A5067037288- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Ion Channels and Receptors
- Pharmacological Receptor Mechanisms and Effects
- Pain Management and Opioid Use
- Peroxisome Proliferator-Activated Receptors
- Inflammatory mediators and NSAID effects
- Advanced Drug Delivery Systems
- Anesthesia and Pain Management
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- Diet and metabolism studies
- Nicotinic Acetylcholine Receptors Study
- Adenosine and Purinergic Signaling
- Sinusitis and nasal conditions
- Musculoskeletal pain and rehabilitation
- Antimicrobial Peptides and Activities
- Adipose Tissue and Metabolism
- Histone Deacetylase Inhibitors Research
- Pediatric Pain Management Techniques
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Biochemical effects in animals
The University of Queensland
2014-2023
Queensland University of Technology
2021
Johns Hopkins University
1997-2001
Behavioral Pharma (United States)
2001
Johns Hopkins Medicine
2001
Michigan State University
1998
Localized inflammation of a rat's hindpaw elicits an accumulation beta-endorphin-(END) containing immune cells. We investigated the production, release, and antinociceptive effects lymphocyte-derived END in relation to cell trafficking. In normal animals, proopiomelanocortin mRNA were less abundant circulating lymphocytes than those residing lymph nodes (LN), suggesting that finite population produces homes LN. Inflammation increased cells from noninflamed inflamed However, content was only...
Cold allodynia, pain in response to cooling, occurs during or within hours of oxaliplatin infusion and is thought arise from a direct effect on peripheral sensory neurons. To characterize the pathophysiological mechanisms underlying acute oxaliplatin-induced cold we established new intraplantar mouse model that rapidly developed long-lasting allodynia mediated entirely through tetrodotoxin-sensitive Nav pathways. Using selective inhibitors knockout animals, found Nav1.6 was key isoform...
N-type calcium channels modulate the release of key pro-nociceptive neurotransmitters such as glutamate and substance P (SP) in central nervous system. Considerable research interest has focused on therapeutic potential peptidic omega-conopeptides, GVIA MVIIA novel analgesic agents, due to their potent inhibition channels. Recently, channel blocker, AM336, was isolated from venom cone snail, Conus catus. Thus, aims this study were (i) document antinociceptive effects AM336 (also known CVID)...
We have previously shown that β-endorphin (END) is contained and released from memory-type T-cells within inflamed tissue it capable to control pain (J Clin Invest 100(1) (1997) 142). Methionine-enkephalin (MET) Dynorphin-A (DYN) are endogenous opioids with preference for δ- κ-opioid receptors, respectively. Both MET DYN produced immune cells. The goal of this study was determine the release characteristics in a rat model localized hindpaw inflammation examine antinociceptive role Freund's...
Background The vanilloid receptor 1 (TRPV1) is critical in the development of inflammatory hyperalgesia. Several receptors including G-protein coupled prostaglandin have been reported to functionally interact with TRPV1 through a cAMP-dependent protein kinase A (PKA) pathway potentiate TRPV1-mediated capsaicin responses. Such regulation may significance pain. However, few functional interactions that inhibit PKA-mediated potentiation responses described. Results In present studies we...
In addition to their well-defined roles in replenishing depleted endoplasmic reticulum (ER) Ca2+ reserves, molecular components of the store-operated entry pathway regulate breast cancer metastasis. A process implicated metastasis that describes conversion a more invasive phenotype is epithelial-mesenchymal transition (EMT). this study we show EGF-induced EMT MDA-MB-468 cells associated with reduction agonist-stimulated and influx, prior induction have high level non-stimulated influx. The...
Conventional oral drug formulations for colonic diseases require the administration of high doses to achieve effective concentrations at target site. However, this exposes patients serious systemic toxicity in order efficacy. To overcome problem, an delivery system was developed by loading a large amount (ca. 34% w/w) prednisolone into 3-aminopropyl-functionalized mesoporous silica nanoparticles (MCM-NH2) and targeting release colon coating nanoparticle with succinylated ε-polylysine (SPL)....
This randomised, double-blind, placebo-controlled trial assessed the efficacy and tolerability of pregabalin to alleviate neuropathic component moderate severe burn pain. Patients aged 18 65 years admitted a burns unit with 5% or greater total body surface area injury were screened participate in trial. Using Neuropathic Pain Scale (NPS), patients scoring 4 higher on 'hot' pain 'sharp' invited participate. Consenting randomly assigned receive placebo for 28 days individual dose titration...
Abstract Background Epithelial-mesenchymal transition (EMT) is a process implicated in cancer metastasis that involves the conversion of epithelial cells to more mesenchymal and invasive cell phenotype. In breast EMT associated with altered store-operated calcium influx changes signalling mediated by activation surface purinergic receptors. this study, we investigated whether MDA-MB-468 induced undergo exhibit mRNA levels channels, pumps exchangers located on intracellular storing...
Low water solubility and thus low bioavailability limit the clinical application of fenbendazole (FBZ) as a potential anticancer drug. Solubilizing agents, such Mobil Composition Matter Number 41 (MCM) drug carrier, can improve drugs. In this study, PEGylated MCM (PEG-MCM) nanoparticles (NPs) were synthesized loaded with FBZ (PEG-MCM-FBZ) to its and, result, cytotoxicity effect against human prostate cancer PC-3 cells. The loading efficiency onto PEG-MCM NPs was 17.2%. size zeta PEG-MCM-FBZ...
A wastewater-based epidemiology (WBE) method is presented to estimate analgesic consumption and assess the burden of treated pain in Australian communities. Wastewater influent samples from 60 communities, representing ∼52% Australia's population, were analyzed quantify concentration analgesics used treat converted estimates amount drug consumed per day 1000 inhabitants using pharmacokinetics WBE data. Consumption was standardized defined daily dose people. The population treatment...