A5006762629- Renal Diseases and Glomerulopathies
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Structural Analysis and Optimization
- Composite Structure Analysis and Optimization
- Vibration and Dynamic Analysis
- Structural Load-Bearing Analysis
- Hepatitis B Virus Studies
- Inflammasome and immune disorders
- Systemic Lupus Erythematosus Research
- Liver Disease Diagnosis and Treatment
- Structural Engineering and Vibration Analysis
- Hepatitis C virus research
- Cardiac, Anesthesia and Surgical Outcomes
- Autophagy in Disease and Therapy
- Central Venous Catheters and Hemodialysis
- Atrial Fibrillation Management and Outcomes
- Cell death mechanisms and regulation
- Parathyroid Disorders and Treatments
- Numerical methods in engineering
- Adenosine and Purinergic Signaling
- GDF15 and Related Biomarkers
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
Guangdong Academy of Medical Sciences
2016-2025
Southern Medical University
2013-2025
Guangdong Provincial People's Hospital
2005-2025
First Affiliated Hospital of Guangzhou Medical University
2022-2025
State Key Laboratory of Respiratory Disease
2023-2025
Guangzhou Medical University
2022-2025
Zhuhai People's Hospital
2025
South China University of Technology
2025
Harbin Institute of Technology
2025
Capital Medical University
2010-2024
Acute lung injury is a leading cause of death in bacterial sepsis due to the wholesale destruction endothelial barrier, which results protein-rich edema, influx proinflammatory leukocytes, and intractable hypoxemia. Pyroptosis form programmed lytic cell that triggered by inflammatory caspases, but little known about its role EC acute injury. Here, we show systemic exposure endotoxin lipopolysaccharide (LPS) causes severe pyroptosis mediated human caspases 4/5 ECs, or murine homolog...
Unchecked inflammation is a hallmark of inflammatory tissue injury in diseases such as acute respiratory distress syndrome (ARDS). Yet the mechanisms lung remain largely unknown. Here we showed that bacterial endotoxin lipopolysaccharide (LPS) and cecal ligation puncture–induced (CLP-induced) polymicrobial sepsis decreased expression transcription factor cAMP response element binding (CREB) endothelial cells. We demonstrated CREB was crucial for VE-cadherin formation normal restrictive...
ABSTRACT Background Plasma protein has gained prominence in the non‐invasive predicting of lung cancer. We utilised Zeolite Zotero NaY‐based plasma proteomics to investigate its potential for multiple event predicting, including cancer diagnosis (task #1), lymph node metastasis detection #2) and tumour‒node‒metastasis (TNM) staging #3). Methods A total 4703 proteins were quantified from 241 participants based on a prospective cohort 2757 participants. An additional 46 external 735 used...
Brain metastasis is thought to be related the high mortality and poor prognosis of lung cancer. Despite significant advances in treatment primary cancer, unique microenvironment brain renders current therapeutic strategies largely ineffective against metastasis. The lack effective drugs for primarily due incomplete understanding mechanisms underlying its initiation progression. Currently, our remains limited, absence appropriate models that can realistically simulate entire process tumor...
Podocyte injury plays a key role in the development of diabetic nephropathy (DN). We have recently shown that 11R-VIVIT, an inhibitor cell-permeable nuclear factor activated T-cells (NFAT), attenuates podocyte apoptosis induced by high glucose vitro. However, it is not known whether 11R-VIVIT has protective effect on DN, especially injury, under vivo conditions. Hence, we examined renoprotective effects db/db mice and possible mechanisms underlying its vitro.Type 2 received i.p. injections...
<b><i>Background/Aims:</i></b> Acute kidney injury (AKI) is a serious complication of sepsis and has high morbidity mortality rate. Caspase-11 induces pyroptosis, form programmed cell death that plays critical role in endotoxic shock, but its tubular epithelial whether it contributes to sepsis-associated AKI remains unknown. <b><i>Methods:</i></b> The caspase-11<sup>–/–</sup> mouse received an intraperitoneal injection...
The construction and inspection of reinforcement rebar currently rely entirely on manual work, which leads to problems such as high labor requirements costs. Rebar image detection using deep learning algorithms can be employed in quality intelligent construction; it check the number, spacing, diameter a site, guide robots complete tying. However, application relies large number datasets train models, while data collection annotation are time-consuming laborious. In contrast, synthetic...
Background Pulmonary hypertension (PH) was recently recognized as a common complication of end-stage renal disease (ESRD) that causes an increased risk mortality. Epidemiological data for this disorder in earlier stages chronic kidney (CKD) and its association with cardiovascular (CV) morbidity are scarce. Methods We retrospectively analyzed 2,351 Chinese CKD patients complete clinical records echocardiography between Jan 2008 May 2012. The were divided into the following 6 groups: Stages...
Acute kidney injury (AKI) with maladaptive tubular repair leads to renal fibrosis and progresses chronic disease (CKD). At present, there is no curative drug interrupt AKI-to-CKD progression. The nuclear factor of the activated T cell (NFAT) family was initially identified as a transcription expressed in most immune cells involved cytokine genes other critical for response. NFAT2 also epithelial (RTECs) podocytes plays an important regulatory role kidney. In this study, we investigated...
Abstract Autophagy is an important renal-protective mechanism in septic acute kidney injury (AKI). Receptor interacting protein kinase 3 (RIP3) has been implicated the renal tubular and dysfunction during AKI. Here we investigated role of RIP3 on autophagy We showed activation RIP3, accompanied by accumulation autophagosome marker LC3II autophagic substrate p62, kidneys lipopolysaccharide (LPS)-induced AKI mice LPS-treated cultured proximal epithelial cells (PTECs). The lysosome inhibitor...
Necrostatin-1 (Nec-1) inhibits necroptosis and is usually regarded as having no effect on other cell deaths. Here, this study explored whether the addition of Nec-1 has an death induced by simulated ischemia injury in rat tubular line NRK-52E. In addition, we also investigated mechanism attenuates renal model. The NRK-52E cells were incubated with TNF-α + antimycinA (TA) for 24 h or without Nec-1. Cell was observed under fluorescent microscope quantified flow cytometry. viabilities detected...
Acute kidney injury (AKI) induced by renal ischemia is a common clinical problem associated with high morbidity and mortality. The present study investigated whether necroptosis was in an vitro model the addition of necrostatin-1 (Nec-1) has protective effect. In addition, autophagy inhibited following use Nec-1 also examined. When apoptosis z-VAD‑fmk energy depleted antimycin A for 1 h, morphological abnormalities human proximal tubular epithelial (HK-2) cells were markedly attenuated, cell...
Glucocorticoid treatment is the first choice therapy for adults with minimal change nephrotic syndrome; however, this associates many adverse effects. Tacrolimus may be an alternative to conventional glucocorticoid therapy. To investigate possibility, we conducted a prospective, randomized, controlled trial (WHO International Clinical Trials Registry Platform: ChiCTR-TRC-11001454) in eight renal units across China. We randomized enrolled patients adult–onset syndrome ( n =119) receive or...
This study aimed to investigate the protective effect of necroptosis inhibitor necrosulfonamide (NSA) on intestinal epithelial cells using a novel in vitro model that mimics inflammatory bowel disease (IBD).2,4,6-trinitrobenzenesulfonic acid (TNBS) was perfused into rectum BALB/c mice established colitis model. Pathologic injury and cell death were evaluated. A Caco-2 TNF-α Z-VAD-fmk, treated with or without NSA. Morphologic changes, manner levels phosphorylation receptor-interacting protein...
Renal tubular epithelial cell apoptosis is an important pathological mechanism of septic acute kidney injury (AKI). Endotoxin, also known as lipopolysaccharide (LPS), has a key role in AKI and can directly induce apoptosis. The upregulation receptor‑interacting protein kinase 3 (RIPK3) cells been reported AKI, with RIPK3 mediating several types. In the present study, effect on endotoxin‑induced was investigated mouse vitro vivo. It found that expression markedly increased AKI....
Ischemia-reperfusion (I/R)-induced acute kidney injury (I/R-AKI) favors mitochondrial permeability transition pore (mPTP) opening and subsequent cell death. Cyclophilin D (CypD) is an essential component of the mPTP, recent findings have implicated p53-CypD complex in To evaluate role after I/R-AKI, we tested hypothesis that mediates renal tubular apoptosis I/R-AKI via mPTP opening. Expression p53 cleaved caspase-3 was significantly increased rats subjected to compared with normal controls...
IgA nephropathy (IgAN) is the most common primary glomerulonephritis, characterized by glomerular deposition of immune complexes, mainly produced B cells under regulation CD4 + T cells. However, alterations specific cell subsets and mechanism activation in IgAN remain unclear. Therefore, we aimed to investigate landscape characteristics role progression IgAN. We identified that proportion Th2, Th17 Tfh (follicular helper T) patients with was significantly higher than healthy controls ( P...