A5100434261- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Drug Transport and Resistance Mechanisms
- Orthopaedic implants and arthroplasty
- Cancer Treatment and Pharmacology
- Natural product bioactivities and synthesis
- Bone fractures and treatments
- RNA modifications and cancer
- Total Knee Arthroplasty Outcomes
- Nanoparticle-Based Drug Delivery
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Orthopedic Infections and Treatments
- Adipose Tissue and Metabolism
- Hepatitis C virus research
- Orthopedic Surgery and Rehabilitation
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Hepatitis B Virus Studies
- Colorectal Cancer Treatments and Studies
Shanghai Ninth People's Hospital
2015-2025
Shanghai Jiao Tong University
2019-2025
China Pharmaceutical University
2016-2025
Zhongnan Hospital of Wuhan University
2012-2025
Wuhan University
2013-2025
Chengdu Second People's Hospital
2021-2025
Northwest University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
National Center for Drug Screening
2025
University of Chinese Academy of Sciences
2020-2025
Purpose To quantitatively map cerebral metabolic rate of oxygen ( ) and extraction fraction in human brains using quantitative susceptibility mapping (QSM) arterial spin labeling‐measured blood flow (CBF) before after caffeine vasoconstriction. Methods Using the multiecho, three‐dimensional gradient echo sequence an oral bolus 200 mg caffeine, whole brain were mapped at 3‐mm isotropic resolution on 13 healthy subjects. The QSM‐based was compared with ‐based to analyze regional consistency...
Abstract Purpose Circular RNA (circRNA) has emerged as a promising therapeutic molecule due to its enhanced stability and prolonged protein expression compared messenger (mRNA). Using circRNA construct transient Chimeric Antigen Receptor (CAR)-T cells can mitigate the limitations of conventional viral vector-based CAR-T approaches, such complex process long-term side effects. Methods The study first reconfirmed advantageous properties circRNA, focusing on efficiency. Electroporation...
Objective: The primary objective of this study is to develop and validate a high-risk model for Arteriovenous Fistula Thrombosis (AVFT) in patients undergoing autogenous arteriovenous fistula surgery hemodialysis. Methods: Retrospectively, we collected general information, clinical characteristics, laboratory examinations, dialysis-related factors from cohort 1465 who received continuous at the Hemodialysis Access Center Sichuan Provincial People’s Hospital between January 2019 June 2022....
P-glycoprotein (P-gp) is an ATP-dependent efflux transporter highly expressed in gastrointestinal tract and multidrug resistance tumor cells. Inhibition or induction of P-gp can cause drug-drug interactions thus influence the effects substrate drugs. Previous studies indicated that 20(<i>S</i>)-ginsenoside Rh2 [20(<i>S</i>)-Rh2] could synergistically enhance anticancer conventional chemotherapeutic agents at a nontoxic dose. The aim present study was to investigate vitro vivo whether...
Intracellular pharmacokinetics of anticancer drugs in multi-drug resistance (MDR) cancer cells is hugely important the evaluation and improvement drug efficacy. By using adriamycin as a probe MDR cells, we developed cellular pharmacokinetic-pharmacodynamic (PK-PD) model to reveal correlation between pharmacokinetic properties resistance. In addition, ability 20(S)-ginsenoside Rh2 (20(S)-Rh2) reverse was further investigated.The were analysed visually quantitatively human breast MCF-7...
Abstract Adriamycin (ADR) induces the over-expression of P-glycoprotein (P-gp) and multiple drug resistance in breast cancer cells. However, biochemical process underlying mechanisms are not clear. Our previous study revealed that ADR increased reactive oxygen species (ROS) generation decreased glutathione (GSH) biosynthesis, while N-acetylcysteine, ROS scavenger, reversed P-gp. The present showed inhibited influx cystine (the source material GSH) activity SLC7A11 transporter (in charge...
Purpose We assessed the accuracy of quantitative susceptibility mapping in a gadolinium balloon phantom with large range values and imaging resolutions at 1.5 3 Tesla (T). Theory Methods The contained sources 0.4, 0.8, 1.6, 3.2 ppm was imaged isotropic 0.7, 1.2, 1.8 mm. Numerical simulations were performed to match experimental findings. Voxel sensitivity effects used explain underestimations. Results Both data simulation demonstrated that systematic underestimation increased voxel size,...
Abstract Breast cancer is one of the most threatening diseases for women. Long noncoding RNAs were reported to be involved in breast development. In this study, we analyzed The Cancer Genome Atlas tissue high‐throughput sequencing data and screened validated low‐expressing long RNA named MAGI2‐AS3. Through gene coexpression analysis, found that MAGI2‐AS3 has a good expression correlation with MAGI2. Overexpression or MAGI2 cells MCF‐7 would inhibit Wnt/β‐catenin pathway cell proliferation...
Abstract Background Despite receiving orthokeratology (ortho-k), the efficacy of retarding ocular elongation during myopia varies among myopic children. The current study aimed to investigate early changes choroidal vasculature at one month after ortho-k treatment and its association with one-year elongation, as well role such responses in predicting control treatment. Methods A prospective cohort was conducted children treated ortho-k. Myopic aged between 8 12 years who were willing wear...
Abstract Patients with inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, often suffer drug intolerance. This resistance can be divided into intrinsic acquired resistance. Although there is agreement on resistance, studies regarding have demonstrated inconsistencies, especially for disease. For this reason, an animal model of was induced 2,4,6-trinitrobenzene sulfonic acid solution (TNBS) analyzed by measuring the function expression P-glycoprotein (P-gp) in...
// Guanghui Hu 1 * , Binbin Dong 2, Jingwei Zhang 1, Wei Zhai 3 Tiancheng Xie Bisheng Huang Chi 4 Xudong Yao Junhua Zheng Jianping Che and Yun-Fei Xu Department of Urology, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China 2 Yancheng Third Yancheng, Jiangsu, Renji Jiaotong Nanjing Medical Nanjing, These authors have contributed equally to this work Correspondence to: Xu, email: xuyunfeibb@sina.com Che, chejianping77@126.com Zhai, jacky_zw2002@hotmail.com Keywords:...
Shenmai injection (SMI) is a well-defined herbal preparation that widely and clinically used as an adjuvant therapy for cancer. Previously, we found SMI synergistically enhanced the activity of chemotherapy on colorectal cancer by promoting distribution drugs in xenograft tumors. However, underlying mechanisms bioactive constituents remained unknown. In present work, regulatory effects tumor vasculature were determined, potential anti-angiogenic components targeting endothelial cells (TECs)...
Vascular abnormality is a hallmark of most solid tumors and facilitates immune evasion. Targeting the abnormal metabolism tumor endothelial cells (TECs) may provide an opportunity to improve outcome immunotherapy. Here, in comparison vascular from adjacent peritumoral tissues patients with colorectal cancer (CRC), TECs presented enhanced glycolysis higher glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression. Then unbiased screening identified that osimertinib could modify GAPDH thus...
Background Phytochemical-mediated alterations in P-glycoprotein (P-gp) activity may result herb-drug interactions by altering drug pharmacokinetics. Shengmai-san, a traditional Chinese herbal medicine composed Panax Ginseng, Ophiopogon Japonicus, and Schisandra Chinensis, is routinely being used for treating various coronary heart diseases. In our previous studies, Lignans Extract (SLE) was proved as strong P-gp inhibitor, herein, the compatibility of Shengmai-san studied investigating...