A5011399299- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Mechanical Circulatory Support Devices
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Xenotransplantation and immune response
- Polyomavirus and related diseases
- Heavy metals in environment
- Tracheal and airway disorders
- Organ and Tissue Transplantation Research
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Cardiac and Coronary Surgery Techniques
- Pneumocystis jirovecii pneumonia detection and treatment
- Gastroesophageal reflux and treatments
- Respiratory viral infections research
- Municipal Solid Waste Management
- Agricultural Science and Fertilization
- Intensive Care Unit Cognitive Disorders
- Dysphagia Assessment and Management
- Viral Infections and Immunology Research
- Cystic Fibrosis Research Advances
- Animal Genetics and Reproduction
- Cardiac Structural Anomalies and Repair
- Tissue Engineering and Regenerative Medicine
AdventHealth Orlando
2017-2024
Yale University
2024
Yale New Haven Hospital
2024
Duke Medical Center
2009-2022
Duke University
2007-2020
Istanbul University
2019
Children's Hospital of Philadelphia
2019
Medizinische Hochschule Hannover
2019
Georgetown University
2019
NHS Blood and Transplant
2019
Long-term success in xenotransplantation is currently hampered by acute vascular rejection. The inciting cause of rejection not yet known; however, a variety observations suggest that the humoral immune response recipient against donor may be involved pathogenesis this process. Using pig-to-baboon heterotopic cardiac transplant model, we examined role antibodies development After transplantation into baboons, hearts from transgenic pigs expressing human decay-accelerating factor and CD59...
Chronic allograft dysfunction after lung transplantation contributes to poor long-term survival. A link between gastric aspiration and post-transplant has been suggested, but little is known about the significance of gastroesophageal reflux disease (GERD) transplantation.A retrospective study was performed determine prevalence GERD in transplant recipients. Patients who underwent at Duke University, survived least 6 months had 24-h pH studies were included analysis. Antireflux medications...
Extracorporeal membrane oxygenation as a bridge to lung transplantation has traditionally been associated with substantial morbidity and mortality. A major contributor these complications may be weakness overall deconditioning secondary pretransplant critical illness immobility. In an attempt address this issue, we developed collaborative program allow for active rehabilitation physical therapy patients requiring life support extracorporeal before transplantation.An interdisciplinary team...
Background. Aerosolized administrations of amphotericin B deoxycholate (AmBd) and lipid complex (ABLC) in lung transplant recipients were compared for safety tolerability. The incidence invasive fungal infections patients receiving aerosolized formulations as sole prophylaxis was determined. Methods. A prospective, randomized (1:1), double-blinded trial conducted with 100 subjects. AmBd ABLC administered postoperatively by nebulizer at doses 25 mg 50 mg, respectively, which doubled...
Chronic allograft rejection manifested as bronchiolitis obliterans syndrome (BOS) is the leading cause of late death after lung transplantation. Although increasing evidence suggests an association between anti-human leukocyte antigens (HLA) antibodies and chronic kidney or heart allografts, clinical significance anti-HLA in recipients less clear, especially previously unsensitized recipients. The use flow cytometry based panel reactive antibody (flow-PRA) provides a highly sensitive means...
Patients with end-stage lung disease often progress to critical illness, which dramatically reduces their chance of survival following transplantation. Pre-transplant deconditioning has a significant impact on outcomes for all transplant patients, and is likely major contributor increased mortality in critically ill recipients. The aim this report describe series patients bridged extracorporeal membrane oxygenation (ECMO) examine the potential active rehabilitation ambulation during...
Within the Burkholderia cepacia complex (Bcc), B. cenocepacia portends increased mortality compared with other species. We investigated impact of Bcc infection on and re-infection following lung transplant (LT). Species designation for isolates from Bcc-infected patients was determined using 16S rDNA recA gene analyses. Of 75 cystic fibrosis undergoing LT September 1992 to August 2002, 59 had no 16 (including 7 cenocepacia) isolated in year before LT. latter, 87.5% recovered after...
In Brief Background Extracorporeal membrane oxygenation (ECMO) is being increasingly used as a bridge to lung transplantation. Small, single-institution series have described increased success using ECMO in spontaneously breathing patients compared with on mechanical ventilation, but this strategy has not been evaluated large scale. Methods Using the United Network for Organ Sharing database, all adult undergoing isolated transplantation from May 2005 through September 2013 were identified....
As HLAs antibody detection technology has evolved, there is now detailed HLA information available on prospective transplant recipients. Determining single antigen specificity allows for a calculated panel reactive antibodies (cPRA) value, providing an estimate of the effective donor pool. For broadly sensitized lung candidates (cPRA ≥ 80%), our center adopted pretransplant multi-modal desensitization protocol in effort to decrease cPRA and expand This included plasmapheresis, solumedrol,...
BackgroundThe United States Chronic Thromboembolic Pulmonary Hypertension Registry (US-CTEPH-R) was designed to characterize the demographic characteristics, evaluation, clinical course, and outcomes of surgical nonsurgical therapies for patients with chronic thromboembolic pulmonary hypertension.Research QuestionWhat are differences in baseline characteristics 1-year between operated nonoperated subjects?Study Design MethodsThis study describes a multicenter, prospective, longitudinal,...
Although innate immunity is crucial to pulmonary host defense and can initiate immune inflammatory responses independent of adaptive immunity, it remains unstudied in the context transplant rejection. To investigate role development allograft rejection, we assessed impact two functional polymorphisms toll-like receptor 4 (TLR4) associated with endotoxin hyporesponsiveness on acute rejection after human lung transplantation. Patients donors were screened for TLR4 Asp299Gly Thr399Ile by...
Fungal infections remain an important cause of morbidity and mortality in lung transplant recipients. Aerosolized amphotericin B lipid complex (ABLC) may be more efficacious than conventional the prevention fungal animal models, but experience with aerosolized ABLC humans is lacking.We conducted a prospective, noncomparative study designed to evaluate safety or heart-lung recipients.A total 381 treatments were administered 51 patients. Complete spirometry records available for 335 (69...
Abstract —Cardiac G protein–coupled receptors that couple to Gα s and stimulate cAMP formation (eg, β-adrenergic, histamine, serotonin, glucagon receptors) play a key role in cardiac inotropy. Recent studies rodent myocytes transfected cells have revealed one of these receptors, the β 2 -adrenergic receptor (AR), also couples inhibitory protein i (activation which inhibits formation). If ARs could be shown human heart, it would important ramifications, because levels increase with age...