzheimer's Disease Research Center Clinical Core cohort who underwent neuropsychological assessment magnetic...