A5100446544- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Mental Health Research Topics
- Sleep and Wakefulness Research
- Advanced MRI Techniques and Applications
- Sleep and related disorders
- EEG and Brain-Computer Interfaces
- Multisensory perception and integration
- Dementia and Cognitive Impairment Research
- Face Recognition and Perception
- Genetics and Neurodevelopmental Disorders
- Memory and Neural Mechanisms
- Schizophrenia research and treatment
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Autism Spectrum Disorder Research
- Neuroscience and Music Perception
- Body Image and Dysmorphia Studies
- Bipolar Disorder and Treatment
- Acoustic Wave Resonator Technologies
- MRI in cancer diagnosis
- Atomic and Subatomic Physics Research
Shanghai Center for Brain Science and Brain-Inspired Technology
2022-2025
Fudan University
2022-2025
Huashan Hospital
2024-2025
Chengdu Second People's Hospital
2019-2024
Shanghai Institute for Science of Science
2022-2024
Massachusetts General Hospital
2024
Athinoula A. Martinos Center for Biomedical Imaging
2024
Harvard University
2024
Ludwig-Maximilians-Universität München
2018-2023
Guangzhou Medical University
2017-2021
Abstract Food preferences significantly influence dietary choices, yet understanding natural patterns in populations remains limited. Here we identifiy four subtypes by applying data-driven approaches to food-liking data from 181,990 UK Biobank participants: ‘starch-free or reduced-starch’ (subtype 1), ‘vegetarian’ 2), ‘high protein and low fiber’ 3) ‘balanced’ 4). These varied diverse brain health domains. The individuals with a balanced diet demonstrated better mental superior cognitive...
Observers can learn the likely locations of salient distractors in visual search, reducing their potential to cause interference. Although there is agreement that this involves positional suppression distractor location(s), it contentious at which stage operates: search-guiding priority map, integrates feature-contrast signals (e.g., generated by a red among green or diamond circular items) across dimensions, distractor-defining dimension. On latter, dimension-based account (Sauter,...
Abstract Observers can learn locations where salient distractors appear frequently to reduce potential interference—an effect attributed better suppression of at frequent locations. But how distractor is implemented in the visual cortex and within frontoparietal attention networks remains unclear. We used fMRI a regional distractor-location learning paradigm with two types defined either same (orientation) or different (color) dimension target investigate this issue. results showed that BOLD...
Background Mental syndromes such as anxiety and depression are common comorbidities in patients with chronic insomnia disorder (CID). The locus coeruleus noradrenergic (LC-NE) system is considered to be crucial for modulation of emotion sleep/wake cycle. LC-NE also a critical mediator the stress-induced anxiety. However, whether contributes underlying mechanism linking these remain unclear. This study aimed investigate alterations its relationship symptoms. Materials Methods Seventy CID 63...
Insomnia is a common comorbidity symptom in patients with major depressive disorder (MDD). However, the brain functional alteration MDD higher level insomnia (MDD-HI) and lower (MDD-LI) remains unclear. Here, we investigated association of global connectivity density (gFCD) MDD. A total 148 participants were recruited underwent resting-state magnetic resonance imaging. voxel-wise analysis covariance was employed to explore group differences gFCD among MDD-HI, MDD-LI healthy control (HC)...
Abstract Frontostriatal circuits dysfunction has been implicated in the etiology and psychopathology of patients with schizophrenia (SZ). However, few studies have investigated SZ‐related functional connectivity (FC) alterations discrete frontostriatal their relationship pathopsychology first‐episode (FESZ). The goal this study was to identify dysfunctions that are associated key features FESZ. To end, a case–control, cross‐sectional conducted, wherein resting‐state (RS) magnetic resonance...
Salient but task-irrelevant distractors interfere less with visual search when they appear in a display region where have appeared more frequently the past ("distractor-location probability cuing"). This effect could reflect (re-)distribution of global, limited attentional "inhibition resource." Accordingly, changing frequency distractor appearance one should also affect magnitude interference generated by different region. Alternatively, distractor-location learning may local response...
Abstract The ascending arousal system plays a crucial role in individuals' consciousness. Recently, advanced functional magnetic resonance imaging (fMRI) has made it possible to investigate the network (AAN) vivo. However, of AAN neuropathology human insomnia remains unclear. Our study aimed explore alterations and its connections with cortical networks chronic disorder (CID). Resting‐state fMRI data were acquired from 60 patients CID good sleeper controls (GSCs). Changes brain's...
Under a "cocktail-party" listening condition with multiple-people talking, compared to healthy people, people schizophrenia benefit less from the use of visual-speech (lipreading) priming (VSP) cues improve speech recognition. The neural mechanisms underlying unmasking effect VSP remain unknown. This study investigated brain substrates in listeners and schizophrenia-induced changes substrates. Using functional magnetic resonance imaging, activation connectivity for contrasts vs. visual...
Abstract A salient distractor interferes less with visual search if it appears at a location where is likely to occur, referred as distractor‐location probability cueing. Conversely, the current target same on preceding trial, impeded. While these two location‐specific “suppression” effects reflect long‐term, statistically learnt and short‐term, inter‐trial adaptations of system distractors, unclear what stage(s) processing they arise. Here, we adopted additional‐singleton paradigm examined...
Depression is a common comorbid symptom in patients with chronic insomnia disorder (CID). Previous neuroimaging studies found that the orbital frontal cortex (OFC) might be core brain region linking and depression. Here, we used machine learning approach to differentiate CID depressive symptoms from without based on OFC functional connectivity. Seventy were recruited subdivided into high (CID-HD) low (CID-LD) groups. The connectivity (FC) network was constructed using altered structure of as...
High-resolution awake mouse functional magnetic resonance imaging (fMRI) remains challenging despite extensive efforts to address motion-induced artifacts and stress. This study introduces an implantable radio frequency (RF) surface coil design that minimizes image distortion caused by the air/tissue interface of brains while simultaneously serving as a headpost for fixation during scanning. Furthermore, this provides thorough acclimation method used accustom animals MRI environment...
Chronic insomnia disorder (CID) is frequently comorbid with depression, and both conditions are believed to involve disruptions in the reward network. However, potential effects of genetic polymorphisms modulating this network remain largely unexplored.
High-resolution awake mouse fMRI remains challenging despite extensive efforts to address motion-induced artifacts and stress. This study introduces an implantable radiofrequency (RF) surface coil design that minimizes image distortion caused by the air/tissue interface of brains while simultaneously serving as a headpost for fixation during scanning. Using 14T scanner, high-resolution enabled brain-wide functional mapping visual vibrissa stimulation at 100x100x200µm resolution with 2s per...
Abstract Sex and apolipoprotein E (APOE) genotype have been shown to influence the risk progression of Alzheimer’s disease (AD). However, impact these factors on functional connectivity entorhinal cortex (ERC) in clinically unpaired older adults (CUOA) with amyloid-β (Aβ +) pathology remains unclear. A total 1022 cognitively normal Aβ + (603 females 586 APOE ε4 from Anti-Amyloid Treatment Asymptomatic (A4) study were included this study. The 2 × (gender, genotypes) analysis covariance was...
Working memory (WM) deficit is considered a core feature and cognitive biomarker in patients with schizophrenia. Several studies have reported prominent object WM deficits schizophrenia, suggesting that visual these extends to non-spatial domains. However, whether similarly affected remains unclear.This study primarily aimed identify the processing of first-episode schizophrenia.The included 36 schizophrenia 35 healthy controls. Visual capacity, including face house was assessed by means...