A5091516334- Cardiac Valve Diseases and Treatments
- Transplantation: Methods and Outcomes
- Infective Endocarditis Diagnosis and Management
- Drug-Induced Adverse Reactions
- Mechanical Circulatory Support Devices
- Organ Transplantation Techniques and Outcomes
- Aortic Disease and Treatment Approaches
- Cardiac Imaging and Diagnostics
- Renal Transplantation Outcomes and Treatments
- Tracheal and airway disorders
- Cardiovascular Function and Risk Factors
- Urticaria and Related Conditions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Food Allergy and Anaphylaxis Research
- Autoimmune Bullous Skin Diseases
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Contact Dermatitis and Allergies
- Eosinophilic Disorders and Syndromes
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
Cleveland Clinic
2010-2025
Prince of Wales Hospital
2022-2025
UNSW Sydney
2023-2025
South Eastern Sydney Local Health District
2025
Nepean Hospital
2018-2024
The University of Sydney
2016-2024
University of Notre Dame
2023
The University of Notre Dame Australia
2023
The University of Adelaide
2023
American Association for Thoracic Surgery
2023
Penicillin allergy is a significant public health issue for patients, antimicrobial stewardship programs, and services. Validated clinical decision rules are urgently needed to identify low-risk penicillin allergies that potentially do not require skin testing by specialist.To develop validate rule enables point-of-care risk assessment of patient-reported allergies.In this diagnostic study, multicenter prospective antibiotic allergy-tested cohort 622 patients from 2 tertiary care sites in...
In transcatheter aortic valve replacement (TAVR) recipients, the optimal management of concomitant chronic obstructive coronary artery disease (CAD) remains unknown. Some advocate for pre-TAVR percutaneous intervention, while others manage it expectantly. The aim this study was to assess impact varying degrees and extent untreated CAD on TAVR longer-term outcomes.
Allopurinol (ALP) hypersensitivity is a major cause of severe cutaneous adverse reactions and strongly associated with the HLA-B*58:01 allele. However, it can occur in absence this allele identical clinical manifestations. The immune mechanism ALP-induced poorly understood, T cell-reactivity pattern patients or without not known. To understand interactions among drug, HLA, TCR, we generated cell lines that react to ALP its metabolite oxypurinol (OXP) from HLA-B*58:01(+) HLA-B*58:01(-) donors...
Background Allopurinol is a main cause of severe cutaneous adverse reactions (SCAR). How allopurinol induces hypersensitivity remains unknown. Pre-disposing factors are the presence HLA-B*58:01 allele, renal failure and possibly dose taken. Objective Using an in vitro model, we sought to decipher relationship among metabolism, phenotype drug concentrations stimulating drug-specific T cells. Methods Lymphocyte transformation test (LTT) results patients who had developed were analysed. We...
Background: The conventional method of implanting balloon-expandable SAPIEN-3 (S3) valve results in a final 70:30 or 80:20 ratio the aorta:left ventricular outflow tract with published rates permanent pacemaker around 10%. We sought to evaluate whether higher implantation S3 reduces conduction abnormalities including need for pacemaker. Methods: included consecutive patients who underwent transfemoral transcatheter aortic replacement using between April 2015 and December 2018 compared...
Abstract Monokine induced by IFN-γ (MIG; CXC chemokine ligand (CXCL)9) is important in T lymphocyte recruitment organ transplantation. However, it not known whether this chemokine, addition to its chemotactic properties, exerts any effect on effector functions. For vivo studies, we used a previously characterized murine model of chronic rejection. The recipient mice were treated with anti-MIG/CXCL9 Ab; graft-infiltrating cells analyzed for production. vitro exogenous CXCR3 ligands added CD4...
Chemokine-chemokine receptor interaction and the subsequent recruitment of T-lymphocytes to graft are early events in development chronic rejection transplanted hearts or cardiac allograft vasculopathy (CAV). In this study, we sought determine whether blockade chemokine receptors CCR1 CCR5 with Met-RANTES affects CAV a murine model.B6.CH-2(bm12) strain donor were heterotopically into wild-type C57BL/6 mice (myosin heavy chain II mismatch). Recipients treated daily either vehicle starting on...
The clinical use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation (LTx) has greatly increased in recent years. However, practices for ECMO LTx vary widely between centers. To better define the current practice LTx, we surveyed pre-LTx among all adult programs United States. All US centers were (n = 57) January and December 2014. Responses received from 33 57 (58%). Of responding centers, six (18%) performed ≥50 LTxs per year (defined high volume) two (6%) <10...