A5022331160- Sleep and related disorders
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Sleep and Wakefulness Research
- Nuclear Receptors and Signaling
- Healthcare professionals’ stress and burnout
- Job Satisfaction and Organizational Behavior
- COVID-19 and Mental Health
- Functional Brain Connectivity Studies
- Resilience and Mental Health
- Acupuncture Treatment Research Studies
- Mental Health Research Topics
- Advanced Neuroimaging Techniques and Applications
- Health, psychology, and well-being
- Stroke Rehabilitation and Recovery
- Healthcare and Venom Research
- Traditional Chinese Medicine Studies
- Posttraumatic Stress Disorder Research
- Endometriosis Research and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Restless Legs Syndrome Research
- Dietary Effects on Health
- Inflammasome and immune disorders
- Health Promotion and Cardiovascular Prevention
- Digital Mental Health Interventions
Chengdu University of Traditional Chinese Medicine
2018-2024
Shaoyang University
2020-2022
Weatherford College
2020
Nanchang University
2019-2020
Knowledge Unlatched (Germany)
2018
University of South China
2010-2017
Chengdu University
2014-2015
CAE (Canada)
2007
Vascular smooth muscle cells (VSMCs) were prepared from thoracic aortas of male Sprague-Dawley rats by the explant method to observe VSMC proliferation via phosphoinositide 3 kinase (PI3K)/Akt signaling transduction pathway induced apelin-13. Expression PI3K, phospho-PI3K, phospho-Akt, ERK1/2, phospho-ERK1/2 and cyclin D1 was detected western blot analysis. Results showed that apelin-13 promoted expression phospho-PI3K phospho-Akt in dose- timedependent manner. PI3K inhibitor LY294002...
To examine relationships between psychological capital, work engagement and organisational citizenship behaviour among nurses.Psychological are all positive variables associated with work. Clarifying the relationship can help nursing managers implement tailored effective intervention strategies to improve individual performance quality of care.A quantitative cross-sectional study was designed.The carried out from June 2021 September in Sichuan Province, China. A total 606 nurses working at...
Apelin is highly expressed in rat left ventricular hypertrophy Sprague Dawley models, and it plays a crucial role the cardiovascular system. The aim this study was to clarify whether apelin-13 promotes H9c2 cardiomyocytes investigate its underlying mechanism. cardiomyocyte observed by measuring diameter, volume, protein content of cells. activation autophagy evaluated observing morphology autophagosomes transmission electron microscopy, subcellular localization LC3 light detecting...
Affective disorders, such as anxiety and depression, are common comorbidities associated with chronic insomnia disorder (CID). However, the underlying neural mechanisms of these still not clear. The present study is aimed at investigating structural changes in amygdala CID patients using surface-based shape analysis. A total 65 medication-naive 55 healthy controls (HCs) matched for age, sex, years education were enrolled this subjected to magnetic resonance imaging (MRI). Oxford Centre...
Insomnia and depression are highly comorbid symptoms in both primary insomnia (PI) major depressive disorder (MDD). In the current study, we aimed at exploring homogeneous heterogeneous brain structure alteration PI MDD patients. Sixty-five patients 67 matched were recruited underwent a structural MRI scan. The subjects sub-divided into four groups, namely with higher or lower insomnia, severe depression. A general linear model was employed to explore changes cortical thickness volume as...
Compassion fatigue has emerged as a detrimental consequence of experiencing work-related stress among psychiatric nurses, and affected the job performance, emotional physical health nurses. However, researches on Chinese nurses' compassion are dearth. This cross-sectional study aimed to investigate prevalence factors nurses.All participants completed demographic questionnaire version Professional Quality Life Scale (ProQOL-CN). One-way ANOVA, t-tests, Levene test multiple linear regression...
Abstract Background Nurses’ organizational citizenship behavior, a spontaneous “altruistic work behavior”, may be affected by psychological capital and commitment, but its mechanism is not clear. The aim of this study was to investigate the characteristics distribution capital, commitment behavior among nurses during COVID-19 epidemic, explore mediating role in behavior. Methods A cross-sectional survey conducted 746 from 6 designated hospitals for treatment China. Descriptive statistics,...
This study is designed to investigate whether APJ receptor acts as a sensor in static pressure-induced cardiomyocyte hypertrophy and the mechanism of PI3K-autophagy pathway. The left ventricular rat model was established by coarctation abdominal aorta. H9c2 cardiomyocytes were cultured presence pressure which given custom-made incubator. results revealed that expression apelin/APJ system, PI3K, Akt their phosphorylation significantly increased operation group. Static up-regulated expression,...
This study aims to investigate the levels of organizational commitment and work engagement among clinical nurses in tertiary hospitals explore relationship between them.The nursing literature supports idea that plays an important role positively influencing job performance. However, remains unclear.This was a cross-sectional study. A convenience sample (n = 621) selected from five Sichuan Province China. Survey instruments included general information questionnaire about engagement....
Apelin, an endogenous ligand for apelin receptor (APJ), is reported to be involved in cardiomyocyte hypertrophy. In this study, we explored the mechanism of hypertrophy induced by apelin-13/APJ system. Left ventricular (LVH) rat model was established constricting abdominal aorta. Western blots were used protein expression LVH rats and cultured H9c2 cardiomyocytes. Transmission electron microscopy (TEM) monitor morphological features cells. addition, diameter volume cells detected Scepter™...
Gender differences in hippocampal and parahippocampal gyrus (HIP/PHG) volumes have been reported sleep disorders. Therefore, this study investigated the moderating effect of gender on relationship between chronic insomnia disorder (CID) HIP/PHG functional connectivity (FC) network.For study, 110 patients diagnosed with CID (43 men 67 women) 60 matched good control (GSC) (22 38 were recruited. These participants underwent resting-state magnetic resonance imaging scans, after which a 2 ×...
Primary insomnia (PI) is one of the most common complaints among general population. Both non-pharmacological and pharmacological therapies have proven effective in treating primary insomnia. However, underlying mechanism treatment remains unclear, no studies compared mechanisms different treatments. In this study, we investigated gray matter volume (GMV) resting-state functional connectivity (rsFC) changes following both treatments patients with PI. A total 67 PI were randomized into...
Abstract A recent study suggests that voltage‐dependent anion channel (VDAC) oligomer pores promote mitochondrial outer membrane permeabilization and allow DNA (mtDNA) to be released into the cytosol in live cells. It challenges notion only occurs apoptotic cells via BAX/BAK macropores. Cytosolic mtDNA activates cyclic GMP–AMP synthase (cGAS)–stimulator of IFN gene (STING) pathway triggers type I interferon (IFN) response thereafter, which ultimately causes systemic lupus erythematosus....
The Notch signalling pathway in the mammalian ovary regulates granulosa cell proliferation. However, effects of on steroidogenesis are unclear. In this study we cultured mouse ovarian cells from preantral follicles invitro and observed effect through overexpression, knockdown inhibition signalling. Activation decreased progesterone oestrogen secretion. contrast, increased production oestrogen. Expression genes for steroidogenic-related enzymes, including 3β-hydroxysteroid dehydrogenase, p450...
Abstract Prolyl oligopeptidase (POP), one of the most widely distributed serine endopeptidases, is highly expressed in ovaries. However, physiological role POP ovaries not clear. In this study, we investigated significance corpus luteum. Murine luteal cells were cultured vitro and treated with a selective inhibitor, (2 S )‐1[[(2 )‐1‐(1‐oxo‐4‐phenylbutyl)‐2‐pyrrolidinyl carbonyl]‐2‐pyrrolidinecarbonitrile (KYP‐2047). We found that KYP‐2047 treatment decreased progesterone secretion. contrast,...