A5023940237- Circadian rhythm and melatonin
- Dietary Effects on Health
- Sleep and Wakefulness Research
- Adipose Tissue and Metabolism
- Light effects on plants
- Genetics, Aging, and Longevity in Model Organisms
- Photoreceptor and optogenetics research
- Pancreatic function and diabetes
- Diet and metabolism studies
- Plant Molecular Biology Research
- Regulation of Appetite and Obesity
- Sleep and related disorders
- Metabolism, Diabetes, and Cancer
- Endoplasmic Reticulum Stress and Disease
- Diet, Metabolism, and Disease
- Sirtuins and Resveratrol in Medicine
- Nuclear and radioactivity studies
- Heat shock proteins research
- Neuroendocrine regulation and behavior
- Mitochondrial Function and Pathology
- Spaceflight effects on biology
- Diabetes and associated disorders
- Graphite, nuclear technology, radiation studies
- Chemokine receptors and signaling
- Heart Rate Variability and Autonomic Control
Northwestern University
2016-2025
Idaho National Laboratory
2022-2023
United States Nuclear Regulatory Commission
2023
University of Chicago
1979-2019
Evanston Hospital
2003-2011
University of Asmara
2011
Canadian Sleep & Circadian Network
2011
Florida State University
2011
Northwest University
2011
Circadian (United States)
2010
The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, develop metabolic syndrome hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, hypoinsulinemia. Expression transcripts encoding selected peptides associated with energy balance was in mice. These results suggest gene...
The circadian clock is encoded by a transcription-translation feedback loop that synchronizes behavior and metabolism with the light-dark cycle. Here we report both rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis, phosphoribosyltransferase (NAMPT), levels of NAD+ display oscillations are regulated core machinery mice. Inhibition NAMPT promotes oscillation gene Per2 releasing CLOCK:BMAL1 from suppression SIRT1. In turn, transcription factor CLOCK binds...
Studies of body weight regulation have focused almost entirely on caloric intake and energy expenditure. However, a number recent studies in animals linking the circadian clock at molecular, physiological, behavioral levels raise possibility that timing food itself may play significant role gain. The present study phase consumption We provide evidence nocturnal mice fed high-fat diet only during 12-h light gain significantly more than dark phase. A better understanding system for could...
Circadian clocks are self-sustained cellular oscillators that synchronize oxidative and reductive cycles in anticipation of the solar cycle. We found clock transcription feedback loop produces nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, adenosine triphosphate production, mitochondrial respiration through modulation protein acetylation to metabolic pathways with 24-hour fasting feeding control activity NAD(+)-dependent deacetylase sirtuin 3 (SIRT3) generated rhythms enzymes...
The mammalian transcription factors CLOCK and BMAL1 are essential components of the molecular clock that coordinate behavior metabolism with solar cycle. Genetic or environmental perturbation circadian cycles contributes to metabolic disorders including type 2 diabetes. To study impact cell-autonomous on pancreatic β cell function, we examined islets from mice either intact disrupted expression both throughout life limited adulthood. We found pronounced oscillation insulin secretion was...
Misalignment of feeding rhythms with the light-dark cycle leads to disrupted peripheral circadian clocks and obesity. Conversely, restricting active period mitigates metabolic syndrome through mechanisms that remain unknown. We found genetic enhancement adipocyte thermogenesis ablation zinc finger protein 423 (ZFP423) attenuated obesity caused by consumption a high-fat diet during inactive (light) increasing futile creatine cycling in mice. Circadian control metabolism underlies timing...
Interactions between lineage-determining and activity-dependent transcription factors determine single-cell identity function within multicellular tissues through incompletely known mechanisms. By assembling a atlas of chromatin state human islets, we identified β cell subtypes governed by either high or low activity the factor pancreatic duodenal homeobox-1 (PDX1). cells with reduced PDX1 displayed increased accessibility at latent nuclear κB (NF-κB) enhancers. Pdx1 hypomorphic mice...