A5110861141- Sphingolipid Metabolism and Signaling
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammasome and immune disorders
- Neonatal Respiratory Health Research
- Animal Nutrition and Physiology
- ATP Synthase and ATPases Research
- Immune cells in cancer
- Antioxidant Activity and Oxidative Stress
- PI3K/AKT/mTOR signaling in cancer
- Pulmonary Hypertension Research and Treatments
- Hippo pathway signaling and YAP/TAZ
- Lipid metabolism and biosynthesis
- Agriculture Sustainability and Environmental Impact
- Heme Oxygenase-1 and Carbon Monoxide
- Erythrocyte Function and Pathophysiology
- Animal Behavior and Welfare Studies
- Free Radicals and Antioxidants
- Eicosanoids and Hypertension Pharmacology
- Lysosomal Storage Disorders Research
- Lipid Membrane Structure and Behavior
- Mitochondrial Function and Pathology
- Caveolin-1 and cellular processes
- Epigenetics and DNA Methylation
- Drug Transport and Resistance Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
Shanghai Jiao Tong University
2023-2025
Xiangtan University
2025
Tsinghua University
2018-2024
Sichuan Agricultural University
2019-2024
University of Illinois Chicago
2013-2023
Illinois College
2020-2023
Guangdong Pharmaceutical University
2023
Hunan University of Arts and Science
2022-2023
Xuzhou Medical College
2021
Jilin Agricultural University
2021
Unchecked inflammation is a hallmark of inflammatory tissue injury in diseases such as acute respiratory distress syndrome (ARDS). Yet the mechanisms lung remain largely unknown. Here we showed that bacterial endotoxin lipopolysaccharide (LPS) and cecal ligation puncture–induced (CLP-induced) polymicrobial sepsis decreased expression transcription factor cAMP response element binding (CREB) endothelial cells. We demonstrated CREB was crucial for VE-cadherin formation normal restrictive...
Sphingosine kinases (SphKs) 1 and 2 regulate the synthesis of bioactive sphingolipid sphingosine-1-phosphate (S1P), an important lipid mediator that promotes cell proliferation, migration, angiogenesis.We aimed to examine whether SphKs their product, S1P, play a role in development pulmonary arterial hypertension (PAH).SphK1(-/-), SphK2(-/-), S1P lyase heterozygous (Sgpl1(+/-)) mice, pharmacologic SphK inhibitor (SKI2), receptor (S1PR2) antagonist (JTE013) were used rodent models...
The sphingosine kinase 1 (SPHK1)/sphingosine–1–phosphate (S1P) signaling axis is emerging as a key player in the development of idiopathic pulmonary fibrosis (IPF) and bleomycin (BLM)-induced lung mice. Recent evidence implicates involvement Hippo/Yes-associated protein (YAP) pathway diseases, including IPF, but its plausible link to SPHK1/S1P unclear. Herein, we demonstrate increased co-localization YAP1 with fibroblast marker FSP1 fibroblasts BLM-challenged mice, genetic deletion Sphk1...
Idiopathic pulmonary fibrosis is a devastating disease characterized by alveolar epithelial cell injury, the accumulation of fibroblasts/myofibroblasts, and deposition extracellular matrix proteins. Lysophosphatidic acid (LPA) signaling through its G protein-coupled receptors critical for various biological functions. Recently, LPA receptor 1 were implicated in lung fibrogenesis. However, role other remains unclear. Here, we use bleomycin-induced model to investigate roles LPA2 In present...
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease, wherein transforming growth factor β (TGF-β) sphingosine-1-phosphate (S1P) contribute to the pathogenesis of fibrosis. However, in vivo contribution sphingosine kinase (SphK) fibrotic processes has not been documented. Microarray analysis blood mononuclear cells from patients with IPF SphK1- or SphK2-knockdown mice SphK inhibitor were used assess role SphKs fibrogenesis. The expression SphK1/2...
<h3>Introduction</h3> Idiopathic pulmonary fibrosis (IPF) is characterised by accumulation of fibroblasts and myofibroblasts deposition extracellular matrix proteins. Sphingosine-1-phosphate (S1P) signalling plays a critical role in fibrosis. <h3>Methods</h3> S1P lyase (S1PL) expression peripheral blood mononuclear cells (PBMCs) was correlated with functions overall survival; used murine model to check the S1PL on fibrogenesis cell culture system study effect transforming growth factor...
Potassium efflux via the two-pore K
Lysocardiolipin acyltransferase (LYCAT), a cardiolipin-remodeling enzyme regulating the 18:2 linoleic acid pattern of mammalian mitochondrial cardiolipin, is necessary for maintaining normal function and vascular development. We hypothesized that modulation LYCAT expression in lung epithelium regulates development pulmonary fibrosis.To define role human murine models fibrosis.We analyzed correlation peripheral blood mononuclear cells (PBMCs) with outcomes functions overall survival, used to...
Lysophosphatidylcholine is known to be a lipid mediator in various cellular responses. In this study, we examined the anti-inflammatory actions of lysophosphatidylcholine containing docosahexaenoic acid esterified at sn-1 position. First, RAW 264.7 cells, DHA-lysoPtdCho suppressed LPS-induced formation NO concentration-dependently. However, ARA-lysoPtdCho showed partial suppression, and LNA-lysoPtdCho had no significant effect. Additionally, also reduced level TNF-alpha or IL-6, but not...
Bronchopulmonary dysplasia of the premature newborn is characterized by lung injury, resulting in alveolar simplification and reduced pulmonary function. Exposure neonatal mice to hyperoxia enhanced sphingosine-1-phosphate (S1P) levels tissues; however, role increased S1P pathobiological characteristics bronchopulmonary has not been investigated. We hypothesized that an altered signaling axis, part, responsible for injury leading dysplasia. To validate this hypothesis, wild-type, sphingosine...
Caveolae are the primary route for internalization and transendothelial transport of macromolecules, such as insulin albumin. Caveolae-mediated endocytosis is activated by Src-dependent caveolin-1 (Cav-1) phosphorylation subsequent recruitment dynamin-2 filamin A (FilA), which facilitate vesicle fission trafficking, respectively. Here, we tested role RalA phospholipase D (PLD) signaling in regulation caveolae-mediated trafficking. The addition albumin to human lung microvascular endothelial...
Mechanical ventilation (MV) performed in respiratory failure patients to maintain lung function leads ventilator-induced injury (VILI). This study investigates the role of sphingolipids and sphingolipid metabolizing enzymes VILI using a rodent model alveolar epithelial cells subjected cyclic stretch (CS). MV (0 PEEP (Positive End Expiratory Pressure), 30 mL/kg, 4 h) mice enhanced sphingosine-1-phosphate lyase (S1PL) expression, ceramide levels, decreased S1P levels tissue, thereby leading...
Abstract Background Acid sphingomyelinase deficiency (ASMD) disorder, also known as Niemann–Pick disease (NPD) is a rare genetic caused by mutations in SMPD1 gene, which encodes sphingomyelin phosphodiesterase (ASM). Except for liver and spleen enlargement lung disease, two subtypes (Type A B) of NDP have different onset times, survival ASM activities, neurological abnormalities. To comprehensively explore NPD’s genotype-phenotype association pathophysiological characteristics, we collected...
Sphingosine-1-phosphate (S1P), a bioactive lipid, is generally increased in human non-small cell lung cancer (NSCLC). Evidence has shown that the levels of enzymes S1P metabolism were associated with clinical outcomes patients NSCLC. Nevertheless, roles mRNA expression major (SPHK1, SPHK2 and SGPL1) for predicting NSCLC have not been determined."The Kaplan-Meier plotter" (the KM plotter) an online database which contains gene data 1,928 patients. In this study, we analyzed relationship...