A5040347516- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Advanced NMR Techniques and Applications
- Neural dynamics and brain function
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Metabolomics and Mass Spectrometry Studies
- Electron Spin Resonance Studies
- Lanthanide and Transition Metal Complexes
- Attention Deficit Hyperactivity Disorder
- Atomic and Subatomic Physics Research
- Medical Imaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- NMR spectroscopy and applications
- Transcranial Magnetic Stimulation Studies
- Biochemical effects in animals
- Neurological disorders and treatments
- Tryptophan and brain disorders
- Neuroscience and Neural Engineering
- GABA and Rice Research
- Genetics and Neurodevelopmental Disorders
- Obsessive-Compulsive Spectrum Disorders
- Vestibular and auditory disorders
- Visual perception and processing mechanisms
Johns Hopkins University
2016-2025
Kennedy Krieger Institute
2016-2025
Johns Hopkins Medicine
2014-2024
Douglas Mental Health University Institute
2021
University of Baltimore
2021
Cardiff University
2008-2014
University of Michigan
2012
University of Cambridge
2003-2005
The purpose of this study is to describe the Gannet toolkit for quantitative batch analysis gamma-aminobutyric acid (GABA) -edited MRS data.Using MEGA-PRESS editing and standard acquisition parameters, four spectra were acquired in three brain regions 10 healthy volunteers. These 120 datasets processed without user intervention with Gannet, a Matlab-based tool that takes raw time-domain data input, processes it generate frequency-domain edited spectrum, applies simple modeling procedure...
Functional imaging of the human brain is an increasingly important technique for clinical and cognitive neuroscience research, with functional MRI (fMRI) blood oxygen level-dependent (BOLD) response electroencephalography or magnetoencephalography (MEG) recordings neural oscillations being 2 most popular approaches. However, physiological mechanisms that generate these responses are only partially understood sources interparticipant variability in measures rarely investigated. Here, we test...
Neuronal orientation selectivity has been shown in animal models to require corticocortical network cooperation and be dependent on the presence of GABAergic inhibition. However, it is not known whether variability these fundamental neurophysiological parameters leads behavioral performance. Here, using a combination magnetic resonance spectroscopy, magnetoencephalography, visual psychophysics, we show that individual performance discrimination task correlated with both resting concentration...
Purpose To develop a tissue correction for GABA‐edited magnetic resonance spectroscopy (MRS) that appropriately addresses differences in voxel gray matter (GM), white (WM), and cerebrospinal fluid (CSF) fractions. Materials Methods Simulations compared the performance of approaches. Corrections were then applied to vivo data from 16 healthy volunteers, acquired at 3T. GM, WM, CSF fractions determined T 1 ‐weighted images. content, GM/WM GABA water relaxation three compartments are combined...
Purpose Frequency and phase drifts are a common problem in the acquisition of vivo magnetic resonance spectroscopy (MRS) data. If not accounted for, frequency will result artifactual broadening spectral peaks, distortion lineshapes, reduction signal‐to‐noise ratio (SNR). We present herein new method for estimating correcting MRS Methods used simple fitting each average to reference scan (often first series) time domain through adjustment terms. Due similarity with image registration, this is...
<h3>Context</h3>Attention-deficit/hyperactivity disorder (ADHD) is a developmental characterized by deficit in behavioral inhibition. Recent evidence also suggests cortical inhibition via the GABA (γ-aminobutyric acid)–ergic system.<h3>Objective</h3>To investigate GABAergic component of ADHD using magnetic resonance spectroscopy.<h3>Design</h3>Cross-sectional study.<h3>Setting</h3>Participants were recruited through local schools, pediatric and other community clinics, advertisement regional...
Impaired responses to tactile stimulation are a commonly reported symptom among children with autism spectrum disorder (ASD). Furthermore, impairments in filtering or habituation input have been described ASD. This study measured different aspects of processing investigate atypical touch sensitivity ASD, methodology that has not previously used this population. Sixty-seven typically developing (TDC) and 32 ASD (ages 8–12) completed vibrotactile tasks assessing: reaction time (RT); static...
Abnormal responses to tactile stimuli are a common feature of autism spectrum disorder (ASD). Several lines evidence suggest that GABAergic function, which has crucial role in processing, is altered ASD. In this study, we determine whether vivo GABA levels children with ASD, and alterations associated abnormal function these children.GABA-edited magnetic resonance spectroscopy was acquired 37 Autism 35 typically developing (TDC) from voxels over primary sensorimotor occipital cortices....
Abstract Purpose: To evaluate the reproducibility of γ‐amino‐butyric acid (GABA) and glutamate concentrations derived using three different spectral fitting methods, to investigate gender‐related differences in neurotransmitter levels. Materials Methods: Single voxel MEGA‐edited PRESS MR spectra were acquired from a 30‐mL dorso‐lateral prefrontal cortex 14 adult volunteers (7 female) at 3 Tesla (3T). For each participant, four consecutive resting within same scanning session. Metabolite...
Recent scientific findings have reinvigorated interest in examining the role of γ-aminobutyric acid (GABA), major inhibitory central nervous system neurotransmitter, chronic pain conditions. Decreased neurotransmission is a proposed mechanism pathophysiology syndromes such as fibromyalgia (FM). The purpose this study was to test hypothesis that decreased levels insular and anterior cingulate GABA would be present FM patients, concentration neurotransmitter correlated with pressure-pain...
The neural mechanisms underlying variability in human sensory perception remain incompletely understood. In particular, few studies have attempted to investigate the relationship between vivo measurements of neurochemistry and individuals' behavioral performance. Our previous work found a GABA concentration visual cortex orientation discrimination thresholds (Edden et al., 2009). present study, we used magnetic resonance spectroscopy psychophysical testing vibrotactile frequency whether...
Abstract The MEGA‐PRESS‐IVS method has been developed, which combines MEGA (a frequency‐selective editing technique) with the point‐resolved spectroscopy sequence (PRESS) and inner volume saturation (IVS) localization, reducing deleterious effects of spatial variation in coupling evolution. IVS previously described for improved efficiency lactate detection. current study demonstrates that combination MEGA‐PRESS results increased sensitivity edited single‐voxel measurements glutamate...
The major excitatory and inhibitory neurotransmitters, glutamate (Glu) gamma-aminobutyric acid (GABA), respectively, are implicated in the pathophysiology of schizophrenia. N-acetyl-aspartyl-glutamate (NAAG), a neuropeptide that modulates Glu system, may also be altered This study investigated GABA, + glutamine (Glx), NAAG levels younger older subjects with Forty-one subjects, 21 chronic schizophrenia 20 healthy controls, participated this study. Proton magnetic resonance spectroscopy...
Exposure to excessive levels of manganese (Mn) is known induce psychiatric and motor disorders, including parkinsonian symptoms. Therefore, finding a reliable means for early detection Mn neurotoxicity desirable.Our goal was determine whether in vivo brain γ-aminobutyric acid (GABA), N-acetylaspartate (NAA), other metabolites male smelters were altered as consequence exposure.We used T1-weighted magnetic resonance imaging (MRI) visualize deposition the brain. Magnetic spectroscopy (MRS)...