A5077828570- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Airway Management and Intubation Techniques
- Geology and Paleoclimatology Research
- Hemodynamic Monitoring and Therapy
- Geological and Geochemical Analysis
- Mechanical Circulatory Support Devices
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Renal function and acid-base balance
- Immune Response and Inflammation
- Family and Patient Care in Intensive Care Units
- Neonatal Respiratory Health Research
- Geochemistry and Geologic Mapping
- COVID-19 Clinical Research Studies
- Adrenal Hormones and Disorders
- Tracheal and airway disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Phonocardiography and Auscultation Techniques
- Emergency and Acute Care Studies
- Thermal Regulation in Medicine
- Long-Term Effects of COVID-19
Rush University Medical Center
2016-2025
Rush University
1992-2023
Marquette University
2023
Wilford Hall Ambulatory Surgical Center
2023
Brooke Army Medical Center
2023
Prince Charles Hospital
2021
Cooper University Hospital
1995-2016
Center for Clinical Research (United States)
2016
Cooper Medical School of Rowan University
2016
Hadassah Medical Center
2016
Community-acquired pneumonia is a leading infectious cause of hospitalization and death among U.S. adults. Incidence estimates confirmed radiographically with the use current laboratory diagnostic tests are needed.
The use of high-dose corticosteroids in the treatment severe sepsis and septic shock remains controversial. Our study was designed as a prospective, randomized, double-blind, placebo-controlled trial methylprednisolone sodium succinate for shock. Diagnosis based on clinical suspicion infection plus presence fever or hypothermia (rectal temperature >38.3°C [101°F] <35.6°C [96°F]), tachypnea (>20 breaths per minute), tachycardia (>90 beats one following indications organ dysfunction: change...
A recombinant, soluble fusion protein that is a dimer of an extracellular portion the human tumor necrosis factor (TNF) receptor and Fc IgG1 (TNFR:Fc) binds neutralizes TNF-α prevents death in animal models bacteremia endotoxemia.
To determine the therapeutic efficacy and safety of recombinant human interleukin-1 receptor antagonist (rhIL-1ra) in treatment patients with severe sepsis.Prospective, randomized, double-blind, placebo-controlled, multicenter trial a planned, midstudy, interim analysis.Ninety-one academic medical center intensive care units North America Europe.Patients sepsis or septic shock (n = 696) received standard supportive antimicrobial therapy for sepsis, addition to rhIL-1ra placebo.Patients were...
To evaluate the efficacy and safety of anti-tumor necrosis factor alpha monoclonal antibody (TNF-alpha MAb) in treatment patients with sepsis syndrome.Randomized, prospective, multicenter, double-blind, placebo-controlled clinical trial.A total 31 hospitals United States Canada.There were 994 syndrome enrolled this trial, 971 infused study drug.Patients prospectively stratified into shock or nonshock groups then randomized to receive a single infusion 15 mg/kg TNF-alpha MAb, 7.5 placebo....
The sepsis syndrome represents a systemic response to infection and is defined as hypothermia (temperature <960F) or (>1010F), tachycardia (>90 beat/min), tachypnea (>20 breath/min), clinical evidence of an site with at least one end-organ demonstrating inadequate perfusion dysfunction expressed poor altered cerebral function, hypoxemia (Pao2 <75 torr), elevated plasma lactate, oliguria (urine output <30 ml/h 0.5 ml/kg body weight. h without corrective therapy). One hundred ninety-one...
To update the 2008 consensus statements for diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in adult pediatric patients.A multispecialty task force 16 international experts care medicine, endocrinology, guideline methods, all them members Society Critical Care Medicine and/or European Intensive Medicine.The recommendations were based on summarized evidence from document addition to more recent findings an updated systematic review relevant studies...
Recent trials suggest procalcitonin-based guidelines can reduce antibiotic use for respiratory infections. However, the accuracy of procalcitonin to discriminate between viral and bacterial pneumonia requires further dissection. We evaluated association serum concentration at hospital admission with pathogens detected in a multicenter prospective surveillance study adults hospitalized community-acquired pneumonia. Systematic pathogen testing included cultures, serology, urine antigen tests,...
A disruption of the crosstalk between gut and lung has been implicated as a driver severity during respiratory-related diseases. Lung injury causes systemic inflammation, which disrupts barrier integrity, increasing permeability to microbes their products. This exacerbates resulting in positive feedback. We aimed test whether severe Coronavirus disease 2019 (COVID-19) is associated with markers disrupted permeability. applied multi-omic systems biology approach analyze plasma samples from...
New evidence is available examining the use of corticosteroids in sepsis, acute respiratory distress syndrome (ARDS) and community-acquired pneumonia (CAP), warranting a focused update 2017 guideline on critical illness-related corticosteroid insufficiency.
Objective To evaluate the safety and efficacy of E5, a murine, monoclonal antibody directed against endotoxin, in treatment patients with Gram-negative sepsis. Design A multicenter, randomized, double-blind, placebo-controlled trial. Setting Fifty-three hospitals across United States, including university medical centers, Veterans Affairs Medical Centers, community hospitals. Patients 847 were randomized into this study. Enrolled met criteria for three conditions: a) known or suspected...
In patients with the acute respiratory distress syndrome, pneumothorax and other air leaks — any extrusion of outside tracheobronchial tree have been attributed to high ventilatory pressures or volumes linked increased mortality.
Prevalence of Staphylococcus aureus community-acquired pneumonia (CAP) and its clinical features remain incompletely understood, complicating empirical selection antibiotics.Using a multicenter, prospective surveillance study adults hospitalized with CAP, we calculated the prevalence methicillin-resistant S. (MRSA) methicillin-susceptible (MSSA) among all CAP episodes. We compared epidemiologic, radiographic, characteristics (per respiratory or blood culture) those pneumococcal culture urine...