A5050789312- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Pharmacological Effects of Natural Compounds
- Oral microbiology and periodontitis research
- Veterinary medicine and infectious diseases
- Infections and bacterial resistance
- Ginseng Biological Effects and Applications
- Animal Virus Infections Studies
- Essential Oils and Antimicrobial Activity
- Fungal Biology and Applications
- Animal Disease Management and Epidemiology
- Phytochemistry and biological activity of medicinal plants
- Electrochemical Analysis and Applications
- Phytochemistry and Bioactivity Studies
- Quinazolinone synthesis and applications
- Bioactive Compounds and Antitumor Agents
- Neonatal and Maternal Infections
- Virus-based gene therapy research
- Bacterial Genetics and Biotechnology
- Antibiotics Pharmacokinetics and Efficacy
- Berberine and alkaloids research
- Plant Pathogenic Bacteria Studies
- Natural Compounds in Disease Treatment
Northeast Agricultural University
2012-2025
Education Department of Heilongjiang Province
2019-2024
South China Agricultural University
2017
The 2030 Agenda for Sustainable Development envisions a rational use of energy and resources in all technological processes. However, the extraction methods compounds from medicinal plants herbs, there is an urgent to reduce organic solvents increase efficiency these methods. Therefore, sustainable method (enzyme ultrasonic co-assisted aqueous two-phase extraction, EUA-ATPE) simultaneous separation ferulic acid ligustilide Angelicae Sinensis Radix (ASR) was developed by integrating...
ABSTRACT Streptococcus suis ( S. ) has been increasingly recognized as a porcine zoonotic pathogen that threatens the health of both pigs and humans. Multidrug-resistant is becoming prevalent, novel strategies to treat bacterial infections caused by these organisms are desperately needed. In present study, an untargeted metabolomics analysis showed significant decrease in methionine content biosynthetic pathway were significantly affected Kyoto Encyclopedia Genes Genomes enrichment...
The emergence and rapid spread of methicillin-resistant Staphylococcus aureus (MRSA) raise a critical need for alternative therapeutic options. New antibacterial drugs targets are required to combat MRSA-associated infections. Based on this study, celastrol, natural product from the roots Tripterygium wilfordii Hook. f., effectively combats MRSA in vitro vivo. Multi-omics analysis suggests that molecular mechanism action celastrol may be related Δ
Due to the large amount of antibiotics used for human therapy, agriculture, and even aquaculture, emergence multidrug-resistant Streptococcus suis (S. suis) led serious public health threats. Antibiotic-assisted strategies have emerged as a promising approach alleviate this crisis. Here, polyphenolic compound gallic acid was found enhance sulfonamides against S. suis. Mechanistic analysis revealed that effectively disrupts integrity function cytoplasmic membrane by dissipating proton motive...
The aim of this study was to investigate the antimicrobial resistance profiles and genotypes Streptococcus suis in Heilongjiang Province, China. A total 29 S. were isolated from 332 samples collected 6 pig farms. results showed that serotypes 2, 4 9 prevalent, all clinical isolates resistant at least two antibacterial drugs. most resisted drugs macrolides, fluoroquinolones. Resistant genes ermB aph (3')-IIIa highly distributed among isolates, with detection rates 79.31% 75.86%. formation...
Antimicrobial resistance is recognized as one of the major global health challenges 21st century. Synergistic combinations for antimicrobial therapies can be a good strategy treatment multidrug resistant infections. We examined ability group 29 plant essential oils substances which enhance antibiotic activity. used modified well diffusion method to establish high-throughput screening easy and rapid identification high-level enhancement against bacteria. found that 25 possessed antibacterial...
This study aimed to extract glabridin (GLA) from licorice using an environmentally sustainable ultrasonic-assisted aqueous two-phase extraction method and evaluate its efficacy. The parameters were optimized through single-factor experiments response surface methodology, resulting in a GLA content of 2049.51 μg/g under the conditions 51 min ultrasonic time, 76 °C temperature, 640 W power. In vitro analyses demonstrated that (1.6 mg/mL) (8 μg/g) exhibited rapid bactericidal activity against...
Invasive infections due to Staphylococcus aureus, including methicillin-resistant S. aureus are prevalent and life-threatening. Combinations of antibiotic therapy have been employed in many clinical settings for improving therapeutic efficacy, reducing side effects drugs, development resistance. Pleuromutilins a potential be developed as new class antibiotics systemic use humans. In the current study, we investigated relationship between pleuromutilins, valnemulin, tiamulin, retapamulin, 13...
The emergence and rapid development of antibiotic resistance poses a serious threat to global public health. Streptococcus suis (S. suis) is an important zoonotic pathogen, the its has made infections difficult treat. combination non-antibiotic compounds with antibiotics considered promising strategy against multidrug-resistant bacteria. However, mechanism by which metabolites act as adjuvant remains unclear. Here, we found that guanosine metabolism was repressed in S. suis. Exogenous...
Staphylococcus xylosus (S. xylosus) is a type of coagulase-negative Staphylococcus, which was previously considered as non-pathogenic. However, recent studies have linked it with cases mastitis in cows. Isoliquiritigenin (ISL) bioactive compound pharmacological functions including antibacterial activity. In this study, we evaluated the effect ISL on S. vitro and vivo. The MIC against 80 μg/mL. It observed that sub-MICs (1/2MIC, 1/4MIC, 1/8MIC) significantly inhibited formation biofilm vitro....
Streptococcus suis is an important zoonotic pathogen. Due to the indiscriminate use of macrolides, S. has developed a high level drug resistance, which led serious threat human and animal health. However, it takes long time develop new antibacterial drugs. Therefore, we consider perspective bacterial physiological metabolism ensure that development resistance existing drugs alleviated susceptibility restored. In present study, untargeted metabolomics analysis showed serine catabolic pathway...
Streptococcus suis ( S. ) can decrease its virulence or modify local conditions through biofilm formation, which promotes infection persistence in vivo . Biofilm formation is an important cause of chronic drug-resistant infection. The aim this study was to evaluate whether tylosin effectively inhibits by interacting with O-acetylserine (thiol)-lyase B (CysM), a key enzymatic regulator cysteine synthesis. the mutant (ΔcysM) strain significantly lower compared wild-type ATCC 700794 strain....
The highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) poses a significant threat to the global swine industry. Vaccination is preventive measure against viral infections. However, use of vaccines in livestock healthcare programs faces challenge safety delayed immune responses. Earlier studies have shown potential modified Bazhen powder as an immunomodulator with biological properties, but its effect on HP-PRRSV yet be studied. This study elucidated how could...