A5009653481- Liver Disease Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Phytochemistry and biological activity of medicinal plants
- Drug-Induced Hepatotoxicity and Protection
- Sirtuins and Resveratrol in Medicine
- Lipid metabolism and disorders
- Genomics, phytochemicals, and oxidative stress
- Endoplasmic Reticulum Stress and Disease
- Inflammasome and immune disorders
- Sexual function and dysfunction studies
- Drug Transport and Resistance Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Gut microbiota and health
- Caveolin-1 and cellular processes
- Plant biochemistry and biosynthesis
- Inflammatory Bowel Disease
- Traditional and Medicinal Uses of Annonaceae
- Menopause: Health Impacts and Treatments
- Cancer Mechanisms and Therapy
- Pregnancy and Medication Impact
- Blood disorders and treatments
- Computational Drug Discovery Methods
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2016-2024
Guangzhou University of Chinese Medicine
2020-2024
Kashi University
2023
Xinjiang Medical University
2021
People's Hospital of Xinjiang Uygur Autonomous Region
2020-2021
First Affiliated Hospital of Xinjiang Medical University
2021
Objective Impaired hepatic fatty acids oxidation results in lipid accumulation and redox imbalance, promoting the development of liver diseases insulin resistance. However, underlying pathogenic mechanism is poorly understood. Krüppel-like factor 16 (KLF16) a transcription that abounds liver. We explored whether by what mechanisms KLF16 affects catabolism to improve hepatosteatosis Design expression was determined patients with non-alcoholic disease (NAFLD) mice models. The role regulation...
Abstract A lasting imbalance between fatty acid synthesis and consumption leads to non-alcoholic liver disease (NAFLD), coupled with hepatitis insulin resistance. Yet the details of underlying mechanisms are not fully understood. Here, we unraveled that expression transcription factor Zbtb18 is markedly decreased in livers both patients murine models NAFLD. Hepatic knockout promoted NAFLD features like impaired energy expenditure oxidation (FAO), induced Conversely, hepatic overexpression...
Chronic renal failure (CRF) threatens human health greatly and attracts worldwide concerns of professionals in the public sector. In our preliminary study, we found that Compound capsule (Shengqing Jiangzhuo Capsule, SQJZJN) had a significant therapeutic effect on CRF. Quercetin is one main components this capsule. investigated monomer CRF regulation PI3k/Akt pathway. Network pharmacology analysis methods were employed to analyze SQJZJN/Quercetin/PIK3R1 network relationships. rat model was...
Cassia mimosoides Linn (CMD) is a traditional Chinese herb that clears liver heat and dampness. It has been widely administered in clinical practice to treat jaundice associated with damp-heat pathogen obesity. Emodin (EMO) major bioactive constituent of CMD apparent therapeutic efficacy against obesity fatty liver. Here, we investigated the protective effects underlying mechanisms EMO high-fat diet (HFD)-induced nonalcoholic disease (NAFLD).We aimed investigate whether activates farnesoid X...
Alcoholic liver disease (ALD) is a serious worldwide health problem. Ginsenoside Rc major active ingredient isolated from Panax ginseng, whose pharmacological effects counteract oxidative stress, inflammation, and lipid accumulation. However, it still unclear whether ginsenoside might exert beneficial on alcohol-induced injury. To this aim, mice primary hepatocytes (MPHs) were challenged with alcohol to test Rc's their intracellular metabolism. C57BL/6J or SIRT6alb-/- chronically fed diet...
Aims: Acetaminophen (APAP) overdose leads to acute liver injury by inducing hepatic mitochondrial oxidative stress and inflammation. However, the molecular mechanisms involved are still unclear. Farnesoid X receptor (FXR) serves as a therapeutic target for treatment of disorders, whose activation has been proved protect APAP-induced hepatotoxicity. In this study, we examined whether FXR schaftoside (SS), naturally occurring flavonoid from Desmodium styracifolium, could mice against...
The excessive accumulation of bile acids (BA) in hepatocytes can trigger inflammatory response and recruit macrophages, thereby accelerating cholestatic liver injury. crosstalk between macrophages has been recently implicated the pathogenesis cholestasis; however, underlying mechanisms remain unclear. Here, we demonstrated that BA initiate NLRP3 inflammasome activation to release proinflammatory cytokines promote communication thus enhancing inflammation an NLRP3-dependent manner....
Chrysophanol, a primary active ingredient of Cassia mimosoides Linn or Rhei radix et rhizoma, has various pharmacological properties, including anticancer, antidiabetic, and anti-inflammatory, as well blood lipid regulation. However, whether chrysophanol can mitigate obesity, its underlying mechanisms remains unclear. This study investigated effects energy metabolism in high-fat diet- (HFD-) induced obese mice fat-specific Sirtuin 6- (SIRT6-) knockout (FKO) mice, targeting the SIRT6/AMPK...
Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent health issues. The improvement NAFLD related to activation farnesoid X receptor (FXR). Typhaneoside (TYP) main component Typha orientalis Presl, which plays a positive role in resistance glucose and lipid metabolism disorders. This study aims investigate alleviative effect underlying mechanism TYP on OAPA-induced cells high-fat-diet (HFD)-induced mice with disorders metabolism, inflammation, oxidative stress lower...
Pachymic acid (Pac), a major bioactive constituent of Poria cocos, is an antioxidant that inhibits triglyceride (TG) accumulation. To the best our knowledge, present study investigated for first time whether Pac activated sirtuin 6 (SIRT6) signaling to alleviate oleic (OA)-palmitic (PA)-induced lipid metabolism disorders in mouse primary hepatocytes (MPHs). In study, MPHs challenged with were used test effects on intracellular metabolism. Molecular docking studies performed explore potential...
Abstract Cassia mimosoides Linn has been used from ancient times and for treating hepatitis its supposedly medically beneficial properties. In this study, different constituents of the (β-Sitosterol, Oleanolic Acid, Emodin, Carotene, Resorcinol, Luteolin, α-L-Rhamnose) were evaluated potential anti-HMG-CoA reductase effect. The inhibitory effects HMG-CoA extracts Pravastatin inhibitor at concentrations (at doses 1, 5, 25 or 125 μg/mL, respectively) in reaction system (70 mmol/L phosphate...
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A simple, rapid and sensitive analytical method was developed for the determination of toosendanin in rat plasma using liquid chromatography tandem mass spectrometry (LC-MS/MS). Andrographolide selected as internal standard, samples were extracted by liquid-liquid extraction with diethyl ether. Chromatographic separation performed on a Dikma Spursil C18, 3.5 μm (150 × 2.1 mm i.d) column 85% methanol:water (v/v) containing 0.025% formic acid (pH = 3.9) mobile phase. The flow rate 0.25 mL/min,...
Jianpi Huayu decoction (JHD) is a traditional Chinese medicinal preparation used to treat variety of malignant tumors including HCC, although the underlying mechanism remains unknown. Exosomes in tumor microenvironment mediate intercellular signaling among cancer cells, but precise contributions hepatocellular carcinoma (HCC) progression are still elusive.In this work, main objective was examine mechanisms anti-tumor effects JHD and potential exosomal signaling.LC-MS/MS for Quality control...