A5100661481- Influenza Virus Research Studies
- Respiratory viral infections research
- COVID-19 epidemiological studies
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Pediatric health and respiratory diseases
- Viral Infections and Outbreaks Research
- Viral gastroenteritis research and epidemiology
- interferon and immune responses
- Chronic Obstructive Pulmonary Disease (COPD) Research
- T-cell and B-cell Immunology
- COVID-19 and healthcare impacts
- Inflammasome and immune disorders
- Respiratory Support and Mechanisms
- Climate Change and Health Impacts
- COVID-19 Pandemic Impacts
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Animal Disease Management and Epidemiology
- Long-Term Effects of COVID-19
- Allergic Rhinitis and Sensitization
- SARS-CoV-2 detection and testing
- Neonatal Respiratory Health Research
Jiangsu Provincial Center for Disease Control and Prevention
2016-2025
Nanjing University of Chinese Medicine
2016-2025
Nanjing Health and Health Commission
2023
First Affiliated Hospital of Guangdong Pharmaceutical University
2023
Chinese Academy of Sciences
2019
Sichuan Center for Disease Control and Prevention
2019
Henan Provincial Center for Disease Control and Prevention
2019
Mayo Clinic
2019
Jiangsu Province Hospital
2019
National Institute for Viral Disease Control and Prevention
2019
Exhausted-like CD8 + resident memory T cells in the lung limit immune activation–driven fibrosis.
Rhein is one of active anthraquinone components in traditional Chinese herbal medicine Rheum palmatum L., possessing anti-inflammatory, antioxidant, antitumor, antiviral, and hepatoprotective activities. Human respiratory syncytial virus (RSV), a common virus, able to result pneumonia bronchitis, which usually can be seen infants. However, so far the effects on RSV-induced are still unknown. As NLRP3 inflammasome activated excessively, it lead inflammatory response tissue injury most viral...
To determine the seroprevalence and seroconversion of avian influenza virus (AIV) antibodies in poultry workers, we conducted a seroepidemiologic study 7 areas China during December 2014-April 2016. We used viral isolation reverse transcription PCR to detect AIVs specimens from live markets. analyzed 2,124 serum samples obtained 1,407 workers by using hemagglutination inhibition microneutralization assays. noted AIV for subtypes H9N2, H7N9, H6N1, H5N1-SC29, H5N6, H5N1-SH199, H6N6. In...
Severe fever with thrombocytopenia syndrome (SFTS) was listed as one of the most severe infectious disease by world health organization in 2017. It can mostly be transmitted tick bite, while human-to-human transmission has occurred on multiple occasions. This study aimed to explore epidemiological and clinical characteristics make risk analysis SFTS transmission.Descriptive spatial methods were employed illustrate transmission. The accessed through secondary attack rate (SAR) basic...
Influenza virus causes a heterogeneous respiratory infectious disease ranging from self-limiting symptoms to non-resolving pathology in the lungs. Worldwide, seasonal influenza infections claim ~500,000 lives annually. Recent reports describe pathologic pulmonary sequelae that result remodeling architecture of lung parenchyma following infections. These dysfunctional recovery processes disproportionately impact elderly have been understudied. Macrophages are involved tissue and critical for...
ABSTRACT Background and objective Asthma is a global problem complex disease suited for metabolomic profiling. This study explored the candidate biomarkers specific to paediatric asthma provided insights into asthmatic pathophysiology. Methods Children (aged 6–11 years) meeting criteria healthy control ( n = 29), uncontrolled 37) or controlled 43) were enrolled. Gas chromatography–mass spectrometry was performed on urine samples of patients explore different types metabolite profile in...
Tissue resident memory CD8 T cells (TRM) serve as potent local sentinels limited to previous sites of inflammation and their draining lymph nodes. TRM contribute significantly protective immunity against previously encountered intracellular mucosal pathogens. While the molecular transcriptional underpinnings differentiation are emerging, how establishment is regulated at cellular level by other immune cell types in vivo largely unclear. Here, we observed that expression PPAR-γ myeloid...
Since first identified in 2013, the H7N9 virus has caused several waves of human infections China, with a current wave including number patients very severe disease. Jiangsu is one most impacted provinces, whereby as 31 January 2017, (n = 109) ongoing fifth exceeded sum those four preceding ones. Ten 13 cities have been affected, and clustered well co-infection seasonal influenza observed. With median age 58 years 74.3% (81/109) being male, characteristics cases are similar to previous...
BACKGROUND:Bronchial asthma is a common pediatric disease, the pathogenesis of which complicated. The correlations levels inflammatory factors in peripheral serum with intestinal flora and gastrointestinal incommensurate symptoms children remain to be further elucidated. MATERIAL AND METHODS:A total 70 diagnosed Pediatric Department our hospital from February 2016 March 2017 were enrolled as an observation group, another 25 healthy same age range selected control group. [C-reactive protein...
Background Non-pharmaceutical interventions (NPIs) during the COVID-19 pandemic altered influenza transmission patterns, yet age-specific effects of air pollutants on dynamics remain unclear. Methods Utilizing surveillance data Jiangsu Province from 2020 to 2024, we integrated generalized additive quasi-Poisson regression model and distributed lag non-linear models (DLNM) quantify lagged exposure-response relationships between (NO 2 , SO PM 2.5 ) risk across young, middle-aged, older adult...
We investigated an outbreak of COVID-19 infection, which was traced back to a bathing pool at entertainment venue, explore the epidemiology outbreak, understand transmissibility virus and analyse influencing factors. Contact investigation management were conducted identify potential cases. Epidemiological carried out determine epidemiological demographic characteristics outbreak. estimated secondary attack rate (SAR), incubation time time-dependent reproductive number (Rt) explored...
Abstract Allergic rhinitis (AR) is one of the most common allergic diseases in children and it can lead to physical mental health problems. Traditional Chinese medicine (TCM) plays an important role understanding phenotypes treatment AR. However, there are currently no normative clinical practice guidelines (CPGs) for AR children. The study aimed develop evidence‐based CPG with TCM. Systematic literature research, expert questionnaire, evaluation after three rounds surveys were adopted form...
H7N9 continues to cause human infections and remains a pandemic concern. Understanding the economic impacts of this novel disease is important for making decisions on health resource allocation, including infectious prevention control investment. However, there are limited data such impacts.Hospitalized laboratory-confirmed patients or their families in Jiangsu Province China were interviewed. Patients' direct medical costs hospitalization derived from hospital bills. A generalized linear...
Live poultry markets (LPMs) are crucial places for human infection of influenza A (H7N9 virus).In Yangtze River Delta, LPMs were closed after the outbreak with avian (H7N9) virus, and then reopened when no case was found.Our purpose to quantify effect LPMs' operations in this region on transmission virus.We obtained information about dates symptom onset locations all cases reported from Shanghai, Jiangsu Zhejiang provinces by May 31, 2014, acquired closures reopening official media.A...
Influenza activity is subject to environmental factors. Accurate forecasting of influenza epidemics would permit timely and effective implementation public health interventions, but it remains challenging. In this study, we aimed develop random forest (RF) regression models including meterological factors predict seasonal in Jiangsu provine, China. Coefficient determination (R2) mean absolute percentage error (MAPE) were employed evaluate the models' performance. Three RF with optimum...
Background Four epidemic waves of human infection with H7N9 have been recorded in China up to 1 June 2016, including Jiangsu Province. However, few studies investigated the differences patients' characteristics among four waves, and analyses factors associated fatal lacked statistical power previous due limited sample size. Methods All laboratory‐confirmed A(H7N9) patients province were analysed. Patients' compared across between survivors those who died. Multivariate used identify...
Objectives Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineage B.1.617.2 (also named the Delta variant) was declared as a variant of concern by World Health Organization (WHO). This study aimed to describe outbreak that occurred in Nanjing city triggered through epidemiological parameters and understand evolving epidemiology variant. Methods We collected data all COVID-19 cases during from 20 July 2021 24 August estimated distribution serial interval, basic time-dependent...
Abstract Background Over the past 70 years, China has advanced significantly in prevention and treatment of infectious diseases while simultaneously undergoing a socioeconomic transformation, making it useful source data for analysing relationships between public health policy control diseases. Methods We collected on incidence notifiable associated fatalities Jiangsu province southeast from Provincial Center Disease Control Prevention, Institute Parasitic Diseases, Nationwide Notifiable...