A5062413505- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Ginkgo biloba and Cashew Applications
- Blood Pressure and Hypertension Studies
- Nephrotoxicity and Medicinal Plants
- Liver Disease Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
- Diabetes Treatment and Management
- Natural Compounds in Disease Treatment
- Atrial Fibrillation Management and Outcomes
- Cancer-related molecular mechanisms research
- Erythrocyte Function and Pathophysiology
- Cardiac tumors and thrombi
- Traditional Chinese Medicine Analysis
- Hemoglobinopathies and Related Disorders
- Natural product bioactivities and synthesis
- Cardiovascular Function and Risk Factors
- Diabetes Management and Research
- Phytochemistry and biological activity of medicinal plants
- Hemodynamic Monitoring and Therapy
- TGF-β signaling in diseases
- Caveolin-1 and cellular processes
- Sodium Intake and Health
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2013-2024
Guangzhou University
2010
ABSTRACT Background Finerenone, a non-steroidal mineralocorticoid receptor antagonist, improved kidney and cardiovascular outcomes in patients with chronic disease (CKD) type 2 diabetes two phase 3 outcome trials. The addition to standard of care, on the progression Non-Diabetic Chronic Kidney Disease (FIND-CKD) study investigates effect finerenone adults CKD without diabetes. Methods FIND-CKD (NCT05047263 EU CT 2023-506897-11-00) is randomized, double-blind, placebo-controlled trial...
Chronic renal failure (CRF) threatens human health greatly and attracts worldwide concerns of professionals in the public sector. In our preliminary study, we found that Compound capsule (Shengqing Jiangzhuo Capsule, SQJZJN) had a significant therapeutic effect on CRF. Quercetin is one main components this capsule. investigated monomer CRF regulation PI3k/Akt pathway. Network pharmacology analysis methods were employed to analyze SQJZJN/Quercetin/PIK3R1 network relationships. rat model was...
Chinese herbal medicine (CHM) might have benefits in patients with non-diabetic chronic kidney disease (CKD), but there is a lack of high-quality evidence, especially CKD4. This study aimed to assess the efficacy and safety Bupi Yishen Formula (BYF) vs. losartan trial was multicenter, double-blind, double-dummy, randomized controlled that carried out from 11-08-2011 07-20-2015. Patients were assigned (1:1) receive either BYF or for 48 weeks. The primary outcome change slope estimated...
Abstract Background Recommended regular saline flushing presents clinical ineffectiveness for hemodialysis (HD) patients at high risk of bleeding with heparin contraindication. Regional citrate anticoagulation (RCA) has previously been used a Ca 2+ containing dialysate prefiltered in one arm (RCA-one). However, is not always achievable and up to 40% results serious clotting the venous expansion chamber. In this study, we have transferred one-quarter TSC from post filter based on RCA-one,...
Tanshinone ⅡA (TⅡA) is widely used for the treatment of a number human diseases, including diabetic nephropathy (DN) (1). The present study was performed to examine role transforming growth factor β (TGFβ)/p65 pathway under TⅡA in glomerular mesangial cell model DN. Firstly, it identified that inhibited proliferation HBZY‑1 cells, while simultaneously suppressing expression TGFβ and p65. In addition, glucose-induced cells were treated with TⅡA, si‑TGFβ si‑p65. results revealed or si‑p65 able...
Wenyang Lishui decoction (WYD) has been frequently used to treat patients with membranous nephropathy (MN) in China. Our previous study vitro showed that WYD aqueous extract could alleviate F‐actin reorganization of podocytes induced by serum from idiopathic (IMN) patients. This aims investigate the effects and molecular mechanisms on MN. MN rat models were cationic bovine albumin. Experimental rats divided into four groups: normal, model, WYD, benazepril. The normal group consisted...
Renal fibrosis, the leading cause of end-stage renal disease and in which epithelial-mesenchymal transition (EMT) plays a central role, has complex pathogenesis that is not fully understood. Therefore, we investigated role long noncoding RNA LUCAT1 EMT tubular epithelial cells under high-glucose (HG) conditions underlying mechanism involved. In this study, established HG normal glucose groups HK-2 by treating 30.0 or 5.5 mmol/L glucose, respectively. To investigate roles miR-199a-5p...
Lupus nephritis (LN) occurs in ~50% of patients with systemic lupus erythematosus and is a major cause morbidity mortality the affected individuals. Therefore, identification novel predictive biomarkers for early diagnosis progression LN required. The present study included 10 whose diagnoses were confirmed by renal biopsy 5 healthy participants as control subjects. Sera collected both from controls. Subsequently, mesangial cells treated these sera 24 h. Differential proteins between groups...
Cutaneous epithelioid angiomatous nodules (CEAN) are rare, benign, vascular lesions characterized by benign proliferation of endothelial cells with prominent features, which can be easily confused and malignant tumors. However, the etiology CEAN remains unclear, no association infection, trauma, or immunosuppression has been described. This case study indicated that is closely related to patient's impaired immune status may induced cyclosporine.A 19-year-old boy nephrotic syndrome (NS)...
Context Four algorithms with relatively balanced complexity and accuracy in deep learning classification algorithm were selected for differential diagnosis of primary membranous nephropathy (PMN).
Cholesterol crystal embolization (CCE) is a multisystemic and fatal disease with multiple clinical manifestations; however, there are few cases of idiopathic CCE. Here we report patient CCE accompanied by atheroembolic renal blue toes who had relatively good prognosis in the short-term due to early treatment corticosteroids statins.A 76-year-old man complained coldness, numbness purple color change his left foot for 7 d. He feeling fatigue, constipation, foamy urine, poor appetite sleep....
Objective This study aimed to assess the clinical efficacy and safety of treatment refractory nephrotic syndrome with integrated traditional Chinese western medicine. Methods The was a prospective, randomized, double-blind, 2∶1 basic-control, multi-center trial, 120 patients recruited from 7 hospitals in China. The test group administered medicine (TCM) particles on base prednisone cyclophosphamide for 3 months, while control placebo using same method. 24-hour urinary protein, serum...