A5017460875- Semantic Web and Ontologies
- Biochemical effects in animals
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Vestibular and auditory disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- T-cell and B-cell Immunology
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced Neuroimaging Techniques and Applications
- Cancer, Lipids, and Metabolism
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Kidney Stones and Urolithiasis Treatments
- Clinical Reasoning and Diagnostic Skills
- Extracellular vesicles in disease
- Hemispheric Asymmetry in Neuroscience
- Peer-to-Peer Network Technologies
- Pain Mechanisms and Treatments
- Acupuncture Treatment Research Studies
- Artificial Intelligence in Healthcare and Education
Guangzhou Medical University
2021-2024
Shandong University
2012-2024
Sichuan University
2018-2023
West China Hospital of Sichuan University
2023
Qilu Hospital of Shandong University
2017-2022
Shaanxi University of Chinese Medicine
2022
Shandong First Medical University
2018-2021
Shandong Provincial Hospital
2020-2021
Harbin Medical University
2018-2020
Xinjiang University
2020
Purpose To determine whether there are in vivo differences of γ-aminobutyric acid (GABA) levels frontal and parietal regions Alzheimer's disease (AD) patients, compared with healthy controls using magnetic resonance spectroscopy (1H-MRS). Materials Methods Fifteen AD patients fifteen age- gender-matched underwent 1H-MRS the lobes "MEGA-Point Resolved Spectroscopy Sequence" (MEGA-PRESS) technique, cognitive subjects were evaluated Mini-Mental State Examination (MMSE) tests. MRS data processed...
Background: Coronavirus disease-2019 (COVID-19) epidemic is spreading globally. Sex differences in the severity and mortality of COVID-19 emerged. This study aims to describe impact sex on outcomes COVOD-19 with a special focus effect estrogen. Methods: We performed retrospective cohort which included 413 patients (230 males 183 females) from three designated hospitals China follow up time January 31, 2020, April 17, 2020. Women over 55 were considered as postmenopausal according previous...
Abstract Background Information regarding characteristics and risk factors of COVID-19 amongst middle-aged (40–59 years) patients without comorbidities is scarce. Methods We therefore conducted this multicentre retrospective study collected data at admission from three designated hospitals in China. Results Among 119 comorbidities, 18 (15.1%) developed into severe illness 5 (3.9%) died hospital. ARDS (26, 21.8%) elevated D-dimer (36, 31.3%) were the most common complications, while other...
Although electroacupuncture (EA) has been shown to be effective in the treatment of stroke, its mechanisms action remain undefined. This study explored therapeutic effects EA rats with cerebral ischemia-reperfusion injury (CIRI) and evaluated possible promoting angiogenesis. To evaluate effect EA, we used 2, 3, 5-Triphenyl-2H-Tetrazolium Chloride (TTC) staining behavior score calculate infarct volume neurological deficit after CIRI. Western blot (WB) analysis was employed expression cluster...
The purpose of the present study was to assess reproducibility voxel placement for GABA-edited MRS. MRS data were acquired in 13 healthy volunteers from (3 cm)3 voxel; and within same session a second acquisition independently prescribed. A three-dimensional mask image reconstructed T1-image-space using SVMask tool (in house software). Reproducibility assessed Dice overlap coefficient, both within-subject between-subject following co-registration T1 images transformation standard space....
Context: It is well known that regulatory T cells (Tregs) are abnormal in Graves' disease (GD) and play crucial roles the breakdown of immune tolerance GD development. However, there controversies about whether quantity and/or function Tregs aberrant GD. The molecular mechanism abnormality its effects on development was still unclear, until now. Objective: MiRNAs important system including Tregs. To reveal GD, we systematically studied immunosuppressive as differential expression profiles...
Dexmedetomidine (DEX) has been confirmed to exert neuroprotective effects in various nerve injury models by regulating ferroptosis, including spinal cord (SCI). Although it established that CDGSH iron sulfur domain 2 (CISD2) can regulate whether DEX ferroptosis CISD2 SCI remains unclear. Lidocaine was used induce PC12 cells and stimulate rats establish vitro vivo. MTT assays were performed analyze cell viability. Ferroptosis assessed determining the levels of cellular reactive axygen species...
Polybrominated diphenyl ethers (PBDEs) exist extensively in the environment as contaminants, which 2,2',3,3',4,4',5,5',6,6'-decabrominated ether (BDE-209) is most abundant PBDE found human samples. BDE-209 has been shown to cause neurotoxicity of primary sensory neurons with few effective therapeutic options available. Here, cultured dorsal root ganglion (DRG) were used determine effects insulin-like growth factor-1 (IGF-1) on BDE-209-induced neurotoxicity. The results showed that IGF-1...
Objectives: to determine the effects of vitamin B12 supplementation on neuropsychological function and disease progression in middle aged elderly patients with cognitive impairment. Methods: this was a prospective case-control study. From May 2020 2021, 307 participants clinically diagnosed impairment Department Neurology First Affiliated Hospital Chongqing Medical University were enrolled. A total 115 included Meanwhile, randomly assigned equal proportions two groups: treatment group (n =...
Paclitaxel (PT)-induced neurotoxicity is a significant problem associated with successful treatment of cancers. Insulin-like growth factor-1 (IGF-1) neurotrophic factor and plays an important role in promoting axonal from dorsal root ganglion (DRG) neurons. Whether IGF-1 has protective effects on neurite growth, cell viability, neuronal apoptosis phenotypes DRG neurons PT-induced still unclear. In this study, primary cultured rat were used to assess the neurotoxicity. The results showed that...
This study aimed to determine the clinical profiles and prevalence trends during 1994 2014 among patients with allergic asthma (AA), which is a phenotype of asthma.We retrospectively analyzed characteristics 319 who were diagnosed AA between March 1, February 28, at 3 Beijing centers.The included 155 males 164 females, mean age was 50.86 ± 15.27 years (range 13-86 years). The proportions attacks in summer autumn 60.7% (1994-1999), 61.8% (1999-2004), 56.4% (2004-2009), 33.1% (2009-2014). most...
To improve the diagnosis and classification of Alzheimer's disease (AD), a modeling method is proposed based on combining magnetic resonance images (MRI) brain structural data with metabolite levels frontal parietal regions. First, multi-atlas segmentation technology T1-weighted edited spectroscopy (MRS) were used to extract 279 regions 12 metabolites from interest (ROIs) in The t-test combined false discovery rate (FDR) correction was reduce dimensionality data, MRI 54 4 that obviously...
Killer cell immunoglobulin-like receptor (KIR) and human leucocyte antigen (HLA) play crucial role in maintaining immune homoeostasis controlling responses. To investigate the influence of KIR HLA-C ligands on risk pulmonary tuberculosis (PTB), we studied 200 patients who were confirmed to have PTB healthy controls different frequencies ligands. Genotyping these genes was conducted by sequence-specific primer polymerase chain reaction (SSP-PCR) method. Gene compared between group control...
Abstract Background &Aim: Hepatocellular carcinoma (HCC) is a common type of tumor with high incidence. Alpha-fetoprotein (AFP) and protein induced by vitamin K deficiency or antagonist-II (PIVKA-II DCP) are proven effective biomarkers for HCC. Combining them can enhance detection rates. However, when both AFP PIVKA-II negative, clinical diagnosis may be missed. This study aims to explore the risk factors negativity in HCC, thereby reducing missed diagnoses. Methods A retrospective...
Hepatocellular carcinoma (HCC) is a common type of tumor with high incidence. Alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II des-gamma-carboxy prothrombin) are proven effective biomarkers for HCC. Combining them can enhance detection rates. However, when both AFP PIVKA-II negative, clinical diagnosis may be missed. This study aims to explore the risk factors negativity in HCC, thereby reducing missed diagnoses. A retrospective enrolled 609 HCC...