A5078500569- Circadian rhythm and melatonin
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Genetics, Aging, and Longevity in Model Organisms
- Metabolomics and Mass Spectrometry Studies
- Dietary Effects on Health
- Organ Transplantation Techniques and Outcomes
- Gut microbiota and health
- Gene Regulatory Network Analysis
- Renal Transplantation Outcomes and Treatments
- Orthopedic Surgery and Rehabilitation
- Healthcare Policy and Management
- Diet and metabolism studies
- Inflammatory Bowel Disease
- Photoreceptor and optogenetics research
- Liver Diseases and Immunity
- COVID-19 Impact on Reproduction
- Health Systems, Economic Evaluations, Quality of Life
- Cellular Mechanics and Interactions
- Global Health Workforce Issues
- Hepatocellular Carcinoma Treatment and Prognosis
- Reproductive Health and Contraception
- Intestinal Malrotation and Obstruction Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- bioluminescence and chemiluminescence research
University of Chicago
2014-2025
University of Chicago Medical Center
2015-2025
Yahoo (United Kingdom)
2024
Chicago Institute for Psychoanalysis
2015-2023
National Student Clearinghouse Research Center
2017
Geophysical Laboratory
2017
Yale University
2010-2011
The mammalian transcription factors CLOCK and BMAL1 are essential components of the molecular clock that coordinate behavior metabolism with solar cycle. Genetic or environmental perturbation circadian cycles contributes to metabolic disorders including type 2 diabetes. To study impact cell-autonomous on pancreatic β cell function, we examined islets from mice either intact disrupted expression both throughout life limited adulthood. We found pronounced oscillation insulin secretion was...
Robust methods for identifying patterns of expression in genome-wide data are important generating hypotheses regarding gene function. To this end, several analytic have been developed detecting periodic patterns. We improve one such method, JTK_CYCLE, by explicitly calculating the null distribution that it accounts multiple hypothesis testing and including non-sinusoidal reference waveforms. term method empirical JTK_CYCLE with asymmetry search, we compare its performance to Bonferroni...
ABSTRACT Diversity is often associated with the functional stability of ecological communities from microbes to macroorganisms. Understanding how diversity responds environmental perturbations and consequences this relationship for ecosystem function are thus central challenges in microbial ecology. Unimodal diversity-disturbance relationships, which maximum occurs at intermediate levels disturbance, have been predicted ecosystems where life history tradeoffs separate organisms along a...
Summary Purpose: Impaired consciousness in epileptic seizures has a major negative impact on patient quality of life. Prior work unconsciousness mainly used retrospective and nonstandardized methods. Our goal was to validate obtain initial data using standardized prospective testing battery. Methods: The responsiveness epilepsy scale (RES) 52 patients during continuous video–electroencephalography (EEG) monitoring. RES begins with higher‐level questions commands, switches adaptively more...
Neurodegenerative diseases commonly involve the disruption of circadian rhythms. Studies indicate that mutant Huntingtin (mHtt), cause Huntington's disease (HD), disrupts rhythms often before motor symptoms are evident. Yet little is known about molecular mechanisms by which mHtt impairs rhythmicity and whether clocks can modulate HD pathogenesis. To address this question, we used a Drosophila model. We found both environmental genetic perturbations clock alter mHtt-mediated...
ABSTRACT Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from human pathogens Staphylococcus aureus and Pseudomonas aeruginosa can be readily inhibited by reactive oxygen species (ROS)-mediated direct oxidation of their catalytic active cysteines. Because the rapid degradation H 2 O bacterial catalase, only steady-state but not one-dose treatment with rapidly induces glycolysis pentose phosphate pathway (PPP). We conducted transcriptome sequencing (RNA-seq) analyses to globally profile...
There is much interest in using genome-wide expression time series to identify circadian genes. However, the cost and effort of such measurements often limit data collection. Consequently, it difficult assess experimental uncertainty and, turn, detect periodic patterns with statistical confidence. We show that parametric bootstrapping empirical Bayes methods for variance shrinkage can improve rhythm detection series. demonstrate these approaches by building on JTK_CYCLE method (eJTK)...
AbstractMorning Report is a time-honored tradition where physicians-in-training present cases to their colleagues and clinical experts collaboratively examine an interesting patient presentation. The Morning section seeks carry on this by presenting patient's chief concern story, inviting the reader develop differential diagnosis discover alongside authors of case. This report examines story 26-year-old woman who developed acute hepatocellular liver injury following cesarean delivery for...
Abstract Background Over the last decade, infectious disease (ID) fellowship match rates have declined despite increasing workforce need. Many factors may influence rates, including effects of local political climate. Since 2022, many states restricted reproductive and/or LGBT+ rights. As 43% ID physicians identified as women in 2021 (AMA) and 6% graduating medical students entering medicine residencies lesbian, gay, or bisexual from 2016-2019 (Mori, 2021), there is a need to examine impact...
In the US, pre-diabetes and diabetes are increasing in prevalence alongside other chronic diseases. Hemoglobin A1c is most common diagnostic test for performed but it has known inaccuracies setting of To determine if easily obtained clinical data could be used to improve diagnosis compared hemoglobin alone. This cross-sectional study analyzed nationally representative from six 2-year cycles (2005 2006 through 2015 2016) National Health Nutrition Examination Survey US. We excluded...
As mechanisms of neoplasia in patients with ulcerative colitis (UC) remain poorly understood, we sought to identify pathways carcinogenesis this high-risk population.MicroRNA (miRNA) and mRNA expression was examined nondysplastic rectosigmoid mucosa from UC (n = 19) or without remote colon 23). We developed a method miRNA-regulated based on differentially expressed miRNAs their putative mRNAs targets the same samples. One key pathway identified analysis, miR-4728-3p regulation focal adhesion...
Liver transplantation (LT) is the only curative treatment for end-stage liver disease and significantly improves patient outcomes. However, LT resource-intensive costly, with expenditures rising dramatically in recent years. Factors contributing to this increase cost include expanded transplant criteria, utilization of marginal organs, broader organ distribution, resulting significant logistical expenses. Advanced technologies like perfusion devices, while promising better outcomes, further...
Abstract Circadian clocks may mediate lifespan extension by caloric or dietary restriction (DR). We find that the core clock transcription factor Clock is crucial for a robust longevity and fecundity response to DR in Drosophila . To identify clock-controlled mediators, we performed RNA-sequencing from abdominal fat bodies across 24 h day after just 5 days under control diets. In contrast more chronic regimens, did not detect significant changes rhythmic expression of genes. Yet discovered...