A5102000976- Bioactive Natural Diterpenoids Research
- Traditional Chinese Medicine Analysis
- Metabolomics and Mass Spectrometry Studies
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Phytochemistry and Bioactive Compounds
- Cell death mechanisms and regulation
- Analytical Chemistry and Chromatography
- Ginger and Zingiberaceae research
- Chromatography in Natural Products
- Spectroscopy and Chemometric Analyses
- Drug-Induced Hepatotoxicity and Protection
- Biological Activity of Diterpenoids and Biflavonoids
- Food Quality and Safety Studies
- Phytochemicals and Antioxidant Activities
- Traditional Chinese Medicine Studies
- Advanced biosensing and bioanalysis techniques
- Medicinal Plants and Bioactive Compounds
- Cancer therapeutics and mechanisms
- Paraoxonase enzyme and polymorphisms
- Pancreatitis Pathology and Treatment
- Pesticide and Herbicide Environmental Studies
Sun Yat-sen University
2025
Third Affiliated Hospital of Sun Yat-sen University
2025
University of Oxford
2025
Nanjing University of Chinese Medicine
2015-2024
Shanghai Innovative Research Center of Traditional Chinese Medicine
2021
State Nuclear Power Technology Company (China)
2018
University of Washington
2014-2015
Nanjing University
2013
Southwest Jiaotong University
2011
Ministry of Education of the People's Republic of China
2007
Ligustri Lucidi Fructus (LLF), the fruit of Ligustrum lucidum Ait. (Oleaceae), has been used as a common herbal medicine in clinical practice China for nearly 2000 years. In most cases, LLF is prescribed decoctions form processed products rather than crude drugs. this study, an ultra-high performance liquid chromatography coupled with electrospray ionization-quadrupole-time flight-mass spectrometry (UHPLC-ESI-Q-TOF-MS) method was established rapid separation and identification multiple...
Glyphosate-based herbicides (GBH) are one of the most widely used pesticides worldwide. Industrial workers in glyphosate-based manufacture populations who experience long-term exposure to high glyphosate levels. The impacts on human health important public problem great concern. Up date, potential adverse effects humans or other mammals have been reported multiple studies. However, limited research is available lipid alternations related glyphosate. In fact, perturbations some metabolisms...
Untimely or improper treatment of traumatic bleeding may cause secondary injuries and even death. The traditional hemostatic modes can no longer meet requirements coping with complicated emergencies. With scientific technological advancements, a variety topical materials have been investigated involving inorganic, biological, polysaccharide, carbon-based materials. These their respective merits defects. In this work, the application mechanism major materials, especially some nanomaterials...
Diabetic nephropathy (DN) is the main cause of end-stage renal disease worldwide and a major public issue affecting health people. Therefore, it essential to explore effective drugs for treatment DN. In this study, traditional Chinese medicine (TCM) formula, Zhijun Tangshen Decoction (ZJTSD), prescription modified from classical formula Didang Decoction, has been used in clinical However, chemical basis underlying therapeutic effects ZJTSD treating DN remains unknown. compounds serum after...
Kansenone is a triterpene from the root of traditional Chinese medicine, Euphorbia kansui. However, kansenone exerts serious toxicity, but exact mechanism was not clear. In this work, effects on cell proliferation, cycle, damage, and apoptosis were investigated. The suppression proliferation assessed via colorimetric MTT assay, morphology visualized inverted microscopy after IEC-6 cells incubated with different concentrations kansenone. Reactive oxygen species (ROS), superoxide dismutase...
Oxidative stress, particularly ROS accumulation, plays a key role in the development of abdominal aortic aneurysm (AAA). Surgical treatments and current drugs for AAA have limitations, including lack specificity significant side effects. This study constructed ROS-responsive nanoparticles using phenylthio-modified dendritic polylysine (PDP) loaded with selenomethionine (PDPs-Se) treatment, elucidated its mechanism action. In-vitro studies revealed that PDPs-Se enhanced clearance by...
Euphorbia kansui stir-fried with vinegar (V-kansui) has promising biological activities toward treating malignant ascites reduced toxicity compared to crude kansui. But the mechanism concerning promoting excretion of not been systematically studied. The purpose this paper was investigate possible V-kansui in ascites, including metabolic pathways and molecular using an integrated serum urine metabolomics coupled network pharmacology. Serum samples rats were collected analyzed by...