A5024329926- Functional Brain Connectivity Studies
- Mental Health Research Topics
- Dementia and Cognitive Impairment Research
- Sleep and related disorders
- Lung Cancer Diagnosis and Treatment
- Sleep and Wakefulness Research
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Alzheimer's disease research and treatments
- Biblical Studies and Interpretation
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gut microbiota and health
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Folklore, Mythology, and Literature Studies
- Bioinformatics and Genomic Networks
- EEG and Brain-Computer Interfaces
- Blood Pressure and Hypertension Studies
- Osteomyelitis and Bone Disorders Research
- Lung Cancer Research Studies
- Historical and Linguistic Studies
- Parkinson's Disease Mechanisms and Treatments
- Spondyloarthritis Studies and Treatments
Xuzhou Children Hospital
2025
Chengdu Second People's Hospital
2018-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Army Medical University
2013-2025
Peking Union Medical College Hospital
2020-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024-2025
Institute of Laboratory Animal Science
2025
Chongqing Medical University
2024
Chengdu Medical College
2024
Anhui Medical University
2010-2023
Circular RNAs (circRNAs), highly expressed in the central nervous system, are involved various regulatory processes and implicated some pathophysiology. However, potential role of circRNAs psychiatric diseases, particularly major depressive disorder (MDD), remains largely unknown. Here, we demonstrated that circular RNA DYM (circDYM) levels were significantly decreased both peripheral blood patients with MDD two depressive-like mouse models: chronic unpredictable stress (CUS)...
Background Acute necrotizing pancreatitis (NP), a severe form of acute (AP), has higher mortality and worse outcome than non-necrotizing (non-NP). Infected NP is devastating subgroup NP. To date neither nor infected robust prediction strategies, which may delay early recognition timely intervention. Recent studies revealed correlations between disturbed gut microbiota AP severity. Some features intestinal have the potential to become biomarkers for prediction. Methods We performed 16S rRNA...
Background: Central lymph node metastasis (CLNM) occurs frequently in patients with papillary thyroid cancer (PTC), but performing prophylactic central dissection is still controversial. There are no reliable models for predicting CLNM. This study aimed to develop predictive CLNM by machine learning (ML) algorithms. Methods: Patients PTC who underwent initial resection at our hospital between January 2018 and December 2019 were enrolled. A total of 22 variables, including clinical...
Acute respiratory distress syndrome (ARDS) is the most common cause of organ failure in acute pancreatitis (AP) patients, which associated with high mortality. Specific changes gut microbiota have been shown to influence progression pancreatitis. We aimed determine whether early alterations related and could predict ARDS occurrence AP patients.In this study, we performed 16S rRNA sequencing analysis 65 patients 20 healthy volunteers. The were further divided into two groups: 26 AP-ARDS 39...
Abstract Background The protective effect of vitamin C as an antioxidant against asthma in adults remains controversial. This study used observational and Mendelian randomization (MR) analysis to investigate the association between adult serum levels. Methods Using information from National Health Nutrition Examination Survey (NHANES) 2003–2006, we carried out study. A multivariate logistic regression model was employed examine connection We inverse-variance weighted (IVW) method MR primary...
Abstract In this study, we aimed to investigate the intrinsic hippocampal functional connectivity (FC) network and its relationship with prospective memory in patients breast cancer suffering from chemotherapy-induced cognitive impairment (CICI). Thirty-four before after adjuvant chemotherapy (CB CC, respectively) 31 age- education-matched cognitively normal (CN) women were recruited subjected a task resting-state magnetic resonance imaging scan. Seed-based analysis was used compare FC...
Affective disorders, such as anxiety and depression, are common comorbidities associated with chronic insomnia disorder (CID). However, the underlying neural mechanisms of these still not clear. The present study is aimed at investigating structural changes in amygdala CID patients using surface-based shape analysis. A total 65 medication-naive 55 healthy controls (HCs) matched for age, sex, years education were enrolled this subjected to magnetic resonance imaging (MRI). Oxford Centre...
Insomnia and depression are highly comorbid symptoms in both primary insomnia (PI) major depressive disorder (MDD). In the current study, we aimed at exploring homogeneous heterogeneous brain structure alteration PI MDD patients. Sixty-five patients 67 matched were recruited underwent a structural MRI scan. The subjects sub-divided into four groups, namely with higher or lower insomnia, severe depression. A general linear model was employed to explore changes cortical thickness volume as...
Many studies define obesity based on body mass index (BMI) and explore its relationship with adult asthma. However, BMI only considers height weight, ignoring other factors such as fat, which may have a greater impact health. We investigated the between fat distribution asthma using both cross-sectional study bidirectional Mendelian randomization (MR) analysis.
Background Mental syndromes such as anxiety and depression are common comorbidities in patients with chronic insomnia disorder (CID). The locus coeruleus noradrenergic (LC-NE) system is considered to be crucial for modulation of emotion sleep/wake cycle. LC-NE also a critical mediator the stress-induced anxiety. However, whether contributes underlying mechanism linking these remain unclear. This study aimed investigate alterations its relationship symptoms. Materials Methods Seventy CID 63...
Hypertriglyceridemia-associated acute pancreatitis (HTGAP) is linked with increased severity and morbidity. Intestinal flora plays an important role in the progression of (AP). However, pathogenetic association between gut microbiota HTGAP remains unknown. In this study, we enrolled 30 patients AP that evoked by other causes. The V3-V4 regions 16S rRNA sequences were analyzed. Clinical characteristics, microbial diversity, taxonomic profile, microbiome composition, microbiological phenotype,...
To investigate chemotherapy dosage-related cognitive impairment and its neural mechanisms in breast cancer (BC) patients. Twenty-eight patients after each cycle matched 29 healthy control subjects underwent structural magnetic resonance imaging. Voxel-based morphometry analysis was performed to compare group differences the gray matter for whole brain. Furthermore, mediation conducted explore role of brain structures impairment. BC chemotherapy. The results revealed that density left...
Both geriatric depression and mild cognitive impairment confer an increased risk for the development of dementia. The mechanisms underlying in patients remain controversial. present study aimed to explore association decline with vascular risk, white matter hyperintensity (WMH) burden hippocampal volume both remitted (RGD) subjects amnestic (aMCI) subjects. Forty-one RGD subjects, 51 aMCI 64 healthy elderly underwent multimodal MRI scans neuropsychological tests at baseline a 35-month...
// Baoyu Yuan 1 , Jiu Chen Liang Gong Hao Shu Wenxiang Liao Zan Wang Duan Liu Chunming Xie and Zhijun Zhang Department of Neurology, ZhongDa Hospital, Neuropsychiatric Institute, Medical School Southeast University, Nanjing, PR China Correspondence to: Zhang, email: Xie, Keywords : amnestic mild cognitive impairment (aMCI), executive function (EF), episodic memory (EM), regional homogeneity (ReHo), functional magnetic resonance imaging (fMRI), Pathology Section Received January 25, 2016...
Insomnia is a common comorbidity symptom in patients with major depressive disorder (MDD). However, the brain functional alteration MDD higher level insomnia (MDD-HI) and lower (MDD-LI) remains unclear. Here, we investigated association of global connectivity density (gFCD) MDD. A total 148 participants were recruited underwent resting-state magnetic resonance imaging. voxel-wise analysis covariance was employed to explore group differences gFCD among MDD-HI, MDD-LI healthy control (HC)...
Background: Lymph node metastasis (LNM) is difficult to precisely predict before surgery in patients with early-T-stage non-small cell lung cancer (NSCLC). This study aimed develop machine learning (ML)-based predictive models for LNM. Methods: Clinical characteristics and imaging features were retrospectively collected from 1102 NSCLC ≤ 2 cm patients. A total of 23 variables included LNM by multiple ML algorithms. The evaluated the receiver operating characteristic (ROC) curve performance...
<title>Abstract</title> Plastic bronchitis (PB) is a severe complication of <italic>Mycoplasma pneumoniae</italic> pneumonia (MPP). However, clinical factors predicting the occurrence PB in MPP children have rarely been studied. The goal this study was to establish nomogram model predict early children. We retrospectively analyzed data from who underwent electronic bronchoscopy at Affiliated Xuzhou Children's Hospital Medical University between January 2023 and June 2024. Least absolute...