A5062131424- Gut microbiota and health
- Circadian rhythm and melatonin
- Dietary Effects on Health
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Parkinson's Disease Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Spaceflight effects on biology
- COVID-19 Clinical Research Studies
- Digestive system and related health
- Cell Adhesion Molecules Research
- Diet, Metabolism, and Disease
- SARS-CoV-2 and COVID-19 Research
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal motility and disorders
- Health, psychology, and well-being
- Barrier Structure and Function Studies
- Antifungal resistance and susceptibility
- Inflammatory Bowel Disease
- Dysphagia Assessment and Management
- Osteoarthritis Treatment and Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Protease and Inhibitor Mechanisms
- Sleep and related disorders
- Long-Term Effects of COVID-19
Rush University Medical Center
2015-2024
Rush University
2011-2024
Montefiore Medical Center
2019
John Wiley & Sons (United States)
2019
New York Academy of Sciences
2019
Albert Einstein College of Medicine
2019
Hudson Institute
2019
State Street (United States)
2018
Gosford Hospital
2018
Laboratoire de Biochimie
2013
Abstract Introduction We showed that Parkinson's disease (PD) patients have alpha‐synuclein (α‐Syn) aggregation in their colon with evidence of colonic inflammation. If PD altered microbiota, dysbiosis might be the mechanism neuroinflammation leads to α‐Syn misfolding and pathology. Methods Sixty‐six sigmoid mucosal biopsies 65 fecal samples were collected from 38 34 healthy controls. Mucosal‐associated feces microbiota compositions characterized using high‐throughput ribosomal RNA gene...
Parkinson's disease (PD) is the second most common neurodegenerative disorder of aging. The pathological hallmark PD neuronal inclusions termed Lewy bodies whose main component alpha-synuclein protein. finding these in intestinal enteric nerves led to hypothesis that intestine might be an early site response environmental toxin or pathogen. One potential mechanism for toxin(s) and proinflammatory luminal products gain access mucosal tissue promote oxidative stress compromised barrier...
HIV progression is characterized by immune activation and microbial translocation. One factor that may be contributing to could a dysbiotic microbiome. We therefore hypothesized the GI mucosal microbiome altered in patients this alteration correlates with HIV. 121 specimens were collected from 21 positive 22 control human subjects during colonoscopy. The composition of lower gastrointestinal tract luminal bacterial was using 16S rDNA pyrosequencing correlated clinical parameters as well...
Objective Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible gut-brain axis neurodegenerative diseases. Given prominence dysbiosis and colonic dysfunction patients with Parkinson’s disease (PD), we propose that toll-like receptor 4 (TLR4)-mediated intestinal could contribute central PD-related neurodegeneration. Design To test this hypothesis performed studies both human tissue a murine model PD....
Intestinal dysbiosis and circadian rhythm disruption are associated with similar diseases including obesity, metabolic syndrome, inflammatory bowel disease. Despite the overlap, potential relationship between disorganization is unknown; thus, in present study, a model of chronic was used to determine impact on intestinal microbiome. Male C57BL/6J mice underwent once weekly phase reversals light:dark cycle (i.e., disrupted mice) microbiome were fed either standard chow or high-fat, high-sugar...
Clinical and animal data indicate that gut-derived endotoxin other luminal bacterial products are necessary cofactors for development of alcoholic liver disease (ALD). Although gut leakiness is clearly an important cause endotoxemia in ALD, it cannot fully explain all ALD subjects thus factors may be involved. One possible factor a change microbiota composition (dysbiosis). Thus, the aim our study was to interrogate alcohol-fed rats see if chronic alcohol consumption affects bacteria...
The circadian clock orchestrates temporal patterns of physiology and behavior relative to the environmental light:dark cycle by generating organizing transcriptional biochemical rhythms in cells tissues throughout body. Circadian genes have been shown regulate function gastrointestinal tract. Disruption intestinal epithelial barrier enables translocation proinflammatory bacterial products, such as endotoxin, across wall into systemic circulation; a process that has linked pathologic...
Epidemiological studies propose a protective role for dietary fiber in colon cancer (CRC). One possible mechanism of is its fermentation property the gut and ability to change microbiota composition function. Here, we investigate mixture polyposis elucidate potential mechanisms using TS4Cre × cAPCl°x468 mice. Stool profiling was performed, while functional prediction done PICRUSt. short-chain fatty acid (SCFA) metabolites were measured. Histone acetylation expression SCFA butyrate receptor...
A disruption of the crosstalk between gut and lung has been implicated as a driver severity during respiratory-related diseases. Lung injury causes systemic inflammation, which disrupts barrier integrity, increasing permeability to microbes their products. This exacerbates resulting in positive feedback. We aimed test whether severe Coronavirus disease 2019 (COVID-19) is associated with markers disrupted permeability. applied multi-omic systems biology approach analyze plasma samples from...
Abstract A pro-inflammatory intestinal microbiome is characteristic of Parkinson’s disease (PD). Prebiotic fibers change the and this study sought to understand utility prebiotic for use in PD patients. The first experiments demonstrate that fermentation patient stool with increased production beneficial metabolites (short chain fatty acids, SCFA) changed microbiota demonstrating capacity respond favorably prebiotics. Subsequently, an open-label, non-randomized was conducted newly diagnosed,...
Alcohol-induced gut leakiness is a key factor in alcoholic liver disease (ALD); it allows endotoxin to enter the circulation and initiate damage. Zonula occludens 1 (ZO-1) protein major component of tight junctions that regulates intestinal permeability. microRNAs (miRNAs) are recently discovered regulatory molecules inhibit expression their target genes. (i) investigate effect alcohol on miRNA-212 (miR-212) its predicted gene, ZO-1, (ii) study potential role miR-212 pathophysiology ALD man....
Exposure to particulate matter (PM) air pollution may be an important environmental factor leading exacerbations of inflammatory illnesses in the GI tract. PM can gain access gastrointestinal (GI) tract via swallowing or secretions from upper airways mucociliary clearance inhaled particles. We measured PM-induced cell death and mitochondrial ROS generation Caco-2 cells stably expressing oxidant sensitive GFP localized mitochondria absence presence antioxidant. C57BL/6 mice were exposed a...
In the United States, there are persistent and widening socioeconomic gaps in morbidity mortality from chronic diseases. Although most disparities research focuses on person-level socioeconomic-status, mounting evidence suggest that diseases also pattern by demographic characteristics of neighborhoods. Yet biological mechanisms underlying these associations poorly understood. There is increasing recognition share common pathogenic features, some which involve alterations composition,...
Circadian rhythm disruption is a prevalent feature of modern day society that associated with an increase in pro-inflammatory diseases, and there clear need for better understanding the mechanism(s) underlying this phenomenon. We have previously demonstrated both environmental genetic circadian causes intestinal hyperpermeability exacerbates alcohol-induced liver pathology. The microbiota can influence barrier integrity impact immune system function; thus, study, we sought to determine...
A state of hyperinflammation and increased complement activation has been associated with coronavirus disease 2019 (COVID-19) severity. However, the pathophysiological mechanisms that contribute to this phenomenon remain mostly unknown.
Emerging evidence suggests intestinal microbiota as a central contributing factor to the pathogenesis of Relapsing-Remitting-Multiple-Sclerosis (RRMS). This novel RRMS study evaluated impact fecal-microbiota-transplantation (FMT) on broad array physiological/clinical outcomes using deep metagenome sequencing fecal microbiome. FMT interventions were associated with increased abundances putative beneficial stool bacteria and short-chain-fatty-acid metabolites, which increased/improved serum...