A5061431409- Ion Channels and Receptors
- Ion channel regulation and function
- Heat shock proteins research
- Bioactive Compounds and Antitumor Agents
- Ion Transport and Channel Regulation
- S100 Proteins and Annexins
- Glycosylation and Glycoproteins Research
- Magnesium in Health and Disease
- Coenzyme Q10 studies and effects
- Polysaccharides and Plant Cell Walls
- Nicotinic Acetylcholine Receptors Study
- Monoclonal and Polyclonal Antibodies Research
- Skin and Cellular Biology Research
- Wnt/β-catenin signaling in development and cancer
- HER2/EGFR in Cancer Research
- Silk-based biomaterials and applications
- Plant Micronutrient Interactions and Effects
- Galectins and Cancer Biology
- bioluminescence and chemiluminescence research
- Trace Elements in Health
The University of Queensland
2014-2019
Hypoxia is a feature of the tumour microenvironment that promotes invasiveness, resistance to chemotherapeutics and cell survival. Our studies identify transient receptor potential canonical-1 (TRPC1) ion channel as key component responses hypoxia in breast cancer cells. This regulation includes control specific epithelial mesenchymal transition (EMT) events hypoxia-mediated activation signalling pathways such EGFR, STAT3 autophagy marker LC3B, through hypoxia-inducible factor-1α...
The remodeling of specific calcium-permeable ion channels is a feature some breast cancer subtypes. ORAI1 protein that forms channel responsible for store-operated calcium entry (SOCE) in variety cell types. ORAI3, related isoform, not regulator SOCE most However, ORAI3 does control many estrogen receptor-positive lines, where it also controls proliferation. well-characterized the proliferation and migration basal cells; however, role these types cells remains unclear. Here, we sought to...
Understanding the cause of therapeutic resistance and identifying new biomarkers in breast cancer to predict responses will help optimise patient care. Calcium (Ca(2+))-signalling is important a variety processes associated with tumour progression, including cell migration proliferation. Ca(2+)-signalling also linked acquisition multidrug resistance. This study aimed assess expression level proteins involved an vitro model trastuzumab-resistance ability identified targets reverse and/or act...