A5025539645- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Marine Toxins and Detection Methods
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Chemical Synthesis and Analysis
- Venomous Animal Envenomation and Studies
- Neuropeptides and Animal Physiology
- Pain Mechanisms and Treatments
- Forensic Toxicology and Drug Analysis
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Antimicrobial Peptides and Activities
- Biochemical and Structural Characterization
- Neurobiology and Insect Physiology Research
- Insect and Pesticide Research
- Cardiac electrophysiology and arrhythmias
- Biofuel production and bioconversion
- Cholinesterase and Neurodegenerative Diseases
- Bacterial Genetics and Biotechnology
- Ion Channels and Receptors
- Click Chemistry and Applications
- Enzyme Production and Characterization
- Healthcare and Venom Research
The University of Queensland
2016-2025
AstraZeneca (Brazil)
2023
Cwm Taf University Health Board
2023
Our Lady of the Lake Regional Medical Center
2023
AstraZeneca (Sweden)
2015-2022
Harvard University
2022
Cardiff University
2021
University of California, Davis
2007-2021
Madrid Institute for Advanced Studies
2020
QIMR Berghofer Medical Research Institute
2020
An examination of the metabolic fate R and S isomers warfarin revealed that two were metabolized by different routes. was oxidized to 6-hydroxywarfarin reduced (R,S) alcohol. In contrast, 7-hydroxywarfarin (S,S) also 6-hydroxywarfarin. These observations suggested interactions between other drugs might be manifest stereo-specifically, i.e., have a effect on warfarin, so series experiments conducted with each isomer before after phenylbutazone. The plasma clearance slowed from 3.1 1.1% per h...
Animal venoms have evolved over millions of years for prey capture and defense from predators rivals. Snake venoms, in particular, a wide diversity peptides proteins that induce harmful inflammatory neurotoxic effects including severe pain paralysis, hemotoxic effects, such as hemorrhage coagulopathy, cytotoxic/myotoxic inflammation necrosis. If untreated, many envenomings result death or morbidity humans and, despite advances management, snakebite remains major public health problem,...
1. The role of alpha2-adrenoceptor (AR) subtypes in the modulation acute nociception, motor behaviour and body temperature, has been investigated by determining activity alpha2AR selective agonist dexmedetomidine (Dex) mice devoid individual through either a point (alpha2A) or null (alpha2B/alpha2C) mutation ('knock-out'). 2. In rodent model thermal mouse tail immersion test, Dex, wild type (WT) control animals, produced dose-dependent increase threshold for withdrawal from 52 degrees C...
Abstract Neuroblastoma cells in culture were used to detect sodium channel-specific marine toxins based on an end-point determination of mitochondrial dehydrogenase activity. The assay responds a dose-dependent manner ciguatoxins, brevetoxins, and saxitoxins, delineates the toxic activity as either channel enhancing or blocking. rapidly activating toxins, allowing dose dependent detection 4 6 h. Brevetoxins can be detected at 250 pg, purified ciguatoxins are low picogram subpicogram levels....
Ciguatera is a type of food poisoning that results from eating certain tropical fish which have become toxic. It common in Australia: 175 outbreaks, involved 527 people, were reported Queensland between 1965 and 1984. seems restricted to areas around the Australian coastline. Most reports narrow-barred Spanish mackerel, Scomberomorus commersoni, most caught southern waters. Up 2100 cases may occurred north 1984, not recorded by writers. The symptoms ciguatera Australia are similar those...
The pathogenesis-related (PR) protein superfamily is widely distributed in the animal, plant, and fungal kingdoms implicated human brain tumor growth plant pathogenesis. precise biological activity of PR proteins, however, has remained elusive. Here we report characterization, cloning structural homology modeling Tex31 from venom duct Conus textile. was isolated to >95% purity by activity-guided fractionation using a para-nitroanilide substrate based on putative cleavage site residues found...
ω-Conotoxins selective for N-type calcium channels are useful in the management of severe pain. In an attempt to expand therapeutic potential this class, four new ω-conotoxins (CVIA–D) have been discovered venom piscivorous cone snail, <i>Conus catus</i>, using assay-guided fractionation and gene cloning. Compared with other ω-conotoxins, CVID has a novel loop 4 sequence highest selectivity over P/Q-type radioligand binding assays. CVIA−D also inhibited contractions electrically stimulated...
Cone snails produce highly complex venom comprising mostly small biologically active peptides known as conotoxins or conopeptides. Early estimates that suggested 50-200 are produced per species have been recently increased at least 10-fold using advanced mass spectrometry. To uncover the mechanism(s) responsible for generating this impressive diversity, we used an integrated approach combining second-generation transcriptome sequencing with high sensitivity proteomics. From gland of Conus...