A5090186512- Transplantation: Methods and Outcomes
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Organ Transplantation Techniques and Outcomes
- Mechanical Circulatory Support Devices
- Renal Transplantation Outcomes and Treatments
- Sperm and Testicular Function
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Reproductive Health and Technologies
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
- Reformation and Early Modern Christianity
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive System and Pregnancy
- Diet and metabolism studies
- Pluripotent Stem Cells Research
- Systemic Sclerosis and Related Diseases
- Pulmonary Hypertension Research and Treatments
- Renal and related cancers
- Social and Intergroup Psychology
- Lung Cancer Diagnosis and Treatment
- Polyomavirus and related diseases
- Tissue Engineering and Regenerative Medicine
- Australian History and Society
- Occupational and Professional Licensing Regulation
University of Pittsburgh Medical Center
2019-2025
The Ohio State University Wexner Medical Center
2024
Jiangxi Copper (China)
2024
University of Pittsburgh
2013-2024
Wright-Patterson Air Force Base
2024
University of Virginia
2021
University of San Diego
2020
UPMC Health System
2020
King Edward Memorial Hospital
2014-2018
The University of Western Australia
2014-2018
Is in vitro maturation (IVM) as successful standard fertilization (IVF) for the treatment of patients with polycystic ovaries (PCO) terms fresh, frozen and cumulative pregnancy outcomes? There was no difference clinical rates fresh or embryo transfer (FET) cycles between two groups however, IVM group showed a lower rate cumulatively. significantly fewer live births resulting from both cycle outcomes there birth FETs IVF treatment. is well recognized only option to eliminate completely...
OBJECTIVES: Extracorporeal membrane oxygenation is a life-sustaining therapy for severe respiratory failure. circuits require systemic anticoagulation that creates delicate balance between circuit-related thrombosis and bleeding-related complications. Although unfractionated heparin most widely used anticoagulant, alternative agents such as bivalirudin have been used. We sought to compare extracorporeal circuit outcomes in failure patients receiving either or on venovenous support. DESIGN:...
Importance Identifying patients at high risk of adverse outcomes prior to surgery may allow for interventions associated with improved postoperative outcomes; however, few tools exist automated prediction. Objective To evaluate the accuracy an machine-learning model in identification from using only data electronic health record. Design, Setting, and Participants This prognostic study was conducted among 1 477 561 undergoing 20 community tertiary care hospitals University Pittsburgh Medical...
As brainstem nuclei are interconnected with several cortical structures and regulate autonomic, cognitive, behavioral functions, it might be important to place the within an pathologic core in progression of Alzheimer's disease (AD). Although there have been postmortem studies reporting neuropathological alterations AD, has no in-vivo structural neuroimaging study patients AD. The aim this was investigate differences volume shape between AD elderly normal controls. Fifty (the Clinical...
ObjectiveDonation after circulatory death (DCD) donors offer the ability to expand lung donor pool and ex vivo perfusion (EVLP) further contributes this by allowing for additional evaluation resuscitation of these extended criteria donors. We sought determine outcomes recipients receiving organs from DCD EVLP in a multicenter setting.MethodsThis was an unplanned post hoc analysis multicenter, prospective, nonrandomized trial that took place during 2011 2017 with 3 years follow-up. Patients...
Insulin resistance (IR) confers risk for Type 2 diabetes and is associated with depressed mood. Neurons within the ventral striatum (VS) are sensitive to insulin levels show altered function in context of both IR depression. Hence, VS may represent a critical component neural circuitry linking mood.Ninety adults (aged 30-50 years) free from major psychiatric illnesses participated. Fasting blood was sampled, participants completed set questionnaires (including Beck Depression Inventory-II)....
Although microvascular complications are common in type 1 diabetes mellitus (T1DM), few studies have quantified the severity, risk factors, and implications of cerebral damage these patients. As life expectancy patients with T1DM increases, exposed to age- disease-related factors that may contribute disease.Severity volume white matter hyperintensities (WMH) infarcts were 97 middle-aged childhood-onset (mean age duration: 50 41 years, respectively) 81 non-T1DM adults age: 48 years),...
Does polycystic ovarian syndrome (PCOS) or in vitro maturation (IVM) treatment affect embryo development events and morphokinetic parameters after time-lapse incubation? There was an increase some abnormal phenotypic PCOS-IVM embryos as well early arrest of PCOS-ICSI embryos; however, IVM PCOS status did not alter suitable for transfer vitrification. has been less successful than standard IVF terms clinical pregnancy, implantation live birth rates. is currently no information available about...
Abstract Factors affecting the production of platelet activating factor (PAF) by mouse embryos during culture in vitro were investigated. Detectable levels embryo‐derived PAF produced within 1–4 hr with maximum activity being observed after 6 vitro. The amount detected media 24 two‐cell was equivalent to 12.8 ng PAF/embryo. However, differences apparent increased time culture. Reduced synthesis supported observation that morulae stage collected fresh from reproductive tract displayed more...
Although mouse oocytes and cleavage-stage embryos prefer pyruvate lactate for metabolic fuels, they do take up metabolize glucose. Indeed, presentation of glucose during the cleavage stages is required subsequent blastocyst formation, which normally relies on uptake metabolism large amounts Expression facilitative transporter GLUT1 was examined using immunohistochemistry Western blotting, in polyspermic oocytes, measured compared with that glutamine. observed all embryos, membrane vesicular...
Summary. Supplementation of culture media with PAF failed to increase the proportion 2-cell mouse embryos which developed through expanded blastocyst stage after 72 h in vitro. Culture 1·86 μm-PAF, however, significantly increased number cells blastocysts. vitro 0·186 or μm-PAF ability implant upon transfer pseudopregnant recipients. The specificity this effect was demonstrated by its inhibition specific PAF-receptor antagonist, SRI 63-441. Of implanted, there no difference proportions...
Due to the high prevalence of actinic keratosis (AK) and potential for lesions become cancerous, clinical guidelines recommend that all are treated. The objective this study was evaluate efficacy safety 5-fluorouracil (5-FU) 0.5%/salicylic acid 10% as field-directed treatment AK lesions. This multicenter, double-blind, vehicle-controlled (NCT02289768) randomized adults, with a 25 cm2 area skin on their face, bald scalp, or forehead covering 4–10 clinically confirmed (grade I/II), 2:1 vehicle...
The number of lung transplants from donors after circulatory death has increased over the last decade. This study aimed to describe evolution and outcomes following transplantation donation (DCD) report practices ex vivo perfusion (EVLP) in this donor population.This was a retrospective using prospectively collected national registry. United Network for Organ Sharing (UNOS) database queried identify adult patients who underwent between May 1, 2005, December 31, 2021. Kaplan-Meier analysis...
The effect of early- and mid-follicular LH concentrations on the ovarian response pregnancy outcomes was evaluated in women receiving pituitary down-regulation with a GnRH agonist stimulation recombinant FSH (rFSH) during IVF/ICSI treatment.Blood samples were collected prospectively from 701 cycles (560 patients) assisted reproduction analysed retrospectively. On basis day 7/8, patients divided into two groups: LH<1.2 IU/l (n=179) LH>or=1.2 (n=522). Cycle also compared ratio mid- to...
Summary. The effects of exogenous platelet-activating factor (PAF, 0·0186–18·6 μm) on the production CO2 from [U-14C]glucose and [1-14C]lactate by mouse embryos in vitro were investigated. Two-cell displayed significant dose-dependent responses for both energy substrates. maximal response was observed at 9·3 μm-PAF glucose metabolism 1·86 lactate with increases 62% 18%, respectively, over control treatments. After culture 2-cell stage 72 h presence PAF, resulting blastocysts exhibited a...