A5101836710- Inflammatory Bowel Disease
- Pharmacological Effects of Natural Compounds
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Ginseng Biological Effects and Applications
- Psoriasis: Treatment and Pathogenesis
- Medicinal Plant Pharmacodynamics Research
- Diet and metabolism studies
- Digestive system and related health
- Vagus Nerve Stimulation Research
- Antibiotic Resistance in Bacteria
- Virus-based gene therapy research
- Helicobacter pylori-related gastroenterology studies
- Synthesis and Biological Evaluation
- Animal Virus Infections Studies
- Immune Cell Function and Interaction
- Medical Research and Treatments
- Gastrointestinal motility and disorders
- Reproductive System and Pregnancy
- Osteoarthritis Treatment and Mechanisms
- Synthesis of Indole Derivatives
- Nicotinic Acetylcholine Receptors Study
- Synthesis of Organic Compounds
- Catalytic C–H Functionalization Methods
- Pancreatic function and diabetes
Guangzhou University of Chinese Medicine
2018-2025
Guizhou University
2023
Chongqing Medical University
2014-2022
Shenzhen Second People's Hospital
2021
Harbin Medical University
2017
Guizhou Normal University
2013
Nanjing Agricultural University
2012
Guangzhou Liwan District Traditional Chinese Medicine Hospital
2010-2011
Kwansei Gakuin University
2005-2009
Guangzhou University
2004
Sinomenine (SIN), an alkaloid extracted from the Chinese herbal medicine Sinomenium acutum, has great potential in anti-inflammatory, immune regulation, analgesic and sedative, is already a clinical drug for treatment of rheumatoid arthritis China. Our previous studies show SIN inhibits inflammation by regulating ɑ7nAChR, key receptor cholinergic anti-inflammatory pathway (CAP), which plays important role peripheral central nervous system inflammation. Growing evidence supports dysregulation...
Ginsenoside Rg2 has been previously reported to reduce glucose production and adipogenesis in adipose tissue. However, the effects of ginsenosides on hepatic lipid metabolism remain vacant. In this study, we found that ginsenoside treatment significantly attenuated oleic acid palmitic (OA&PA)-induced intracellular deposition oxidative stress mouse primary hepatocytes. C57BL/6J mice are fed with a high-fat diet (HFD) treated displayed decreased body weight, reversed steatosis, improved...
Objective: This study aims to investigate the effect of astragaloside Ⅳ on adipose lipolysis and hepatic gluconeogenesis. Methods: High-fat diet (HFD) feeding induced dysfunction with enhanced endogenous glucose production in mice. The effects Astragaloside were investigated. Results: HFD cAMP accumulation through reducing PDE3B expression activity tissue. As a result, increased Akt phosphorylation promoted binding preserve content, resultantly accumulation. Knockdown Akt1/2 diminished...
Abstract Aim This study has conducted a comparative analysis of common carbapenemases harboring, the expression resistance-nodulation-cell division (RND) family efflux pumps, and biofilm formation potential associated with carbapenem resistance among Acinetobacter baumannii (A. ) strains different susceptibility. Methods: A total 90 isolates A. from two tertiary hospitals China were identified grouped as susceptible (CSAB) non-susceptible (CnSAB) based on susceptibility to imipenem....
Background Periplanta americana extract (PAE), a traditional Chinese medicine (TCM) from Shen Nong Ben Cao Jing , has been used to treat ulcerative colitis (UC), various types of wounds and ulcers, infantile malnutrition, palpitation, asthma, so on. However, the exact mechanisms PAE in UC have still not fully revealed. The study aims explore therapeutic effects UC. Methods efficacy was evaluated using DSS-induced mice model colon inflammation mucosal barrier were comprehensively assessed....
Jiangqi Dingchuan Pill (JDP) is a patent Chinese medicine in the treatment of asthma. JDP consists six herbal drugs, namely, Ephedrae Herba, Mori Cortex, Citri Reticulatae Pericarpium, Perillae Fructus, Descurainiae Semen, Sinapis Semen. To employ tools network pharmacology and vivo experiments, exploring possible mechanism treating chronic obstructive pulmonary disease (COPD). Chemical constituents JDP, collection targets COPD, target prediction were conducted, then pharmacological analysis...
A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, was obtained in 39% overall yield using a Goldberg coupling key step. The represents convenient procedure for production rivaroxaban.
Colitis-associated cancer (CAC) has been linked to microRNA (miRNA) aberrant expression elicited by inflammation. In this study, we used the AOM/DSS-induced CAC mice model explore ectopic of miRNAs in precancerous stage CAC. As a result, found that miR-31-5p, miR-223-3p, and let-7f-5p were dysregulated during development intestinal dysplasia. Subsequently, first identified role these three Adenomatous polyposis coli (APC) was revealed as new target solute carrier family 9- subfamily A-member...