A5038817148- Cerebral Palsy and Movement Disorders
- Balance, Gait, and Falls Prevention
- Parkinson's Disease Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Muscle activation and electromyography studies
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Prosthetics and Rehabilitation Robotics
- Muscle Physiology and Disorders
- Musculoskeletal pain and rehabilitation
- Congenital heart defects research
- Diabetic Foot Ulcer Assessment and Management
- Dementia and Cognitive Impairment Research
- Cardiomyopathy and Myosin Studies
- Cellular transport and secretion
- Children's Physical and Motor Development
- Injury Epidemiology and Prevention
- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Effects of Vibration on Health
- Motor Control and Adaptation
- Assistive Technology in Communication and Mobility
- Lysosomal Storage Disorders Research
- Frailty in Older Adults
- Antioxidants, Aging, Portulaca oleracea
University of Washington
2014-2023
Seattle University
2015-2019
The Queen's Medical Research Institute
2017
University of Edinburgh
2017
Imaging Center
2017
Alzheimer's Association
2017
Foundation for Physical Medicine and Rehabilitation
2017
Medical College of Wisconsin
2015
University of Florida
2015
Boston Children's Hospital
2011
Older adults with amnestic mild cognitive impairment (aMCI) are at higher risk for developing Alzheimer disease. Physical performance decline on gait and mobility tasks in conjunction executive dysfunction has implications accelerated functional decline, disability, institutionalization sedentary older aMCI.The purpose of this study was to examine whether 2 tests commonly used by physical therapists (usual speed Timed "Up & Go" Test [TUG]) associated neuropsychological function (Trail Making...
X-linked myotubular myopathy (XLMTM) results from MTM1 gene mutations and myotubularin deficiency. Most XLMTM patients develop severe muscle weakness leading to respiratory failure death, typically within 2 years of age. Our objective was evaluate the efficacy safety systemic therapy in p.N155K canine model by performing a dose escalation study. A recombinant adeno-associated virus serotype 8 (rAAV8) vector expressing (cMTM1) under muscle-specific desmin promoter (rAAV8-cMTM1) administered...
The prevalence of functional mobility limitations and falls is higher in people with dementia compared cognitively healthy older adults, both are associated gait motor impairments. aims this study were to examine concurrent validity physical performance assessments spatiotemporal measures adults advanced prospectively their relationship over a 4-month period.Thirty-one living dementia-specific assisted residences participated. Correlations examined between modified Berg Balance Scale...
Gait impairments are prevalent among people with Parkinson's disease (PD). Instructions to focus on walking can improve in PD, but the use of such a cognitive strategy may be limited under dual-task conditions, when is performed simultaneously concurrent or motor tasks. This study examined how performance and task was affected by instructions PD compared healthy young older individuals. Dual-task characterized two sets as follows: (1) (2) task. People adults walked faster instructed walking....
X-linked myotubular myopathy (XLMTM), a devastating pediatric disease caused by the absence of protein myotubularin, results from mutations in MTM1 gene. While there is no cure for XLMTM, we previously reported effects gene therapy using adeno-associated virus (AAV) vector on muscle weakness and pathology MTM1-mutant dogs. Here, followed 2 AAV-infused dogs over 4 years.We evaluated gait, strength, respiration, neurological function, pathology, AAV copy number (VCN), transgene expression.Four...
Achieving mobility with a prosthesis is common post-amputation rehabilitation goal and primary outcome in prosthetic research studies. Patient-reported measures (PROMs) available to measure have practical psychometric limitations that inhibit their use clinical care research.
Abstract The purpose of this study was to determine the effects unilateral versus bilateral subthalamic nucleus (STN) stimulation on quantitative measures walking and reaching in Parkinson's disease (PD). We used kinematic Unified Disease Rating Scale (UPDRS) motor subscale (subscale III) evaluate movement 6 people with PD who had STN stimulators implanted for at least months withheld their anti‐parkinson medication 8 hours. Subjects were studied both off, one on, on. Kinematic data...
Background. In older adults, changes in speed and stability during walking are associated with impaired balance increased fall risk. Narrow-base requires frontal plane can be used to assess postural control while walking. Performance of a concurrent cognitive task (dual task) may further increase the complexity walking, potentially allowing identification individuals instability that is not detected under single-task conditions. The purpose this study was examine age-associated effects on narrow-base
Many people with lower limb loss report the need to concentrate on walking. This may indicate increased reliance cognitive resources when walking compared individuals without loss.This study quantified changes in associated addition of a concurrent task persons transfemoral amputation using microprocessor knees age- and sex-matched controls.Observational, cross-sectional study.Quantitative motion analysis was used assess under both single-task (walking alone) dual-task while performing task)...
Limited functional mobility in older adults has been associated with declines tests of motor, psychomotor, and executive function. Animal studies have demonstrated reversals indices motor psychomotor function via supplementation polyphenolic-rich foods such as blueberries. The purpose this study was to examine whether 6 weeks daily consumption 2 cups frozen blueberries affects adults. Pre- post-intervention assessments grip strength, simple reaction time, adaptive gait, were completed for...
Background and Purpose: Individuals with Parkinson disease (PD) have motor nonmotor impairments that interfere exercise participation. The purpose of this study was to examine the feasibility physical performance outcomes a community-based indoor tandem cycling program designed facilitate higher cadence, consistency, intensity training. Methods: Forty-one participants mild moderate PD were enrolled. A high-cadence protocol using mechanically augmented (or forced) on bicycle adapted for our...
Decline in dual-task walking performance is associated with increased risk of falls among older adults. The objective this study to determine whether 18 hr participation EnhanceFitness (EF), an evidence-based group exercise program, improves community-dwelling Twenty-eight healthy, adults were evaluated before participating EF and after participation. Gait speed was under single task dual tasks using the TUG (Timed Up Go) 1-min walk tests. Dual-task costs (DTC), relative cost compared...
We have previously demonstrated that neutrophil recruitment to the heart following myocardial infarction (MI) is enhanced in mice lacking 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates active glucocorticoid within cells from intrinsically inert metabolites. The present study aimed identify mechanism of regulation. In a mouse model MI, mobilization blood and were higher 11β-HSD1-deficient ( Hsd11b1 − / ) relative wild-type (WT) mice, despite similar initial injury circulating...