A5058585528- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
- Infant Nutrition and Health
- Nanowire Synthesis and Applications
- HIV/AIDS drug development and treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Dietary Effects on Health
- Viral Infectious Diseases and Gene Expression in Insects
- Viral gastroenteritis research and epidemiology
The Wistar Institute
2020-2021
A disruption of the crosstalk between gut and lung has been implicated as a driver severity during respiratory-related diseases. Lung injury causes systemic inflammation, which disrupts barrier integrity, increasing permeability to microbes their products. This exacerbates resulting in positive feedback. We aimed test whether severe Coronavirus disease 2019 (COVID-19) is associated with markers disrupted permeability. applied multi-omic systems biology approach analyze plasma samples from...
Abstract Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such can improve the safety of analytic treatment (ATI) and provide mechanistic insights into host pathways involved in post-ART control. Here we report plasma glycomic metabolic signatures time-to-viral-rebound probability-of-viral-remission using samples from two independent cohorts. These include a large number post-treatment controllers, rare population...
ABSTRACT A disruption of the crosstalk between gut and lung has been implicated as a driver severity during respiratory-related diseases. Lung injury causes systemic inflammation, which disrupts barrier integrity, increasing permeability to microbes their products. This exacerbates resulting in positive feedback. We aimed test whether severe Coronavirus disease 2019 (COVID-19) is associated with markers disrupted permeability. applied multi-omic systems biology approach analyze plasma...
Objective: HIV cure research urgently needs to identify pre-analytic treatment interruption (ATI) biomarkers of time-to-viral-rebound and viral setpoint mitigate the risk ATI accelerate development a cure. We previously reported that galactosylated IgG glycans, G2, negatively correlate with cell-associated DNA RNA during antiretroviral therapy (ART). hypothesized this other plasma glycomic traits can predict upon ART cessation. Design: profiled circulating glycomes (plasma bulk IgG) two...
An emerging paradigm suggests that gut glycosylation is a key force in maintaining the homeostatic relationship between and its microbiota. Nevertheless, it unclear how contributes to HIV-associated microbial translocation inflammation persist despite viral suppression contribute development of several comorbidities. We examined terminal ileum, right colon, sigmoid colon biopsies from HIV-infected virally-suppressed individuals found glycomic patterns are associated with distinct...
Abstract Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using intact proviral DNA assay (IPDA), along with assays for total or integrated DNA, and inducible RNA p24. Intact provirus correlated HIV.
BackgroundA comprehensive understanding of host factors modulated by the antiviral cytokine interferon-α (IFNα) is imperative for harnessing its beneficial effects while avoiding detrimental side-effects during HIV infection. Cytokines modulate glycosylation which plays a critical role in mediating immunological functions. However, impact IFNα on has never been characterized.MethodsWe assessed pegylated IFNα2a IgG glycome, as well CD8+ T and NK cell-surface glycomes, 18 HIV-infected...
Objective: Glycosylation plays a critical role in mediating several antibody (mainly immunoglobulin G; IgG) immunological functions, including antibody-dependent cell-mediated cytotoxicity (ADCC), and anti-inflammatory activities. We investigated whether IgG glycosylation immune profile patterns are differentially modulated mono dual infection using samples from untreated hepatitis C virus (HCV)-infected individuals with without co-infection antiretroviral therapy (ART)-suppressed HIV....
ABSTRACT Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such can improve the safety of analytic treatment (ATI) and provide mechanistic insights into pathways involved in post-ART control. We identified plasma glycomic metabolic signatures time-to-viral-rebound probability-of-viral-rebound using samples from two independent cohorts. These include a large number post-treatment controllers, rare population demonstrating...
Abstract Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such can improve the safety of analytic treatment (ATI) and provide mechanistic insights into pathways involved in post-ART control. We identified plasma glycomic metabolic signatures time-to-viral-rebound probability-of-viral-rebound using samples from two independent cohorts. These include a large number post-treatment controllers, rare population demonstrating...
Abstract Non-invasive biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are urgently needed. Such can improve the safety of analytic treatment (ATI) and provide mechanistic insights into pathways involved in post-ART control. We identified plasma glycomic metabolic signatures time-to-viral-rebound probability-of-viral-rebound using samples from two independent cohorts. These include a large number post-treatment controllers, rare population demonstrating...