A5101880707- Livestock and Poultry Management
- Animal Nutrition and Physiology
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Biochemical Analysis and Sensing Techniques
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Cardiac Arrhythmias and Treatments
- Cardiac Fibrosis and Remodeling
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- RNA and protein synthesis mechanisms
- Medicinal Plants and Bioactive Compounds
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Genomics and Phylogenetic Studies
- Cardiovascular Issues in Pregnancy
- Biological and pharmacological studies of plants
- Adipose Tissue and Metabolism
- Extracellular vesicles in disease
- Phytochemistry and Biological Activities
- Heme Oxygenase-1 and Carbon Monoxide
- Parkinson's Disease Mechanisms and Treatments
The First People's Hospital of Zhaoqing
2025
Zhongshan Hospital
2019-2024
Fudan University
2019-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2022-2024
Sun Yat-sen University
2019-2024
Fujian Medical University
2024
Jiaying University
2020-2024
Zhejiang Normal University
2024
The First Affiliated Hospital, Sun Yat-sen University
2019-2023
OBJECTIVE Tribbles 3 (TRB3) is associated with insulin resistance, an important trigger in the development of diabetic cardiomyopathy (DCM). We sought to determine whether TRB3 plays a major role modulating DCM and mechanisms involved. RESEARCH DESIGN AND METHODS The type 2 rat model was induced by high-fat diet low-dose streptozotocin. evaluated characteristics serial echocardiography metabolite tests, Western blot analysis for expression, histopathologic analyses cardiomyocyte density,...
Abstract Ferroptosis is caused by lipid peroxidation and iron accumulation can cause cell death. Abnormally expressed transporters are involved in ferroptosis a variety of diseases. ZRT/IRT-like protein 14 (ZIP14) transport that mediate cellular uptake iron, zinc, manganese. Herein, we have tested the hypothesis divalent metal transporter ZIP14 initiation diabetic nephropathy (DN). DN was induced 8-week-old male rats streptozotocin before analysis degree renal tubular injury. In addition, an...
Cell-free heme (CFH) and hemoglobin (Hb) have emerged as distinct mediators of acute injury characterized by inflammation microcirculatory dysfunction in hemolytic conditions critical illness. Several reports shown changes Hb CFH specific pathophysiological settings. Using PBS, plasma from patients with sickle cell disease, respiratory distress syndrome (ARDS) supernatants red cells units, we found that commonly used assays commercially available kits do not distinguish between Hb....
Objectives The influence of left ventricular hypertrophy (LVH) on synchronicity, and the prevalence dyssynchrony in hypertensive patients with LVH are unknown. purpose this study was to determine synchronicity subjects. Method Tissue Doppler imaging (TDI) performed 115 30 control individuals. Hypertensive were divided into a group non-LVH according mass index (LVMI). Diastolic systolic asynchrony determined by measuring maximal differences time peak myocardial contraction (Ts-max) early...
Low serum testosterone level is associated with aging-related vascular stiffness, but the underlying mechanism unclear. The Growth arrest-specific protein 6 (Gas6) /Axl pathway has been proved to play important roles in cell senescence. In this study, we intend explore whether Gas6/Axl involved effect of on aging amelioration. Vascular models wild type and Axl-/- mice were established by natural aging. Mice these two gene types randomized into young group, group undecanoate (TU) treatment...
Abstract Diabetic nephropathy (DN) is a chronic inflammatory disease triggered by disordered metabolism. Recent studies suggested that protein tyrosine phosphatase non‐receptor type 2 (PTPN2) could ameliorate metabolic disorders and suppress responses. This study investigated PTPN2's role in modulating DN the possible cellular mechanisms involved. In mouse model combining hyperglycaemia hypercholesterolaemia (streptozotocin diabetic, ApoE ‐/‐ mice), mice showed severe insulin resistance,...
Wuhua yellow chicken (WHYC) is an important traditional yellow-feathered from China, which characterized by its white tail feathers, flight and strong disease resistance. However, the genomic basis of these unique traits associated with WHYC poorly understood. In this study, whole-genome resequencing was performed average coverage 20.77-fold to investigate heritable variation identify selection signals in WHYC. Reads were mapped onto reference genome (Galgal5) a 85.95%. After quality...
Sphingosine-1-phosphate (S1P), a bioactive lipid, is generally increased in human non-small cell lung cancer (NSCLC). Evidence has shown that the levels of enzymes S1P metabolism were associated with clinical outcomes patients NSCLC. Nevertheless, roles mRNA expression major (SPHK1, SPHK2 and SGPL1) for predicting NSCLC have not been determined."The Kaplan-Meier plotter" (the KM plotter) an online database which contains gene data 1,928 patients. In this study, we analyzed relationship...
Several studies have shown arterial stiffness changes associated with coronary artery disease (CAD). Recently, statins were reported to improve stiffness. The aim of the study was evaluate effect atorvastatin on in CAD patients using pulse wave velocity (PWV).We evaluated 63 hyperlipemia and CAD. Forty-three given 10mg daily 20 assigned a low-fat diet. Carotid-femoral PWV (PWV-CF), carotid-radial (PWV-CR) carotid-distal (PWV-CD) measured all patients.Compared baseline, PWV-CF, PWV-CR PWV-CD...
BackgroundThe CHADS2/CHA2DS2-VASc scores are used to predict thrombo-embolic/stroke in patients with nonvalvular atrial fibrillation (AF). Nevertheless, limited data available regarding the association between these risk stratification for stroke and left (LA) remodeling status of AF patients. The purpose this study was explore LA assessed quantificationally by echocardiography MethodsOne hundred were divided into 3 groups based on CHA2DS2-VASc/CHADS2 score: score 0 (low risk), 1 (moderate...
Using a rat (Lewis-Wistar Furth) abdominal heterotopic transplantation model, we reported previously that the expression of cyclooxygenase (COX)-2 is increased in parallel with nitric oxide synthase (NOS)-2 during cardiac allograft rejection.To investigate effects COX-2 inhibition this recipients were treated orally (PO) 5 mg/kg per day tetra substituted furanone selective inhibitor 5,5-dimethyl-3-(3 fluorophenyl)-4-(4 methylsulfonal) phenyl-2 (5H)-furanone (DFU) 1% methyl cellulose...
Introduction: Excessive daytime sleepiness (EDS) is one of the common and burdensome non-motor symptoms Parkinson's disease (PD). However, underlying neuropathology mechanism in PD patients with EDS remains unclear. The present study aims to delineate potential locations structural alteration subcortical regions early-stage drug naïve EDS. Methods: had 252 92 matched healthy controls (HC). was estimated Epworth scale, a cutoff 10. Ultimately, 59 were considered as (PD-EDS). remaining 193...
Inherited deficiency of phosphomannomutase 2 (PMM2) (aka PMM2-CDG) is the most common congenital disorders glycosylation (CDG) and has no cure. With debilitating morbidity significant mortality, it imperative to explore novel, safe, effective therapies for disease. Our Proof-of-Concept study showed that AAV9-
Circulating levels of microRNA-221 and 222 (miR-221/222) in patients with coronary artery disease (CAD) are elevated, yet the relationship between circulating miR-221/222 severity lesions acute syndrome (ACS) remains unknown. In this study, relative expression ACS (n = 267) controls 71) were compared by real-time fluorescence quantitative-polymerase chain reaction (RT-qPCR). The group was further divided into unstable angina pectoris (UA) 191) myocardial infarction (AMI) 76). Significant...
<i>Objectives:</i> Changes in connexins and calpains of the myocardial sleeve pulmonary vein left atrium were investigated chronic atrial fibrillation (AF) animal models. <i>Background:</i> There are no reports changes calpain system where AF is initiated. <i>Methods:</i> An model was prepared by rapid pacing right for 8 weeks. Histological veins analyzed Masson trichrome staining, mRNA as well protein expression measured real-time fluorescence...