A5040877927- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Spaceflight effects on biology
- Sleep and related disorders
- Gut microbiota and health
- Cerebrovascular and Carotid Artery Diseases
- Dietary Effects on Health
- Intracranial Aneurysms: Treatment and Complications
- Mitochondrial Function and Pathology
- Neurobiology and Insect Physiology Research
- Venous Thromboembolism Diagnosis and Management
- Genetics, Aging, and Longevity in Model Organisms
- Central Venous Catheters and Hemodialysis
- Traumatic Brain Injury and Neurovascular Disturbances
- Adipose Tissue and Metabolism
- Moyamoya disease diagnosis and treatment
- Bioinformatics and Genomic Networks
- Tryptophan and brain disorders
- Mental Health Research Topics
- Regulation of Appetite and Obesity
- Light effects on plants
- Parkinson's Disease Mechanisms and Treatments
- Health, Environment, Cognitive Aging
- Conducting polymers and applications
- Genetic Neurodegenerative Diseases
Capital Medical University
2025
Beijing Institute of Neurosurgery
2025
Beijing Tian Tan Hospital
2025
Northwestern University
2015-2024
Peking University
2013-2023
Beijing Jishuitan Hospital
2020-2023
Circadian (United States)
2018-2021
Canadian Sleep & Circadian Network
2013-2019
Chinese Academy of Fishery Sciences
2014
University of Kentucky
2009-2012
To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard International Space Station; his served as genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension increased intima-media thickness, altered ocular structure, transcriptional metabolic DNA...
Space environment imposes a range of challenges to mammalian physiology and the gut microbiota, interactions between two are thought be important in health space. While previous findings have demonstrated change microbial community structure during spaceflight, specific environmental factors that alter microbiome functional relevance changes spaceflight remain elusive.We profiled using 16S rRNA gene amplicon sequencing fecal samples collected from mice after 37-day onboard International...
It has been established in recent years that the gut microbiome plays a role health and disease, potentially via alterations metabolites influence host physiology. Although sleep disruption dysbiosis have associated with many of same diseases, studies investigating context yielded inconsistent results, not assessed fecal metabolome. We exposed mice to five days followed by four ad libitum recovery sleep, metabolome at multiple timepoints using 16S rRNA gene amplicons untargeted LC-MS/MS mass...
Sleep dysfunction and stress susceptibility are comorbid complex traits that often precede predispose patients to a variety of neuropsychiatric diseases. Here, we demonstrate multilevel organizations genetic landscape, candidate genes, molecular networks associated with 328 sleep in chronically stressed population 338 (C57BL/6J × A/J) F2 mice. We constructed striatal gene co-expression networks, revealing functionally cell-type-specific co-regulations important for sleep. Using composite...
Artificial intelligence can help to identify irregular shapes and sizes, crucial for managing unruptured intracranial aneurysms (UIAs). However, existing artificial tools lack reliable classification of UIA shape irregularity validation against gold-standard three-dimensional rotational angiography (3DRA). This study aimed develop validate a deep-learning model using computed tomography (CTA) classifying measuring size. CTA 3DRA patients from referral hospital were included as derivation...
Sleep disruption is a challenging and exceedingly common physiological state that contributes to wide range of biochemical molecular perturbations has been linked numerous adverse health outcomes. Modern society exerts significant pressure on the sleep/wake cycle via myriad factors, including exposure electric light, psychological stressors, technological interconnection, jet travel, shift work, widespread use sleep-affecting compounds. Interestingly, recent research identified link between...
Introduction The relationships between the feeding rhythm, sleep and cognition in Alzheimer’s disease (AD) are incompletely understood, but meal time could provide an easy-to-implement method of curtailing disease-associated disruptions cognition. Furthermore, known sex differences AD incidence relate to circadian rhythm/sleep/cognition interactions. Methods 5xFAD transgenic mouse model non-transgenic wild-type controls were studied. Both female male mice used. Food access was restricted...
Recent systems-based analyses have demonstrated that sleep and stress traits emerge from shared genetic transcriptional networks, clinical work has elucidated the emergence of dysfunction susceptibility as early symptoms Huntington's disease. Understanding biological bases these non-motor may reveal therapeutic targets prevent disease onset or slow progression, but molecular mechanisms underlying this complex presentation remain largely unknown. In present work, we specifically examine...
We identified gene networks linking sleep and affect, highlighting those oppositely perturbed by loss depression.
The present study was designed to explore the regulatory mechanisms and influences of cotinine on deep vein thrombosis (DVT) in rats via toll-like receptor 4/nuclear factor κ binding (TLR-4/NF-κB) pathway.
Background Chronic alcohol exposure exerts numerous adverse effects, although the specific mechanisms underlying these negative effects on different tissues are not completely understood. Alcohol also affects core properties of circadian clock system, and it has been shown that disruption rhythms confers vulnerability to alcohol-induced pathology gastrointestinal barrier liver. Despite findings, little is known molecular interactions between especially regarding implications for...
The inferior vena cava filter is utilized worldwide to intercept thrombi and reduce the risk of fatal pulmonary embolism (PE). However, filter-related thrombosis a complication implantation. Endovascular methods such as AngioJet rheolytic thrombectomy (ART) catheter-directed thrombolysis (CDT) can treat caval thrombosis, but clinical outcomes both treatment modalities have not been determined.To compare vs in patients with thrombosis.In this single-center retrospective study, 65 (34 males 31...
Study Objective: The adaptive value of the endogenous circadian clock arises from its ability to synchronize (i.e., entrain) external light-dark (LD) cycles at an appropriate phase.Studies have suggested that advanced phase alignment might result shortening period length clock.Here we explore mechanisms contribute early activity in CAST/EiJ (CAST) mice.Methods: We investigated rhythms wheel-running C57BL/6J (B6), CAST and 2 strains B6.CAST congenic mice, which carry segments introgressed a...
We have previously established that CAST/EiJ (CAST) mice differ from normal mice, such as C57BL/6J (B6), in the timing of wheel-running onset relative to light/dark cycles. These provide an animal model for studies genetic and neurobiological basis circadian phase misalignment humans. Neither differences endogenous period nor shape photic response curve explain difference activity between CAST B6 suggesting a mechanism downstream clock. Here, we further test hypothesis two strains with...
Abstract Circadian clocks may mediate lifespan extension by caloric or dietary restriction (DR). We find that the core clock transcription factor Clock is crucial for a robust longevity and fecundity response to DR in Drosophila . To identify clock-controlled mediators, we performed RNA-sequencing from abdominal fat bodies across 24 h day after just 5 days under control diets. In contrast more chronic regimens, did not detect significant changes rhythmic expression of genes. Yet discovered...