A5070432469- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Mechanical Circulatory Support Devices
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Respiratory viral infections research
- Lung Cancer Diagnosis and Treatment
- Polyomavirus and related diseases
- Esophageal Cancer Research and Treatment
- Dysphagia Assessment and Management
- Lung Cancer Treatments and Mutations
- Pneumocystis jirovecii pneumonia detection and treatment
- Eosinophilic Esophagitis
- Medical Imaging and Pathology Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Organ and Tissue Transplantation Research
- Congenital Diaphragmatic Hernia Studies
- Pulmonary Hypertension Research and Treatments
- Inhalation and Respiratory Drug Delivery
- Respiratory Support and Mechanisms
- Metabolism and Genetic Disorders
Columbia University
2016-2025
Columbia University Irving Medical Center
2016-2025
Presbyterian Hospital
2008-2024
NewYork–Presbyterian Hospital
2008-2024
Barnes-Jewish Hospital
2000-2024
Emory University
2024
AdventHealth Orlando
2024
Mayo Clinic Hospital
2024
Duke University
2024
University of Pennsylvania
2024
Functional studies may be useful to predict survival in idiopathic pulmonary fibrosis (IPF). Various cutoffs of 6-min-walk distance (6MWD) have been suggested identify patients at a high risk death.
Human tissue-resident memory T cells persist long term in transplanted lungs and develop from infiltrating recipient cells.
Frailty is associated with morbidity and mortality in abdominal organ transplantation but has not been examined lung transplantation.To examine the construct predictive validity of frailty phenotypes transplant candidates.In a multicenter prospective cohort, we measured Fried Phenotype (FFP) Short Physical Performance Battery (SPPB). We evaluated through comparisons conceptually related factors. In nested case-control study frail nonfrail subjects, serum IL-6, tumor necrosis factor receptor...
Rationale: Remodeling and loss of distal conducting airways, including preterminal terminal bronchioles (pre-TBs/TBs), underlie progressive airflow limitation in chronic obstructive pulmonary disease (COPD). The cellular basis these structural changes remains unknown. Objectives: To identify biological pre-TBs/TBs COPD at single-cell resolution determine their origin. Methods: We established a novel method airway dissection performed transcriptomic profiling 111,412 cells isolated from...
Gastro-esophageal reflux and related pulmonary bile acid aspiration were prospectively investigated as possible contributors to postlung transplant bronchiolitis obliterans syndrome (BOS). We also studied the impact of on surfactant collectin proteins SP-A SP-D phospholipids--all important components innate immunity in lung. Proximal distal esophageal 24-h pH testing broncho-alveolar lavage fluid (BALF) assays performed at 3-month posttransplant 50 patients. BALF was assayed for SP-A,...
Obesity is considered a relative contraindication to lung transplantation, based on studies that have not accounted for key confounders. Little known about the risk of death underweight candidates after transplantation.
Obesity and underweight are contraindications to lung transplantation based on their associations with mortality in studies performed before implementation of the allocation score (LAS)-based organ system United States Objectives: To determine body mass index (BMI) plasma leptin levels survival after transplantation.We used multivariable-adjusted regression models examine between BMI 1-year 9,073 adults who underwent May 2005 June 2011, 599 Lung Transplant Outcomes Group study participants....
Frailty is associated with increased mortality among lung transplant candidates. We sought to determine the association between frailty, as measured by Short Physical Performance Battery (SPPB), and after transplantation. In a multicenter prospective cohort study of adults who underwent transplantation, preoperative frailty was assessed SPPB (n = 318) and, in secondary analysis, Fried Phenotype (FFP; n 299). tested following transplantation propensity score-adjusted Cox models. calculated...
ObjectiveDonation after circulatory death (DCD) donors offer the ability to expand lung donor pool and ex vivo perfusion (EVLP) further contributes this by allowing for additional evaluation resuscitation of these extended criteria donors. We sought determine outcomes recipients receiving organs from DCD EVLP in a multicenter setting.MethodsThis was an unplanned post hoc analysis multicenter, prospective, nonrandomized trial that took place during 2011 2017 with 3 years follow-up. Patients...
Characteristics of and survival estimates for recipients lung retransplantation in the modern era are unknown.To compare retransplant patients with historical patients, to initial transplant era, determine predictors risk death after retransplantation.We performed a retrospective cohort study who underwent between January 2001 May 2006 United States (modern cohort). The characteristics this were compared those first 1990 December 2000 (historical cohort) transplantation cohort).Modern (n =...
Many transplant programs are hesitant to offer lung transplantation patients with systemic sclerosis (SSc) due concerns about extrapulmonary involvement that might affect survival. The aim of this study was determine whether adults SSc have higher 1-year mortality rates after compared those interstitial disease (ILD) or pulmonary arterial hypertension (PAH) not SSc.Using data provided by the United Network for Organ Sharing, we performed a retrospective cohort 229 SSc, 201 PAH, and 3,333 ILD...
There are limited data describing COVID-19 in lung transplant recipients. We performed a single center, retrospective case series study of patients followed by the Columbia Lung Transplant program who tested positive for SARS-CoV-2 between March 19 and May 19, 2020. Thirty-two developed mild (16%), moderate (44%), or severe (41%) COVID-19. The median age was 65 years, time from 5.6 years. Symptoms included cough (66%), dyspnea (50%), fever (47%), gastrointestinal upset (44%). Patients...
Raviv Y, D’Ovidio F, Pierre A, Chaparro C, Freeman M, Keshavjee S, Singer LG. Prevalence of gastroparesis before and after lung transplantation its association with allograft outcomes. Clin Transplant 2012: 26: 133–142. © 2011 John Wiley & Sons A/S. Abstract: The main cause late morbidity mortality is bronchiolitis obliterans syndrome (BOS). This study assesses the prevalence among lung‐transplant recipients BOS. files 139 patients who underwent nuclear gastric emptying studies and/or...
Lungs from older adult organ donors are often unused because of concerns for increased mortality. We examined associations between donor age and transplant outcomes among 8860 lung recipients using Organ Procurement Transplantation Network Lung Transplant Outcomes Group data. used stratified Cox proportional hazard models generalized linear mixed to examine both 1-year graft failure primary dysfunction (PGD). The rate was similar lungs 18–64 years, but severely ill (Lung Allocation Score...