A5073254862- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Renal Transplantation Outcomes and Treatments
- Polyomavirus and related diseases
- Tracheal and airway disorders
- Organ Transplantation Techniques and Outcomes
- Respiratory viral infections research
- Mechanical Circulatory Support Devices
- Lung Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Cell Function and Interaction
- Medical Imaging and Pathology Studies
- Immunodeficiency and Autoimmune Disorders
- Cystic Fibrosis Research Advances
- Viral Infections and Immunology Research
- Lung Cancer Treatments and Mutations
- Systemic Sclerosis and Related Diseases
- Pulmonary Hypertension Research and Treatments
- Mycobacterium research and diagnosis
- Radiomics and Machine Learning in Medical Imaging
- Cytomegalovirus and herpesvirus research
- Frailty in Older Adults
- Antifungal resistance and susceptibility
- Blood groups and transfusion
UCSF Helen Diller Family Comprehensive Cancer Center
2022-2025
University of California, San Francisco
2016-2025
Twitter (United States)
2024
Advanced ENT and Allergy
2013-2021
University Health Network
2021
University of California System
2011-2020
University of California San Francisco Medical Center
2007-2018
University of California, San Diego
1996-1997
Stanford University
1994
Tens of thousands patients with advanced lung diseases may be eligible to considered as potential candidates for transplant around the world each year. The timing referral, evaluation, determination candidacy, and listing continues pose challenges even ethical dilemmas. To address these challenges, International Society Heart Lung Transplantation appointed an international group members review literature, consider recent advances in management diseases, update prior consensus documents on...
2][3][4] In 2011, it is estimated that 156,900 deaths (85,600 in men, 71,300 women) from lung cancer will occur the United States. 4Five-year survival rates for are only approximately 15.6%, partly because most patients have advanced-stage at initial diagnosis (http:// seer.cancer.gov/statfacts/html/lungb.html). 5hese facts, combined with success of screening improving outcomes cervical, colon, and breast cancers,
Frailty is associated with morbidity and mortality in abdominal organ transplantation but has not been examined lung transplantation.To examine the construct predictive validity of frailty phenotypes transplant candidates.In a multicenter prospective cohort, we measured Fried Phenotype (FFP) Short Physical Performance Battery (SPPB). We evaluated through comparisons conceptually related factors. In nested case-control study frail nonfrail subjects, serum IL-6, tumor necrosis factor receptor...
The NCCN Guidelines for Lung Cancer Screening recommend criteria selecting individuals screening and provide recommendations evaluation follow-up of lung nodules found during initial subsequent screening. These Insights focus on recent updates to the Screening.
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Lung Cancer Screening provide recommendations selecting individuals lung cancer screening, and evaluation follow-up of nodules found during are intended to assist with clinical shared decision-making. These Insights focus on the major updates 2015 Screening, which include a revision recommendation from category 2B 2A one high-risk groups eligible screening. For low-dose CT lung, recommended slice width was revised table...
The immune system is designed to robustly respond pathogenic stimuli but be tolerant endogenous ligands not trigger autoimmunity. Here, we studied an damage-associated molecular pattern, mitochondrial DNA (mtDNA), during primary graft dysfunction (PGD) after lung transplantation. We hypothesized that cell-free mtDNA released ischemia–reperfusion triggers neutrophil extracellular trap (NET) formation via TLR9 signaling. found increases in the BAL fluid of experimental PGD (prolonged cold...
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Lung Cancer Screening provide criteria selecting individuals screening and offer recommendations evaluating managing lung nodules detected during initial subsequent annual screening. These Insights focus on recent updates to the Screening.
To determine the prevalence and proximal extent of gastroesophageal reflux (GERD) in patients awaiting lung transplantation.GERD has been postulated to contribute accelerated graft failure who have had transplantations. However, symptoms, esophageal motility abnormalities, among with end-stage disease transplantation are unknown.A total 109 underwent symptomatic assessment, manometry, pH monitoring (using a probe 2 sensors located 5 20 cm above lower sphincter).Reflux symptoms were not...
Background Lung disease is the leading cause of death in systemic sclerosis (SSc). The diagnosis SSc-related lung (SSc-LD) often a contraindication to transplantation (LT) due concerns that extrapulmonary involvement will yield worse outcomes. We sought evaluate posttransplantation outcomes persons with SSc-LD esophageal compared nonconnective tissue disease–related interstitial (nCTD-ILD). Methods From 1998 2012, undergoing LT for were age and gender matched 2:1 fashion controls nCTD-ILD....
Donor-specific antibodies (DSA) to mismatched human leukocyte antigens (HLA) are associated with worse outcomes after lung transplantation. To determine the incidence and characteristics of DSA early transplantation, we conducted a prospective multicenter observational study that used standardized treatment testing protocols. Among 119 transplant recipients, 43 (36%) developed DSA: 6 (14%) only class I HLA, 23 (53%) II 14 (33%) both HLA. The median mean fluorescence intensity (MFI) was 3197....
Acute lung allograft dysfunction (ALAD) is an imprecise syndrome denoting concern for the onset of chronic (CLAD). Mechanistic biomarkers are needed that stratify risk ALAD progression to CLAD. We hypothesized single cell investigation bronchoalveolar lavage (BAL) cells at time would identify immune linked progressive graft dysfunction.
Lung transplantation in mechanically ventilated (MV) patients has been associated with decreased posttransplant survival. Under the Allocation Score (LAS) system, at greatest risk of death on waiting list, particularly those requiring MV, are prioritized for lung allocation. We evaluated whether pretransplant MV is poorer survival LAS era. Using a national registry, we analyzed all adults undergoing United States from 2005 to 2010. Propensity scoring identified nonventilated matched...
Rationale: HIV seropositivity has long been considered a contraindication to lung transplantation, primarily because of the potential risks added immunosuppression. In past decade, however, experience with kidney and liver transplantation in setting infection, achievement satisfactory outcomes, grown considerably. This promising development created need reconsider this transplantation.Objectives: There is presently limited evidence upon which base medical decision-making regarding...
Lung transplantation and related medications are associated with pathobiological changes that can induce frailty, a state of decreased physiological reserve. Causes persistent or emergent frailty after lung transplantation, whether such transplant-related is key outcomes, unknown.Frailty health-related quality life (HRQL) were prospectively measured repeatedly for up to 3 years transplantation. Frailty, quantified by the Short Physical Performance Battery (SPPB), was tested as time-dependent...