A5028639958- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrest and Resuscitation
- Tracheal and airway disorders
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Congenital Anomalies and Fetal Surgery
- Pulmonary Hypertension Research and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Cardiac Valve Diseases and Treatments
- Congenital heart defects research
- Ultrasound in Clinical Applications
- Cardiovascular Issues in Pregnancy
- Acute Kidney Injury Research
- Blood Coagulation and Thrombosis Mechanisms
- Neonatal Respiratory Health Research
- Simulation-Based Education in Healthcare
- Neurogenetic and Muscular Disorders Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Pancreatic and Hepatic Oncology Research
- Child and Adolescent Health
Charotar University of Science and Technology
2024
University of North Carolina at Chapel Hill
2019-2023
Children's Hospital of Pittsburgh
2005-2021
University of Pittsburgh
2005-2021
University of Pittsburgh Medical Center
2019-2021
University of North Carolina Health Care
2019-2020
University of North Carolina Hospitals
2019
Neurological Surgery
2019
Government Medical College and Hospital
2016
Lumbini Medical College
2015
Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating the established number cardiomyocytes.
Abstract There are minimal data regarding chronic management of single‐ventricle ventricular assist device (VAD) patients. This study aims to describe our center's multidisciplinary team patients supported long term with the Berlin Heart EXCOR Pediatric VAD. Patient #1 was a 4‐year‐old double‐outlet right ventricle aortic atresia, L‐looped ventricles, and heart block who developed failure 1 year after Fontan. She initially required extracorporeal membrane oxygenation support transitioned...
To identify patient- and disease-related factors related to survival favorable outcomes for children who underwent extracorporeal cardiopulmonary resuscitation after a refractory cardiac arrest.Retrospective observational study with prospective assessment of long-term functional outcome.Fifty-six consecutive undergoing at our institution from 2007 2015. Median age arrest was 3.5 months (interquartile range, 1-53).Tertiary pediatric university hospital referral heart center.Health-related...
To determine the relationship between production of cell-free plasma hemoglobin and acute kidney injury in infants children undergoing cardiopulmonary bypass for cardiac surgery.
Examine the relationship between perioperative renal regional tissue oximetry, urinary biomarkers, and acute kidney injury in infants after congenital cardiac surgery with cardiopulmonary bypass.Prospective, observational.Cardiac operating room ICU.Neonates without history of or anatomic abnormality.None.Renal oximetry was measured intraoperatively for 48 hours postoperatively. Urinary levels neutrophil gelatinase-associated lipocalin inhibitor metalloproteinases 2 together insulin-like...
Children with heart failure unresponsive to medical therapy are left few options for survival. Ventricular assist devices (VADs) life-saving such patients, allowing bridge transplantation or cardiac recovery. Retrospective review of cases from May 2006 October 2010 was undertaken. Fourteen patients underwent implantation VADs refractory failure. Mean age 9 years (range 1-17 years), and weight 41 kg 9.7-71 kg). Indications support: end-stage cardiomyopathy (n = 8), myocarditis 3),...
Extracorporeal membrane oxygenation (ECMO) circuit volume, patient size, and blood flow may influence coagulation hemolysis complications. We performed a single-center retrospective analysis of ECMO patients over 6.5 year period. In 299 runs, 13% required coagulation-associated changes. Respiratory was associated with changes [odds ratio (O/R) 2.8, p < 0.05] developed severe (plasma-free hemoglobin [pfHb] > 100 mg/dl) (O/R 2.3, 0.05). Severe component were hospital mortality 2.3 2.5,...
Thrombocytopenia-associated multi-organ failure (TAMOF) in children is a well-described factor for increased hospital mortality. Low cardiac output syndrome (LCOS) and the effects of cardiopulmonary bypass may manifest with several adverse physiologic immunologic effects, varying degrees thrombocytopenia dysfunction, sometimes very similar to TAMOF. LCOS common occurrence critical heart disease, presenting as much 23.8% infants postoperative congenital surgery. Therapeutic plasma exchange...
Background: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides respiratory and hemodynamic support to pediatric patients in severe cardiac failure. We aim identify risk factors associated with poorer outcomes this population. Methods: A retrospective chart review was conducted of requiring VA-ECMO for indications at our institution from 2004 2015. Data were collected on demographics, indication, markers output, ventricular assist device (VAD) insertion, heart...
Our high-fidelity simulation model provides a realistic example for health-care professionals to experience cannulation, initiation, and hemodynamic stabilization during extracorporeal membrane oxygenation (ECMO) therapy. This educational brings variety of critical care specialties together, in controlled setting, develop, master, maintain clinical skills. may include perfusionists, ECMO specialists, surgical technicians, registered nurses, physicians, students. The component includes unique...
An intraductal papillary mucinous tumor (IPMT) is a rare cystic lesion of the pancreas, comprising only 1% all pancreatic exocrine neoplasms. The prognosis for these lesions typically favorable as compared with invasive ductal carcinomas. Nevertheless, management IPMTs involves surgical resection due to their malignant potential. When located in head, conventional treatment IPMT pancreatoduodenectomy. Some authors have advocated limited pancreatectomy low-grade thereby decreasing morbidity...
To determine the production of 9-hydroxyoctadecadienoic acid and 13-hydroxyoctadecadienoic during cardiopulmonary bypass in infants children undergoing cardiac surgery, evaluate their relationship with increase cell-free plasma hemoglobin, provide evidence bioactivity through markers inflammation vasoactivity (WBC count, milrinone use, vasoactive-inotropic score), examine association overall clinical burden (ICU/hospital length stay mechanical ventilation duration).
Children with heart failure unresponsive to medical therapy are left few options for survival. Pulsatile paracorporeal ventricular assist devices life-saving such patients, allowing bridge transplantation or cardiac recovery. From March 1997 July 2004, 12 patients underwent implantation of Thoratec biventricular (BVADs) refractory failure. Mean age was 14.9 (range 7–20) and mean BSA 1.7 1.1–1.9). Indications support included end-stage cardiomyopathy (n = 10), myocarditis 1), postcardiotomy...
Introduction:Extracorporeal membrane oxygenation (ECMO) is an invaluable rescue technique for critically ill children with imminent or present cardiopulmonary collapse. However, medical team expertise to optimize results and decrease complications scarce. Telemedicine can be used enhance the delivery of quality interventions. Materials Methods:This a retrospective review pediatric patients assisted ECMO in cardiac intensive care unit (CICU) at Fundación Cardiovascular de Colombia from July...
Transvenous implantation of a cardiac resynchronization therapy defibrillator (CRT‐D) may not be feasible due to anatomic constraints. One the most notable advances in minimal‐access heart surgery has been introduction robotic telemanipulation systems. We present challenging case which CRT‐D system was implanted using approach. Feasibility such an approach expands horizons for delivery therapy.
We present a case of neonate with trisomy 21, ductal-dependent aortic coarctation, and severe respiratory failure secondary to coronavirus disease 2019 (COVID-19) pneumonia. The was managed venoarterial extracorporeal membrane oxygenation (VA ECMO), palliative stenting the vascular plug occlusion large patent ductus arteriosus. patient successfully weaned off (ECMO). is currently awaiting definitive surgical repair in near future.
Medical simulation provides a realistic environment for practitioners to experience planned clinical event in controlled educational setting. We established model composed of synthetic ballistic gelatin that provided an inexpensive high-fidelity our extracorporeal membrane oxygenation (ECMO) team members develop, master, and maintain skills necessary percutaneous cervical or femoral cannulation. The component includes torso is attached either static fluid the perfusion simulator. Either can...