A5100718748- Gastric Cancer Management and Outcomes
- Reconstructive Surgery and Microvascular Techniques
- Acupuncture Treatment Research Studies
- Osteoarthritis Treatment and Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Lower Extremity Biomechanics and Pathologies
- Organ and Tissue Transplantation Research
- Tuberculosis Research and Epidemiology
- Total Knee Arthroplasty Outcomes
- Phase Equilibria and Thermodynamics
- Music Therapy and Health
- Metastasis and carcinoma case studies
- Musculoskeletal pain and rehabilitation
- Healthcare and Venom Research
- Anesthesia and Pain Management
- Fungal Infections and Studies
- HIV/AIDS drug development and treatment
- Orthopedic Surgery and Rehabilitation
- Intensive Care Unit Cognitive Disorders
- Gastrointestinal Tumor Research and Treatment
- Spine and Intervertebral Disc Pathology
- Myofascial pain diagnosis and treatment
- Autoimmune and Inflammatory Disorders Research
- Protein Degradation and Inhibitors
- Environmental DNA in Biodiversity Studies
Sichuan University
2021-2025
State Key Laboratory of Biotherapy
2021-2025
China University of Petroleum, East China
2022-2024
Infinitus (China)
2018-2024
Chinese PLA General Hospital
2024
West China Hospital of Sichuan University
2021-2024
Yale University
2024
Zhuzhou Central Hospital
2023-2024
Shanghai Ocean University
2023
Swinburne University of Technology
2023
ABSTRACT The major cause of athlete’s foot is Trichophyton rubrum , a dermatophyte or fungal pathogen human skin. To facilitate molecular analyses the dermatophytes, we sequenced T. and four related species, tonsurans equinum Microsporum canis gypseum . These species differ in host range, mating, disease progression. genomes are highly colinear yet contain gene family expansions not found other human-associated fungi. Dermatophyte enriched for families containing LysM domain, which binds...
Abstract Pneumocystis jirovecii is a major cause of life-threatening pneumonia in immunosuppressed patients including transplant recipients and those with HIV/AIDS, yet surprisingly little known about the biology this fungal pathogen. Here we report near complete genome assemblies for three species that infect humans, rats mice. genomes are highly compact relative to other fungi, substantial reductions ribosomal RNA genes, transporters, transcription factors many metabolic pathways, but...
Three closely related thermally dimorphic pathogens are causal agents of major fungal diseases affecting humans in the Americas: blastomycosis, histoplasmosis and paracoccidioidomycosis. Here we report genome sequence analysis four strains etiological agent Blastomyces, two species genus Emmonsia, typically small mammals. Compared to species, Blastomyces genomes highly expanded, with long, often sharply demarcated tracts low GC-content sequence. These GC-poor isochore-like regions enriched...
Abstract Black or dark brown (phaeoid) fungi cause cutaneous, subcutaneous, and systemic infections in humans. thrive stressful conditions such as intense light, high radiation, very low pH. Wangiella (Exophiala) dermatitidis is arguably the most studied phaeoid fungal pathogen of Here, we report our comparative analysis genome W. transcriptional response to pH stress. This revealed that has lost ability synthesize alpha-glucan, a cell wall compound many pathogenic use evade host immune...
Hyperactivation of the mechanistic target rapamycin (mTOR) kinase, as a result loss-of-function mutations in tuberous sclerosis complex 1 (<i>TSC1</i>) or <i>TSC2</i> genes, causes protein synthesis dysregulation, increased cell size, and aberrant neuronal connectivity. Dysregulated synaptic proteins has been implicated pathophysiology autism spectrum disorder (ASD) associated with TSC fragile X syndrome. However, type-specific translational profiles these disease models remain to be...
Polylactic glycolic acid copolymer (PLGA) has been widely used in tissue engineering due to its good biocompatibility and degradation properties. However, the mismatched mechanical unsatisfactory biological properties of PLGA limit further application bone engineering. Calcium sulfate (CaSO4) is one most promising repair materials non-immunogenicity, well biocompatibility, excellent conductivity. In this study, aiming at shortcomings activity-lack low engineering, customized-designed 3D...
Background: Total flavonoids of Rhizoma Drynariae (TFRD), extracted from the kidney-tonifying traditional Chinese medicine Rrynariae, has been proved to be effective in treating osteoporosis, bone fractures and defects. However, pharmacological effects TFRD on type H vessels, angiogenic-osteogenic coupling distraction osteogenesis (DO) mechanism remain unclear. This study aims at investigating whether vessels exist DO model, further elucidating underlying mechanism. Methods: Rats models...
Objective. Impaired static stability and proprioception have been observed in individuals with knee osteoarthritis (KOA), which serves as a major factor increasing risk of fall. This study aimed to investigate the effects backward walking (BW) on stability, proprioception, pain, physical function KOA patients. Methods. Thirty-two subjects were randomly assigned either an BW group (BG, n = 16) or control (CG, 16). The participants BG received combination treatment 4-week training conventional...
Background: The pathological mechanism of knee osteoarthritis (KOA) is unknown. KOA degeneration may be associated with changes in muscle strength, proprioception, biomechanics, and postural stability. Objective: This study aimed to assess asymmetries stability bilateral lower limbs patients unilateral healthy controls analyze correlations between these parameters. Methods: A total 50 (age range: 50-70) subjects were recruited as participants 50-70). Muscle femorotibial angle (FTA), femoral...
Background: Clinical incidences of chronic low back pain among the elderly are increasing. However, studies have not fully elucidated on changes in biomechanical properties paravertebral muscles patients with unilateral pain. We evaluated painful and non-painful Methods: Biomechanical muscles, including muscle tone stiffness, were measured using MyotonPRO. Lumbar Lordosis Sacral Slope by magnetic resonance imaging. Cross-sectional areas ImageJ software version 1.53. Chronic severity was...
In gastric cancer, the relationship between human epidermal growth factor receptor 2 (HER2), cyclic GMP-AMP synthase—stimulator of interferon genes (cGAS-STING) pathway, and autophagy remains unclear. This study examines whether HER2 regulates in cancer cells via cGAS-STING signaling influencing key processes such as cell proliferation migration. Understanding this could uncover new molecular targets for diagnosis treatment. Through lentiviral transfection, counting kit-8 assays, colony...