A5100425702- Medical Research and Treatments
- Traditional Chinese Medicine Studies
- Plant-based Medicinal Research
- Phytochemistry and biological activity of medicinal plants
- Healthcare and Venom Research
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Complementary and Alternative Medicine Studies
- Pharmacovigilance and Adverse Drug Reactions
- Phytochemical and Pharmacological Studies
- Biological and pharmacological studies of plants
- Neurological Disease Mechanisms and Treatments
- Pharmacogenetics and Drug Metabolism
- Cancer Treatment and Pharmacology
- Metabolomics and Mass Spectrometry Studies
- Educational Reforms and Innovations
- Chromatography in Natural Products
- Phytochemistry and Biological Activities
- Lipid metabolism and disorders
- Nephrotoxicity and Medicinal Plants
- Academic integrity and plagiarism
- Bioactive Natural Diterpenoids Research
- Acupuncture Treatment Research Studies
- Career Development and Diversity
Chinese University of Hong Kong
2025
Chongqing Medical University
2014-2024
Shanghai University of Traditional Chinese Medicine
2023-2024
Beijing University of Chinese Medicine
2013-2024
Chinese PLA General Hospital
2010-2024
University of Veterinary and Animal Sciences
2024
Shanghai Institute for Science of Science
2023-2024
Central South University
2023-2024
Second Xiangya Hospital of Central South University
2023-2024
Shaanxi University of Chinese Medicine
2016-2024
Traditional Chinese Medicine (TCM) with its focus on herbal use became popular worldwide. Treatment was perceived as safe, neglect of rare adverse reactions including liver injury. To compile worldwide cases injury by TCM, we undertook a selective literature search in the PubMed database and searched for items Medicine, Asian Oriental also combined terms hepatotoxicity or herb induced The focused primarily English-language case reports, series, clinical reviews. We identified reported 77...
Linoleic acid (LA) not only functions as an essential nutrient, but also profoundly modulates oxidative stress and inflammatory response. However, the potential mechanisms have been adequately researched. Hence, this study examined pharmacological roles of LA underlying in mice with lipopolysaccharide (LPS)-associated acute liver injury (ALI). The results indicated that treatment alleviated histopathological abnormalities hepatic plasma levels aspartate aminotransferase (AST), alanine (ALT),...
2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG) from Polygoni multiflori has been demonstrated to possess a variety of pharmacological activities, including antioxidant, anti-inflammatory and hepatoprotective activities. Ultra-performance LC-quadrupole TOF-MS with MS Elevated Energy data collection technique rapid resolution LC diode array detection ESI multistage MS(n) methods were developed for the pharmacokinetics, tissue distribution, metabolism, excretion studies THSG in rats...
A global chemical profiling based quality evaluation approach using ultra performance liquid chromatography with tandem quadrupole time-of-flight mass spectrometry was developed for the of three rhubarb species, including Rheum palmatum L., tanguticum Maxim. ex Balf., and officinale Baill. Considering that comprehensive detection components is crucial profile, a systemic column method developed. Based on this, Cortecs used to acquire Chempattern software employed conduct similarity...
Since their discovery in 2004, there has been remarkable progress research on nanomotors starting with the elucidation of different propulsion mechanisms to study collective behavior, culminating investigations into applications biomedicine and environmental remediation. This perspective reviews this evolution discusses key challenges ahead, including development advanced characterization techniques, precise motion control, materials innovation, theory modelling, vivo applications. These not...
Objective: To explore the key role of fever clinics in prevention and control hospital-acquired infections. Methods: summarize implementation infectious disease reporting process, standardized operating procedures, infection monitoring system, disinfection isolation measures, medical waste management system a general hospital Zhangjiagang City, Jiangsu Province, since establishment outpatient clinic. Through retrospective analysis, study compared changes incidence infections, patient...
IgG4-related disease (IgG4-RD), an immune-mediated fibroinflammatory disorder, has few reports in combination with monoclonal gammopathy of undetermined significance (MGUS). Herein, we present a case 69-year-old woman manifestations left orbital occupation and visual acuity decline. Ancillary tests indicated persistent positivity IgG4 antibody, IgG4-RD-related ophthalmopathy was diagnosed based on the criteria. Concurrently, serum protein electrophoresis revealed M level 12.23 g/L....
An uncontrolled inflammation induced critical health problems with serious morbidity and death, which namely acute lung injury (ALI). Recently researchs have found the anti-inflammatory effects of emodin. Here, we investigated potential emodin on a mouse model lethal dose mechanisms lipopolysaccharide (LPS)-induced inflammatory in mice. The pulmonary histological abnormalities, Evans blue's leakage, myeloperoxidase (MPO) activity, grades TNF-α, IL-6, nitric oxide (NO), lactic acid (LA)...
Rhubarb is a common herb used in traditional Chinese medicine. However, few publications exist about its pharmacokinetic profiles animals or healthy volunteers. Whether retention enema administration of rhubarb extract affects pharmacokinetics as well tolerability unknown. Therefore, we set out to compare the parameters rhein administered by enemas with those conventional oral dosing extract. Eight male volunteers were enrolled prospective crossover study. All subjects received single dose...
We employed CE to identify mixtures of the toxic alkaloids lappaconitine, bullatine A, atropine sulfate, methobromide, scopolamine hydrobromide, anisodamine brucine, strychnine, quinine and chloroquine in human blood urine, using procaine hydrochloride as an internal standard. The separation a fused-silica capillary 75 microm id x 60 cm length (effective length: 50.2 cm) buffer containing 100 mM phosphate 5% ACN (pH 4.0). sample was injected pressure mode performed at voltage 16 kV...
Three new C19-norditerpenoid alkaloids (1–3), along with two known (4–5) have been isolated from Aconitum szechenyianum. Their structures were established by extensive spectroscopic techniques and chemical methods as szechenyianine A (1), B (2), C (3), N-deethyl-3-acetylaconitine (4), N-deethyldeoxyaconitine (5). Additionally, compounds 1–5 tested for the inhibition of NO production on LPS-activated RAW264.7 cells IC50 values 36.62 ± 6.86, 3.30 0.11, 7.46 0.89, 8.09 1.31, 11.73 1.94 μM,...
BACKGROUND This study aimed to investigate the inhibitory effect of blueberry anthocyanin (BBA) on Angiotensin II (Ang II)-induced apoptosis human umbilical vein endothelial cells (HUVECs), and its regulation mechanisms involving Bax Caspase 3. MATERIAL AND METHODS HUVECs were first treated by different concentrations Ang (10-9, 10-8, 10-7, 10-6, 10-5, 10-4 mol/L) BBA (80, 40, 20, 10, 5, 2.5 μg/ml). After 24 h 48 treatment, MTT was performed detect viability HUVECs. Then, randomly divided...
Aims Bruton's tyrosine kinase inhibitors (BTKIs), including first‐generation ibrutinib, second‐generation acalabrutinib and zanubrutinib, may be involved in the mechanisms of action related to adverse events (AEs) cardiovascular system. We aimed characterize AEs BTKIs reported US Food Drug Administration (FDA) Adverse Event Reporting System, compare risks BTKIs. Methods Across all indications three FDA‐approved BTKIs, primary suspect drugs were extracted over two periods: from January 2013...