A5101627629- Forensic and Genetic Research
- Molecular Biology Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Genetic diversity and population structure
- Ginseng Biological Effects and Applications
- Adipose Tissue and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Pharmacogenetics and Drug Metabolism
- Toxic Organic Pollutants Impact
- Inflammatory Bowel Disease
- Per- and polyfluoroalkyl substances research
- Natural product bioactivities and synthesis
- Gut microbiota and health
- Forensic Anthropology and Bioarchaeology Studies
- Sirtuins and Resveratrol in Medicine
- Genomics, phytochemicals, and oxidative stress
- Galectins and Cancer Biology
- Environmental DNA in Biodiversity Studies
- Phytochemical Studies and Bioactivities
- Genetic Associations and Epidemiology
- Inflammasome and immune disorders
- Phytochemistry and Bioactive Compounds
Guangzhou University of Chinese Medicine
2015-2025
Nanjing Tech University
2024
University of South China
2007-2023
First Affiliated Hospital of University of South China
2007-2023
Institute of Forensic Science
2014-2023
Southern Medical University
2021
Dezhou University
2017-2019
Nanyang Technological University
2011-2013
Siemens Healthcare (United States)
2013
Guangdong Polytechnic of Science and Technology
2013
We wished to develop a highly selective positron emission tomography (PET) imaging agent targeting PHF-tau in human Alzheimer's disease (AD) brains.To screen potential tau binders, AD brain sections were used as source of native paired helical filament (PHF)-tau and Aβ rather than synthetic aggregates or fibrils generated vitro measure the affinity selectivity [(18)F]T807 Aβ. Brain uptake biodistribution mice also tested.In autoradiography results show that exhibits strong binding...
Senile plaques and neurofibrillary tangles are prominent neuropathological hallmarks in Alzheimer's disease considered to be targets for therapeutic intervention as well biomarkers diagnostic vivo imaging agents. While there a n
The effects of exposure concentration on the bioaccumulation four perfluorinated chemicals (PFCs): perfluorooctanesulfonate (PFOS), perfluoroocanoic acid (PFOA), perfluorononanoic (PFNA), and perfluorodecanoic (PFDA), was investigated using green mussels, Perna viridis. Mussels were exposed to concentrations 1 μgL–1 10 each PFC for 56 days, factors (BAF) found range from 15 859 L/kg 12 473 at μgL–1, respectively. For all compounds, BAF larger lower dosage. Results suggest that PFCs is...
Objective Impaired hepatic fatty acids oxidation results in lipid accumulation and redox imbalance, promoting the development of liver diseases insulin resistance. However, underlying pathogenic mechanism is poorly understood. Krüppel-like factor 16 (KLF16) a transcription that abounds liver. We explored whether by what mechanisms KLF16 affects catabolism to improve hepatosteatosis Design expression was determined patients with non-alcoholic disease (NAFLD) mice models. The role regulation...
Vascular smooth muscle cells (VSMCs) were prepared from thoracic aortas of male Sprague-Dawley rats by the explant method to observe VSMC proliferation via phosphoinositide 3 kinase (PI3K)/Akt signaling transduction pathway induced apelin-13. Expression PI3K, phospho-PI3K, phospho-Akt, ERK1/2, phospho-ERK1/2 and cyclin D1 was detected western blot analysis. Results showed that apelin-13 promoted expression phospho-PI3K phospho-Akt in dose- timedependent manner. PI3K inhibitor LY294002...
Cardiovascular calcification is one of the most severe outcomes associated with cardiovascular disease and often results in significant morbidity mortality. Previous reports indicated that epigenomic regulation microRNAs (miRNAs) might play important roles vascular smooth muscle cell (VSMC) calcification. Here, we identified potential key miRNAs involved vivo investigated role miR-32-5p (miR-32). According to microarray analysis, observed increased expression miR-125b, miR-30a, miR-32...
Vitexin, one of the major active components in hawthorn, has been shown to possess multiple pharmacological activities. Here, we sought investigate effect vitexin on an ameliorating dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) mouse model and further explored its potential mechanism. The results indicated that administration could significantly alleviate signs via suppressing body weight loss, reducing disease activity index (DAI) score, mitigating colonic damage. Also,...
Ginsenoside Rg2 has been previously reported to reduce glucose production and adipogenesis in adipose tissue. However, the effects of ginsenosides on hepatic lipid metabolism remain vacant. In this study, we found that ginsenoside treatment significantly attenuated oleic acid palmitic (OA&PA)-induced intracellular deposition oxidative stress mouse primary hepatocytes. C57BL/6J mice are fed with a high-fat diet (HFD) treated displayed decreased body weight, reversed steatosis, improved...
Aims: Acetaminophen (APAP) overdose leads to acute liver injury by inducing hepatic mitochondrial oxidative stress and inflammation. However, the molecular mechanisms involved are still unclear. Farnesoid X receptor (FXR) serves as a therapeutic target for treatment of disorders, whose activation has been proved protect APAP-induced hepatotoxicity. In this study, we examined whether FXR schaftoside (SS), naturally occurring flavonoid from Desmodium styracifolium, could mice against...
The excessive accumulation of bile acids (BA) in hepatocytes can trigger inflammatory response and recruit macrophages, thereby accelerating cholestatic liver injury. crosstalk between macrophages has been recently implicated the pathogenesis cholestasis; however, underlying mechanisms remain unclear. Here, we demonstrated that BA initiate NLRP3 inflammasome activation to release proinflammatory cytokines promote communication thus enhancing inflammation an NLRP3-dependent manner....
Insertion/deletion polymorphisms (InDels) have particular characteristics, such as a relatively low mutation rate, small amplicon size, and no stutter artifacts when genotyped via the capillary electrophoresis platform. It would be an important complementary tool for individual identification certain kinship analyses. At present, massively parallel sequencing (MPS) has shown excellent application value in forensic studies. Therefore, this study, we developed custom MPS InDel panel that...
Abstract Perfluorinated chemicals (PFCs) are a group of compounds with varying carbon chains and functional groups. Currently, available toxicity studies PFCs limited mainly to dominant species. While many other detected in the environment biota, it is important extend different types better assess their environmental ecological impacts. In present study, perfluorooctanesulfonate, perfluoroocanoic acid, perfluorononanoic perfluorodecanoic acid were evaluated green mussel, Perna viridis ,...
Activation of the human pregnane X receptor (PXR; NR1I2) has potential therapeutic uses for inflammatory bowel disease (IBD). Imperatorin (IMP), a naturally occurring coumarin, is main bioactive ingredient Angelica dahurica Radix, which regularly used to treat common cold and intestinal disorders. However, there are no data on protective effects IMP against IBD.
A new 19 X- short tandem repeat (STR) multiplex PCR system has recently been developed, though its applicability in forensic studies not thoroughly assessed. In this study, 932 unrelated individuals from four Chinese ethnic groups (Han, Tibet, Uighur and Hui) were successfully genotyped using system. Our results showed significant linkage disequilibrium between markers DXS10103 DXS10101 all groups; DXS10159 DXS10162, DXS6809 DXS6789, HPRTB Tibetan populations; DXS10074 DXS10075 populations....
Acetaminophen (APAP) toxicity leads to severe acute liver injury (ALI) by inducing excessive oxidative stress, inflammatory response, and hepatocyte apoptosis. Imperatorin (IMP) is a furanocoumarin from Angelica dahurica, which has antioxidant anti-inflammatory effects. However, its potential ameliorate ALI unknown. In this study, APAP-treated genetic knockout of Farnesoid X receptor (FXR) Sirtuin 1 (SIRT1) mice were used for research. The results revealed that IMP could improve the severity...