A5045174120- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Tracheal and airway disorders
- TGF-β signaling in diseases
- Esophageal and GI Pathology
- Epigenetics and DNA Methylation
- Medical Imaging and Pathology Studies
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Neonatal Respiratory Health Research
- Hedgehog Signaling Pathway Studies
- Angiogenesis and VEGF in Cancer
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Cancer-related Molecular Pathways
- Chemical Reactions and Isotopes
- Cell Adhesion Molecules Research
Moores Cancer Center
2017-2025
UC San Diego Health System
2025
University of San Diego
2025
University of California, San Diego
2016-2024
Sanford Consortium for Regenerative Medicine
2024
Duke Medical Center
2009-2023
Seattle Cancer Care Alliance
2022
Cancer Research Center
2022
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2022
Fred Hutch Cancer Center
2022
The pseudostratified epithelium of the mouse trachea and human airways contains a population basal cells expressing Trp-63 ( p63 ) cytokeratins 5 Krt5 Krt14 . Using KRT5-CreER T2 transgenic line for lineage tracing, we show that generate differentiated during postnatal growth in adult both steady state epithelial repair. We have fractionated by FACS identified 627 genes preferentially expressed subpopulation vs. non-BCs. Analysis reveals potential mechanisms regulating allows comparison with...
Advantages of thoracoscopic lobectomy for early stage non-small cell lung cancer (NSCLC), as compared with by conventional thoracotomy, include less postoperative pain and shorter length hospitalization. The outcomes after in patients more complex pulmonary conditions are analyzed to determine safety, efficacy, versatility.A prospective database 500 consecutive who underwent between June 1999 January 2006 was queried. Demographic, histopathologic, perioperative, outcome variables were...
Identifying the cells of origin lung cancer may lead to new therapeutic strategies. Previous work has focused upon putative bronchoalveolar stem cell at bronchioalveolar duct junction as a when codon 12 K-Ras mutant is induced via adenoviral Cre inhalation. In present study, we use two “knock-in” Cre-estrogen receptor alleles inducibly express K-RasG12D in CC10 + epithelial and Sftpc type II alveolar adult mouse lung. Analysis these mice identifies cells, Clara terminal bronchioles, for...
In Brief Objective: Using a national database, we asked whether video-assisted thoracoscopic surgery (VATS) lobectomy is beneficial in high-risk pulmonary patients. Background: Single-institution series demonstrated benefit of VATS over via thoracotomy poor function patients [FEV1 (forced expiratory volume 1 second) or DLCO (diffusion capacity the lung to carbon monoxide) <60% predicted]. Methods: The STS General Thoracic Database was queried for having undergone by either between 2000 and...
Transcriptional profiling of human cutaneous and oral wound healing reveals pathways involved in rapid resolution.
Purpose Data on optimal adjuvant therapy after complete resection of small-cell lung cancer (SCLC) are limited, and in particular, there have been no studies evaluating the role chemotherapy, with or without prophylactic cranial irradiation, relative to for stage T1-2N0M0 SCLC. This National Cancer Base analysis was performed determine potential benefits chemotherapy irradiation patients who undergo early-stage cancer. Patients Methods Overall survival pathologic SCLC underwent from 2003...
The NCCN Guidelines for Lung Cancer Screening recommend criteria selecting individuals screening and provide recommendations evaluation follow-up of lung nodules found during initial subsequent screening. These Insights focus on recent updates to the Screening.
Background SOX2 (Sry-box 2) is required to maintain a variety of stem cells, overexpressed in some solid tumors, and expressed epithelial cells the lung. Methodology/Principal Findings We show that human squamous cell lung tumors adenocarcinomas. have generated mouse models which Sox2 upregulated during development adult. In both cases, overexpression leads extensive hyperplasia. terminal bronchioles, trachea-like pseudostratified epithelium develops with p63-positive underlying columnar...
Several recent studies have demonstrated the low yield of anatomically based computed tomography scans in evaluating Stage III (American Joint Committee on Cancer) patients with malignant melanoma. The purpose this study was to investigate efficacy and clinical utility functionally positron emission (PET) same patient population.A prospective evaluation 106 whole body PET obtained after injection 2-fluorine-18, 2-fluoro-2-deoxy-D-glucose (FDG) performed 95 clinically evident lymph node...
In Brief Objective: To determine whether 1 of 2 vaccines based on dendritic cells (DCs) and poxvectors encoding CEA (carcinoembryonic antigen) MUC1 (PANVAC) would lengthen survival in patients with resected metastases colorectal cancer (CRC). Background: Recurrences after complete resections metastatic CRC remain frequent. Immune responses to are associated fewer recurrences, suggesting a role for as adjuvant therapy. Both DCs potent stimulators immune against antigens. Methods: Patients,...