A5100603586- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Metabolomics and Mass Spectrometry Studies
- Chromatography in Natural Products
- Tryptophan and brain disorders
- Cardiac Valve Diseases and Treatments
- Gut microbiota and health
- Pharmacogenetics and Drug Metabolism
- Analytical Chemistry and Chromatography
- Drug-Induced Hepatotoxicity and Protection
- Aortic Disease and Treatment Approaches
- Phytochemistry and Biological Activities
- Congenital Heart Disease Studies
- Synthesis and biological activity
- Atrial Fibrillation Management and Outcomes
- Plant Pathogens and Resistance
- Phytochemistry and biological activity of medicinal plants
- Sepsis Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- Bioactive Natural Diterpenoids Research
- Crystal structures of chemical compounds
- Potato Plant Research
- Respiratory viral infections research
Nanjing University of Chinese Medicine
2016-2025
Northeast Agricultural University
2025
West China Medical Center of Sichuan University
2023-2025
Yancheng Institute of Technology
2024-2025
Hebei General Hospital
2023-2025
Shanghai Children's Medical Center
2013-2024
Gansu Agricultural University
2022-2024
Shandong First Medical University
2021-2024
Shanghai Jiao Tong University
2018-2024
University of Missouri Health System
2024
Ginsenoside Rg3 (Rg3), a major active ingredient enriched in red ginseng, possesses well-confirmed immunoregulatory effects. Immune disturbance is common trigger and aggravating factor of depression. The aim this study was to explore the effects on lipopolysaccharide (LPS)-induced depression-like behavior mice involvement immune regulation. Pretreatment with (i.g., 20 40 mg/kg) effectively ameliorated LPS (i.p., 0.83 induced body weight loss, anorexia, immobility time both tail suspension...
The dopamine, serotonin, and kynurenine metabolic pathways play pivotal roles on brain function, their disturbances are closely related to various neurological diseases. Comprehensive measurements of these metabolites is thus essential for monitoring the global neurochemical responses pathological challenges or drug intervention. However, simultaneous measurement neurochemcial represents a great challenge. We developed herein an original feasible method using high-performance liquid...
Abstract Background The effectiveness of ginseng in preventing and treating various central nervous system (CNS) diseases has been widely confirmed. However, ginsenosides, the principal components ginseng, are characterized by poor accessibility to brain, this pharmacokinetic-pharmacological paradox remains poorly explained. Anti-inflammatory approaches becoming promising therapeutic strategies for depression other CNS diseases; however, previous studies have focused largely on...
Rhein is one of active anthraquinone components in traditional Chinese herbal medicine Rheum palmatum L., possessing anti-inflammatory, antioxidant, antitumor, antiviral, and hepatoprotective activities. Human respiratory syncytial virus (RSV), a common virus, able to result pneumonia bronchitis, which usually can be seen infants. However, so far the effects on RSV-induced are still unknown. As NLRP3 inflammasome activated excessively, it lead inflammatory response tissue injury most viral...
Irinotecan (CPT-11)-induced gastrointestinal toxicity strongly limits its anticancer efficacy. Glycyrrhiza uralensis Fisch., especially flavonoids, has strong anti-inflammatory and immunomodulatory activities. Herein, we investigate the protective effect of total flavonoids G. (TFGU) on CPT-11–induced colitis mice from perspective gut microbiota fecal metabolism. The body weight colon length were measured. Our results showed that oral administration TFGU significantly attenuated loss...
Background Depression and the increased risk of sarcopenia are prevalent among elderly population. However, causal associations between these factors remain unclear. To investigate potential association depression in older adults, this study was performed. Methods In baseline survey, a total 14,258 individuals aged 40 above from China Health Retirement Longitudinal Study (2015) participated. We initially described prevalence disease. Then, logistic regression restricted cubic spline (RCS)...
As a well-known traditional Chinese medicine (TCM) prescription, Xin-Sheng-Hua Granule (XSHG) has been applied in China for more than thirty years to treat postpartum diseases, especially anaemia. However, the underlying therapeutic mechanisms of XSHG anaemia were still unclear. In this study, plasma metabolomics profiling was firstly analyzed by UHPLC-QTOF/MS and multivariate data method. Using network pharmacology, compound-target-pathway constructed, so as dissect anaemia-relevant...
The pharmacokinetic properties of RA were characterized as rapid absorption, middle-speed elimination, poor absolute bioavailability, and lack dose proportionality.
BACKGROUND Laryngeal cancer is a malignant head and neck tumor with high morbidity mortality in humans. Recently, treatments Chinese medicines their extracts have gradually received great attention, studies suggest that Boschniakia rossica polysaccharide (BRP) has potential anti-tumor activity. Therefore, this study investigating the role of BRP inducing apoptosis human laryngeal carcinoma cells. MATERIAL AND METHODS The was extracted organic solvent HR column. We treated Hep2 cells...
The Zushima tablet (ZT) has been used for decades in the clinical treatment of rheumatoid arthritis (RA) China. However, its therapeutic mechanism is unclear. In this study, we aimed to explore distinctive metabolic patterns collagen-induced (CIA) rats and evaluate effects ZT on RA using untargeted serum fecal metabolomics approaches based gas chromatography coupled with mass spectrometry. Body weight, hind paw swelling, TNF-α IL-1β levels, scores, histopathological parameters were assessed....
Abstract The involvement of systemic immunity in depression pathogenesis promises a periphery-targeting paradigm novel anti-depressant discovery. However, relatively little is known about druggable targets the periphery for mental and behavioral control. Here we report that targeting Ly6C hi monocytes blood can serve as strategy purpose. A natural compound, ginsenoside Rg1 (Rg1), was firstly validated periphery-restricted chemical probe. selectively suppressed recruitment to inflamed mice...
Abstract Patients with inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, often suffer drug intolerance. This resistance can be divided into intrinsic acquired resistance. Although there is agreement on resistance, studies regarding have demonstrated inconsistencies, especially for disease. For this reason, an animal model of was induced 2,4,6-trinitrobenzene sulfonic acid solution (TNBS) analyzed by measuring the function expression P-glycoprotein (P-gp) in...