A5036528352- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- Neurological diseases and metabolism
- Transcranial Magnetic Stimulation Studies
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Nuclear Receptors and Signaling
- Mitochondrial Function and Pathology
- Cerebral Palsy and Movement Disorders
- Radiopharmaceutical Chemistry and Applications
- Pharmacological Receptor Mechanisms and Effects
- Neurological and metabolic disorders
- Sphingolipid Metabolism and Signaling
- RNA regulation and disease
- Cholinesterase and Neurodegenerative Diseases
- Dementia and Cognitive Impairment Research
- Nicotinic Acetylcholine Receptors Study
Washington University in St. Louis
2016-2025
American Physical Therapy Association
2007-2023
Hope Center for Neurological Disorders
1992-2023
Mallinckrodt (United States)
2010-2022
Mayo Clinic
2021
Mayo Clinic in Arizona
2021
Brigham and Women's Hospital
2021
The Neurological Institute
2020
Louis Stokes Cleveland VA Medical Center
2020
University of Rochester
2002-2020
Extant methods for anatomical localization within a physiological image are inadequate precise regional correlations between anatomy and physiology. We have developed method determining the location of any region interest positron emission tomographic (PET) by transformation coordinates into stereotactic atlas human brain. The specific assumptions this approach were identified validated groups normal subjects means measurements made from lateral skull radiographs nuclear magnetic resonance...
Mutations in the glucocerebrosidase gene (GBA), which cause Gaucher disease, are also potent risk factors for Parkinson's disease. We examined whether a genetic burden of variants other lysosomal storage disorder genes is more broadly associated with disease susceptibility. The sequence kernel association test was used to interrogate variant among 54 genes, leveraging whole exome sequencing data from 1156 cases and 1679 control subjects. discovered significant rare, likely damaging risk....
Classical accounts of the pathophysiology Parkinson's disease have emphasized degeneration dopaminergic nigrostriatal neurons with consequent dysfunction cortico–striatal–thalamic loops. In contrast, post-mortem studies indicate that pathological changes in (Lewy neurites and Lewy bodies) first appear primarily lower brainstem subsequent progression to more rostral parts neuraxis. The histological perspectives are not incompatible, but they do emphasize different anatomical structures. To...
<h3>Importance</h3> Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine neurons, and was safe well tolerated early-phase human studies. A previous phase II study suggested possible clinical benefit. <h3>Objective</h3> To examine whether CoQ10 could slow progression early PD. <h3>Design, Setting, Participants</h3> III randomized, placebo-controlled, double-blind trial at 67 North...
<h3>Objective:</h3> To investigate the utilization of neurologist providers in treatment patients with Parkinson disease (PD) United States and determine whether is associated improved clinical outcomes. <h3>Methods:</h3> This was a retrospective observational cohort study Medicare beneficiaries PD year 2002. Multilevel logistic regression used to which patient characteristics predicted care between 2002 2005 compare age, race, sex, comorbidity-adjusted annual risk skilled nursing facility...
Interview with Dr. Gil Rabinovici on the FDA's controversial approval of a new treatment for Alzheimer's disease. (16:39)Download Given scientific, regulatory, and clinical implications accelerated FDA aducanumab disease, it's essential to consider beta-amyloid's suitability as surrogate end point. Doing so casts doubt wisdom decision.
Abstract The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation alpha-synuclein (Asyn) fibrils in bodies neurites. Here we develop validate a method to amplify Asyn extracted from LBD postmortem tissue samples use solid state nuclear magnetic resonance (SSNMR) studies determine atomic resolution structure. Amplified comprise mixture single protofilament two with very low twist. fold highly similar determined by recent cryo-electron microscopy study...
We investigated swallowing abnormalities in patients with Parkinson's disease, the relationship between these and general parkinsonian signs, as well response to therapy. Twenty 13 controls were evaluated clinical rating scales modified barium swallows before after oral levodopa (in combination carbidopa). Fifteen patients, but only 1 control, had abnormal (chi 2 = 11.722, df 1, p less than 0.001). Abnormalities included disturbances of pharyngeal phases swallowing. Patients without...
Positron emission tomography was used to study eight patients with panic disorder who were vulnerable lactate-induced panic, not and 25 normal control subjects. Patients had several abnormalities in the resting, nonpanic state: an abnormal hemispheric asymmetry of parahippocampal blood flow, volume, oxygen metabolism; abnormally high whole brain susceptibility episodic hyperventilation. A hypothetical model for neurobiology disorder, involving region its afferent efferent connections, is proposed.
<i>Objective:</i> To determine whether welding-related parkinsonism differs from idiopathic PD. <i>Background:</i> Welding is considered a cause of parkinsonism, but little information available about the clinical features exhibited by patients or this distinct disorder. <i>Methods:</i> The authors performed case-control study that compared 15 career welders, who were ascertained through an academic movement disorders center and to two control groups with One group was sequentially compare...
<b>Objective: </b> To define key issues in the diagnosis of Parkinson disease (PD), to features influencing progression, and make evidence-based recommendations. Two clinical questions were identified: 1) Which diagnostic modalities distinguish PD from other parkinsonian syndromes? 2) predict rate progression? <b>Methods: Systematic review literature was completed. Articles classified according a four-tiered level evidence scheme. Recommendations based on evidence. <b>Results Conclusions: 1....
Objective: To define key issues in the management of Parkinson disease (PD) relating to neuroprotective strategies and alternative treatments, make evidence-based treatment recommendations.Methods: Two clinical questions were identified.1) In a patient diagnosed with PD, are there any therapies that can slow progression?2) Are nonstandard pharmacologic or nonpharmacologic have been shown improve motor function PD? Articles classified according four-tiered level evidence...
van Mier, H., L. W. Tempel, J. S. Perlmutter, M. E. Raichle, and Petersen. Changes in brain activity during motor learning measured with PET: effects of hand performance practice. Neurophysiol. 80: 2177–2199, 1998. The aim this study is to assess continuous design tracing tasks. Three issues were addressed: identification areas involved performing maze square tasks, investigation differences similarities these related dominant nondominant performance, most importantly, examination the...
In this study we have investigated the pathophysiology of two idiopathic focal dystonias: hand cramp with excessive cocontractions agonist and antagonist or forearm muscles during specific tasks, such as writing, facial dystonia manifested by involuntary eyelid spasms (blepharospasm) lower jaw (oromandibular dystonia). We used positron emission tomography (PET) to measure in vivo binding dopaminergic radioligand [ 18 F]spiperone putamen 21 patients these dystonias compared findings those...
<b><i>Objective:</i></b> To assess whether subthalamic nuclei (STN) stimulation's primary mechanism of action is to drive or inhibit output neurons. <b><i>Methods:</i></b> Cerebral blood flow responses STN stimulation were measured using PET in 13 patients with Parkinson disease. Patients scanned stimulators off and on (six scans each condition). Clinical ratings, EMG, videotaping movements obtained at scan. Scans observable tremor movement eliminated from analysis. Brain regions where...
To test the hypothesis that subthalamic nucleus (STN) stimulation in Parkinson disease (PD) patients affects working memory and response inhibition performance, particularly under conditions of high demand on cognitive control.To this hypothesis, spatial (spatial delayed [SDR]) (Go-No-Go [GNG]) tasks requiring varying levels control were administered to with PD previously implanted bilateral STN stimulators (n = 24). Patients did not take medications overnight. Data collected while off,...
To determine the relative contributions of individual pathologic protein deposits associated with dementia in patients Parkinson disease (PD).