A5100324873- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- stochastic dynamics and bifurcation
- Advanced Neuroimaging Techniques and Applications
- Ionosphere and magnetosphere dynamics
- Mental Health Research Topics
- Cholinesterase and Neurodegenerative Diseases
- Nanoplatforms for cancer theranostics
- Photoreceptor and optogenetics research
- Mitochondrial Function and Pathology
- Nonlinear Dynamics and Pattern Formation
- Memory and Neural Mechanisms
- Geophysics and Gravity Measurements
- Diet and metabolism studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- GNSS positioning and interference
- Advanced Memory and Neural Computing
- Computational Drug Discovery Methods
- Heart Rate Variability and Autonomic Control
- Nicotinic Acetylcholine Receptors Study
- Advanced MRI Techniques and Applications
Dalian University of Technology
2024-2025
Shaanxi University of Science and Technology
2025
Anhui Medical University
2025
Second Affiliated Hospital of Zhejiang University
2025
Second Institute of Oceanography
2025
Ministry of Natural Resources
2025
First Affiliated Hospital of Anhui Medical University
2025
Capital Medical University
2010-2024
Xi'an Jiaotong University
2013-2024
Xi'an University of Science and Technology
2019-2024
Mutations in the presenilin 1 (PS1) and 2 genes cosegregate with majority of early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that Aβ1–42(43)/Aβ1–40 ratio conditioned media independent N2a cell lines expressing three FAD-linked PS1 variants is uniformly elevated relative to cells similar levels wild-type PS1. Similarly, brains young transgenic animals coexpressing a chimeric amyloid precursor protein (APP) an variant compared mice APP alone or human APP. These...
Diverse cognitive processes set different demands on locally segregated and globally integrated brain activity. However, it remains unclear how resting brains configure their functional organization to balance the network segregation integration best serve cognition. Here, we use an eigenmode-based approach identify hierarchical modules in networks, quantify between integration. In a large sample of healthy young adults (n=991), combine whole-brain state magnetic resonance imaging (fMRI)...
The varied ways in which mutations presenilins (PSEN1 and PSEN2) affect amyloid b precursor protein (APP) processing causing early-onset familial Alzheimer disease (FAD) are complex not yet properly understood. Nonetheless, one useful diagnostic marker is an increased ratio of Ab42 to Ab40 (Ab42/Ab40) patients' brain biological fluids as well transgenic mice cells. We studied Ab APP for a set nine clinical PSEN on novel highly reproducible enzyme-linked immunosorbent assay (ELISA)-based...
This study was designed to explore the possibility that caloric restriction (CR) may benefit Alzheimer's disease (AD) by preventing beta-amyloid (Abeta) neuropathology pivotal initiation and progression of disease. We report a CR dietary regimen prevents Abeta peptides generation neuritic plaque deposition in brain mouse model AD through mechanisms associated with promotion anti-amyloidogenic alpha-secretase activity. Study findings support existing epidemiological evidence indicating intake...
The brain requires diverse segregated and integrated processing to perform normal functions in terms of anatomical structure self-organized dynamics with critical features, but the fundamental relationships between complex structural connectome, state, functional diversity remain unknown. Herein, we extend eigenmode analysis investigate joint contribution hierarchical modular organization state diversity. We show that modes inherent connectome allow a nested segregation integration across...
Amyloidogenic processing of the amyloid precursor protein (APP) with deposition in brain 42 amino acid long beta-peptide (A beta(42)) is considered central to Alzheimer's disease (AD) pathology. However, it generally believed that nonfibrillar pre-amyloid A beta(42) deposits have mature presence beta(40) into fibrillar plaques cause neurodegeneration. Here, we describe an aggressive form AD caused by a novel missense mutation APP (T714I) directly involving gamma-secretase cleavages APP. The...
Numerous studies have shown that drugs of abuse induce changes in protein expression the brain are thought to play a role synaptic plasticity. Drug-induced plasticity can be mediated by at synapse and more specifically postsynaptic density (PSD), which receives transduces information. To date, majority examining profiles focused on identifying proteome. Only handful examined profile drug administration. We applied quantitative proteomics analysis technique with cleavable ICAT reagent...
Binding of EphB receptors to ephrinB ligands on the surface adjacent cells initiates signaling cascades that regulate angiogenesis, axonal guidance, and neuronal plasticity. These functions require processing removal EphB-ephrinB complexes from cell surface, but mechanisms involved are poorly understood. Here we show ectodomain EphB2 receptor is released extracellular space following cleavage after residue 543. The remaining membrane-associated fragment cleaved by presenilin-dependent...
Abstract The gliotransmitter glutamate released from astrocytes can modulate neuronal firing by activating N-methyl-D-aspartic acid (NMDA) receptors. This enables astrocytic glutamate(AG) to be involved in physiological and pathological functions. Based on empirical results classical neuron-glial “tripartite synapse” model, we propose a practical model describe extracellular AG oscillation, which the fluctuation of depends threshold calcium concentration effect degradation is considered as...
Alzheimer's disease (AD) is characterized pathologically by an abundance of extracellular neuritic plaques composed primarily the 42-amino acid amyloid β peptide variant (Aβ42). In majority familial AD (FAD) cases, e.g., those harboring mutations in presenilin 1 (PS1), there a relative increase levels Aβ42 compared to Aβ40. We previously reported characterization series aminothiazole-bridged aromates termed aryl aminothiazole γ-secretase modulators or AGSMs [Kounnas, M. Z., et al. (2010)...
Bipolar disorder (BD) is a serious mental involving widespread abnormal interactions between brain regions, and it believed to be associated with imbalanced functions in the brain. However, how this imbalance underlies distinct BD symptoms remains poorly understood. Here, we used nested-spectral partition (NSP) method study segregation, integration, balance resting-state functional networks patients healthy controls (HCs). We first confirmed that there was high deviation network toward more...
Abstract Schizophrenia is a severe psychotic disorder characterized by positive and negative symptoms, but their neural bases remain poorly understood. Here, we utilized nested-spectral partition (NSP) approach to detect hierarchical modules in resting-state brain functional networks schizophrenia patients healthy controls, studied dynamic transitions of segregation integration as well relationships with clinical symptoms. brains showed more stable integrating process variable segregating...
The amyloid beta (Abeta) peptide is a key molecule in the pathogenesis of Alzheimer's disease. Reliable methods to detect and quantify soluble forms this human biological fluids model systems, such as cell cultures transgenic animals, are great importance for further understanding disease mechanisms. In study, application new highly specific ELISA systems quantification Abeta40 Abeta42 (Abeta peptides ending at residues 40 or 42, respectively) cerebrospinal fluid (CSF) presented.Monoclonal...
The temporal evolution properties of the brain network are crucial for complex processes. In this paper, we investigate differences in dynamic during resting and visual stimulation states a task-positive subnetwork, task-negative whole-brain network. is first constructed from human functional magnetic resonance imaging data based on sliding window method, then eigenvalues corresponding to calculated. We use eigenvalue analysis analyze global random matrix theory (RMT) method measure local...
Despite the prevalence of stress, how brains reconfigure their multilevel, hierarchical functional organization in response to acute stress remains unclear. We examined changes brain networks after social using whole-brain resting-state MRI (fMRI) by extending our recently published nested-spectral partition method, which quantified balance between network segregation and integration. Acute was found shift into a more integrated less segregated state, especially frontal-temporal regions....
Abstract The Hunga Tonga‐Hunga Ha'apai (hereafter HTHH) submarine volcano erupted at 04:14:45 UT on 15 January 2022, causing ionospheric disturbances. This paper uses carrier phase observations from GNSS tracking stations in New Zealand and Australia to calculate the vertical total electron content. At 06:10, ground‐based station observes a maximum amplitude of 2.26 TECU anomaly caused by mesoscale traveling disturbance (MSTID) with wavelength 200–250 km, period 6–13 min, propagation...