A5100633885- Ginseng Biological Effects and Applications
- Food composition and properties
- Wheat and Barley Genetics and Pathology
- Medicinal Plants and Bioactive Compounds
- Retinal Diseases and Treatments
- Crop Yield and Soil Fertility
- Blood Pressure and Hypertension Studies
- Fungal Biology and Applications
- Metabolomics and Mass Spectrometry Studies
- Glaucoma and retinal disorders
- Traditional Chinese Medicine Studies
- Genetics and Plant Breeding
- Pharmacological Effects of Natural Compounds
- Food Quality and Safety Studies
- Phytochemicals and Antioxidant Activities
- Tryptophan and brain disorders
- Hormonal Regulation and Hypertension
- Natural Antidiabetic Agents Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nitric Oxide and Endothelin Effects
- Plant Disease Resistance and Genetics
- Polysaccharides Composition and Applications
- Cardiovascular Health and Disease Prevention
- Antioxidants, Aging, Portulaca oleracea
- Sexual function and dysfunction studies
Jiaxing University
2025
Chinese People's Liberation Army
2024
Tianjin Medical University
2015-2024
Tianjin Medical University Eye Hospital
2015-2024
Peking University First Hospital
2019-2024
Peking University
2013-2024
Jiangsu Academy of Agricultural Sciences
2024
Shanxi Medical University
2024
SihuanPharm (China)
2024
Nanjing Forestry University
2023
The renin-angiotensin system (RAS) plays a critical role in the development of diabetic nephropathy, and blockade RAS is currently used for treatment nephropathy. One major problem current inhibitors compensatory renin increase, which reduces efficacy inhibition. We have shown that vitamin D exerts renoprotective actions by transcriptionally suppressing renin. Here we demonstrated combination therapy with an AT1 receptor blocker analog markedly ameliorated renal injury streptozotocin...
The prognosis of patients with ovarian cancer has remained poor mainly because aggressive progression. Since epithelial-mesenchymal transition (EMT) is an important mechanism mediating invasion and metastasis cells, targeting the EMT process more efficacious less toxic compounds to inhibit great therapeutic value for treatment cancer. We have found first time that ginsenoside 20(S)-Rg3, a pharmacologically active component traditional Chinese herb Panax ginseng, potently blocks...
Arrhythmogenic cardiomyopathy (AC) shows large heterogeneity in its clinical, genetic, and pathological presentation. This study aims to provide a comprehensive atlas of end-stage AC illustrate the relationships among clinical characteristics, genotype, profiles patients with this disease.We collected 60 explanted hearts performed standard pathology examinations. The characteristics patients, their genotype cardiac magnetic resonance imaging findings were assessed along characteristics....
Ginseng, the roots and rhizomes of Panax ginseng C. A. Meyer, is used not only as a herbal medicine but also functional food to support body functions. Ginsenoside Rg3 (GRg3) major bioactive component in ginseng. In this study, beneficial effects GRg3 on rats with Alzheimer's disease (AD) were evaluated via behavioral experiment antioxidant capacity. Moreover, metabolomic analysis based UPLC-QTOF-MS/MS apoptosis was obtain change between AD GRg3-administrated assess underlying mechanisms...
Ganoderic acid A (GAA) is a kind of lanostane-type triterpenoid isolated from Ganoderma lucidum. Imbalance the Th17/Tregs axis exists in progress neuroinflammation Alzheimer's disease (AD). In this study, alleviating neuroinflammatory effect GAA on d-galactose mice was studied aspect regulating imbalance axis. The Morris water maze test used to evaluate cognitive ability AD mice. Flow cytometry detect percentages IL-17A, IL-17F, IL-21, IL-22, and CD4+CD25+Foxp3+ peripheral blood....
Ganoderma lucidum (G. lucidum) polysaccharide-1 (GLP-1) is one of the polysaccharides isolated from fruiting bodies G. lucidum. Inflammation in brain-liver axis plays a vital role progress cognitive impairment. In this study, beneficial effect GLP-1 on d-galactose (d-gal) rats was carried out by regulating inflammation axis. A Morris water maze test used to assess ability d-gal rats. ELISA and/or western blot analysis were detect blood ammonia and inflammatory cytokines levels Metabolomic...
Abstract Background Type 2 diabetes mellitus (T2DM), characterized by β-cell dysfunction and insulin resistance (IR), presents considerable treatment challenges. Apelin is an adipocyte-derived factor that shows promise in improving IR; however, it limited poor targeting a short half-life. In the present study, engineered small extracellular vesicles (sEVs) derived from Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) loaded with apelin were used to address limitations of therapeutic...
Abstract Dry eye is a highly prevalent, chronic and multifactorial disease that compromises quality of life generates socioeconomic burdens. The pathogenic factors dry (DED) include tear secretion abnormalities, film instability ocular surface inflammation. An effective intervention targeting the needed to control this disease. Here we applied α-Melanocyte-stimulating hormone (α-MSH) twice day scopolamine-induced rat model. results showed α-MSH at different doses ameliorated secretion,...
To detect and analyze the changes on ocular surface tear function in type II diabetic patients with proliferative retinopathy (PDR), an advanced stage of (DR), using conventional ophthalmic tests high-resolution laser scanning confocal microscopy.Fifty-eight diabetes were selected. Based diagnostic criteria classification DR, divided into non-DR (NDR) group PDR group. Thirty-six cataract but no other systemic disease included as non-diabetic controls. All subjected to clinical corneal...
Blood-retinal barrier (BRB) breakdown and vascular leakage is the leading cause of blindness diabetic retinopathy (DR). Hyperglycemia-induced oxidative stress inflammation are primary pathogenic factors this severe DR complication. An effective interventional modality against during early needed to curb BRB leakage. This study sought examine protective effects α-Melanocyte-stimulating hormone (α-MSH) on retina hyperpermeability, electrophysiological dysfunction, morphological deterioration...
Background: Total flavonoids of Rhizoma Drynariae (TFRD), extracted from the kidney-tonifying traditional Chinese medicine Rrynariae, has been proved to be effective in treating osteoporosis, bone fractures and defects. However, pharmacological effects TFRD on type H vessels, angiogenic-osteogenic coupling distraction osteogenesis (DO) mechanism remain unclear. This study aims at investigating whether vessels exist DO model, further elucidating underlying mechanism. Methods: Rats models...
Gentianae Radix et Rhizoma is a medical plant that widely cultivated in China, North Korea, Japan, and Russia, gentiopicroside one of its major active compounds. In this study, the hepatoprotective activity on rats with alcoholic liver damage (ALD) was evaluated using transaminase blood lipid levels antioxidant capacity. The potential mechanism effect by mitochondrial function detection, gas chromatography–mass spectrometry (GC–MS) metabolomic analysis, anti‐apoptosis analysis. Results...