A5006853238- Vagus Nerve Stimulation Research
- Nicotinic Acetylcholine Receptors Study
- Berberine and alkaloids research
- Inflammatory mediators and NSAID effects
- Receptor Mechanisms and Signaling
- NF-κB Signaling Pathways
- Alzheimer's disease research and treatments
- Drug Transport and Resistance Mechanisms
- Nitric Oxide and Endothelin Effects
- Adenosine and Purinergic Signaling
- Soil Carbon and Nitrogen Dynamics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Anesthesia and Neurotoxicity Research
- Radiomics and Machine Learning in Medical Imaging
- Neuroinflammation and Neurodegeneration Mechanisms
- Frailty in Older Adults
- Lung Cancer Diagnosis and Treatment
- Cholinesterase and Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Glaucoma and retinal disorders
- Injury Epidemiology and Prevention
- Pharmacological Receptor Mechanisms and Effects
- Biological and pharmacological studies of plants
- Wnt/β-catenin signaling in development and cancer
- Cancer, Stress, Anesthesia, and Immune Response
Jiangmen Central Hospital
2024-2025
Inner Mongolia University of Science and Technology
2025
National University Health System
2025
Guangzhou University of Chinese Medicine
2015-2024
Shandong Provincial Hospital
2008-2024
Shandong First Medical University
2022-2024
General Administration of Sport of China
2023
Beijing Sport University
2023
Gansu Provincial Maternal and Child Health Hospital
2023
Hebei North University
2021
Sinomenine (SIN), an alkaloid extracted from the Chinese herbal medicine Sinomenium acutum, has great potential in anti-inflammatory, immune regulation, analgesic and sedative, is already a clinical drug for treatment of rheumatoid arthritis China. Our previous studies show SIN inhibits inflammation by regulating ɑ7nAChR, key receptor cholinergic anti-inflammatory pathway (CAP), which plays important role peripheral central nervous system inflammation. Growing evidence supports dysregulation...
Introduction Smoking is associated with significant alterations in sleep architecture. Previous studies have revealed changes the subjective of young smokers, but research on objective assessment using polysomnography (PSG) limited. This study aims to explore electroencephalography (EEG) power and spindle activity during as well assess relationship between smoking variables. Methods We collected overnight PSG data from 19 smokers 16 non-smokers assessed nicotine dependence cumulative effects...
With aging populations, the prevalence of dementia, frailty and malnutrition will increase. The aim this study is twofold (a) to determine demographic data, including in older patients with diagnosis dementia and/or cognitive impairment (b) its impact on outcomes such as length stay (LOS), readmission mortality stratified by status. Retrospective single-center cohort conducted using hospital database ≥65 yrs. admitted a tertiary between March 2022 Dec 2023 discharged either primary or...
Considerable evidence suggests that depression is related to interhemispheric functional coordination deficits. For depression, electroconvulsive therapy (ECT) the most rapid and effective therapy, but its underlying mechanism remains unknown. The aim of this study was explore impact ECT on in patients. We used resting-state magnetic resonance imaging observe change with method voxel-mirrored homotopic connectivity (VMHC) 11 depressed patients before after ECT, compared 15 healthy controls....
Cysteinyl leukotrienes (CysLTs) are potent inflammatory mediators that predominantly exert their effects by binding to cysteinyl leukotriene receptors of the G protein-coupled receptor family. CysLT 2 (CysLT<sub>2</sub>R), expressed in endothelial cells some vascular beds, has been implicated a variety cardiovascular functions. Endothelium-specific overexpression human CysLT<sub>2</sub>R transgenic mice (hEC-CysLT<sub>2</sub>R) greatly increases myocardial infarction damage. Investigation...
Sinomenine (SIN), an alkaloid derived from the plant Sinomenium acutum, has anti-inflammatory and analgesic effects been used for rheumatoid arthritis treatment in China. This study aims to verify hypothesis that SIN acts on α7 nicotinic acetylcholine receptor (α7nAChR) inhibit activation of macrophages stimulated by lipopolysaccharide. The prototypical α7nAChR antagonist α-bungarotoxin mecamylamine attenuated effect tumor necrosis factor-α interleukin-6 RAW264.7 murine macrophage-like cells...
Isoorientin has anti-inflammatory effects; however, the mechanism remains unclear. We previously found isoorientin is an inhibitor of glycogen synthase kinase 3β (GSK3β) in vitro. Overactivation GSK3β associated with inflammatory responses. inactivated by phosphorylation at Ser9 (i.e., p-GSK3β). Lithium chloride (LiCl) inhibits and also increases p-GSK3β (Ser9). The present study investigated effect via regulation lipopolysaccharide- (LPS-) induced RAW264.7 murine macrophage-like cells...
Physalin E is a naturally occurring seco-steroid isolated from the stems and aerial parts of Physalis angulata L. (Solanaceae). This study was aimed to explore anti-inflammatory effects physalin on RAW 264.7 mouse macrophages stimulated by lipopolysaccharide (LPS) potential underlying mechanisms. The results showed that significantly inhibited LPS-induced tumor necrosis factor-α (TNF-α) interleukin-6 (IL-6) expression secretion in dose-dependent manner. Unlike dexamethasone, these could not...
This study aimed to utilize single-cell RNA sequencing (scRNA-seq) elucidate the autophagic landscape in breast cancer and develop a prognostic model for patients based on traditional high-throughput (bulk RNA-seq). We analyzed scRNA-seq data from GSE75688 dataset explore expression patterns of autophagy-related genes (ARGs) across distinct cellular clusters. ARGs were retrieved GeneCards database, bulk RNA-seq obtained The Cancer Genome Atlas (TCGA). Cox proportional hazards regression was...
ABSTRACT Tobacco use causes more than 8 million deaths globally each year, and the number of younger smokers is growing. It great practical importance to explore underlying neural mechanisms behind behaviour young smokers. During cue‐induced craving, reward system in brain generates oscillations at specific frequencies. The phase–amplitude coupling (PAC) can capture interactions between these frequencies may be a sensitive quantitative indicator for characterizing abnormal We monitored...
An uncontrolled inflammation induced critical health problems with serious morbidity and death, which namely acute lung injury (ALI). Recently researchs have found the anti-inflammatory effects of emodin. Here, we investigated potential emodin on a mouse model lethal dose mechanisms lipopolysaccharide (LPS)-induced inflammatory in mice. The pulmonary histological abnormalities, Evans blue's leakage, myeloperoxidase (MPO) activity, grades TNF-α, IL-6, nitric oxide (NO), lactic acid (LA)...
Abstract Background Falls are an important cause of injury and death older people. Hence, analyzing the multifactorial risk falls from past cases to develop intervention programs is clinically significant. However, due small sample size, there few studies on fall analysis clinical characteristics fallers, especially among hospitalized patients. Methods We collected data 153 inpatients who fell (age ≥ 60 years) hospital nursing adverse event reporting system during hospitalization at Shandong...
Leukotrienes have been implicated in the pathogenesis of degenerative diabetic retinopathy, with research focusing primarily on leukotriene B4, little attention devoted to cysteinyl leukotrienes (cysLTs), which act through cysLT receptors (CysLT1R and CysLT2R). We demonstrate here presence CysLT2R pericytes endothelial cells superficial retinal vasculature using an indirect assay by assessment β-galactosidase expression CysLT2R-knockout (KO) mice. Retinal damage was induced KO wild-type (WT)...
Abstract Lung cancer is the leading cause of deaths worldwide, with a high morbidity and less than 20% survival rate. Therefore, new treatment strategies drugs are needed to reduce mortality patients lung cancer. α7 nicotinic acetylcholine receptor (α7 nAChR), as nicotine its metabolites, potential target for treatment. Our previous studies revealed that sinomenine plays anti-inflammation roles via nAChR down-regulates expression this receptor, thus increasing inflammatory response. Hence,...
The cysteinyl leukotrienes (cysLTs) LTC<sub>4</sub>, LTD<sub>4</sub>, and LTE<sub>4</sub> are lipid mediators with physiological pathophysiological functions. They exert their effects through G protein-coupled receptors (GPCRs), most notably via CysLT<sub>1</sub> CysLT<sub>2</sub> receptor. roles of the receptor beginning to emerge. Both LTC<sub>4</sub> LTD<sub>4</sub> potent agonists for receptor; however, is rapidly converted which also main endogenous ligand A selective agonist at would...