A5060333167- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Circular RNAs in diseases
- Cutaneous Melanoma Detection and Management
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Winter Sports Injuries and Performance
- Nonmelanoma Skin Cancer Studies
- RNA Research and Splicing
- Tryptophan and brain disorders
- Autophagy in Disease and Therapy
- Spine and Intervertebral Disc Pathology
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Musculoskeletal pain and rehabilitation
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Medical Imaging and Analysis
- Adventure Sports and Sensation Seeking
Affiliated Hospital of Nantong University
2023-2025
Nantong University
2023-2025
Zhejiang University
2022-2025
Guangdong Academy of Medical Sciences
2022-2025
Guangdong Provincial People's Hospital
2022-2025
Hangzhou Medical College
2023-2025
Nanjing Tech University
2022-2025
Southern Medical University
2024-2025
Sir Run Run Shaw Hospital
2025
University of California, Los Angeles
2003-2024
Circular RNAs (circRNAs) are highly expressed in the CNS and regulate physiological pathophysiological processes. However, potential role of circRNAs stroke remains largely unknown. Here, we show that circRNA DLGAP4 (circDLGAP4) functions as an endogenous microRNA-143 (miR-143) sponge to inhibit miR-143 activity, resulting inhibition homologous E6-AP C-terminal domain E3 ubiquitin protein ligase 1 expression. circDLGAP4 levels were significantly decreased plasma acute ischemic patients (13...
Circular RNAs (circRNAs) are highly expressed in the central nervous system and involved regulation of physiological pathophysiological processes. However, potential role circRNAs stroke remains largely unknown. Here, using a circRNA microarray, we showed that circular RNA Hectd1 (circHectd1) levels were significantly increased ischemic brain tissues transient middle cerebral artery occlusion (tMCAO) mouse models further validated this finding plasma samples from acute (AIS) patients....
Abstract Emerging evidence indicates that exosomes derived from gastric cancer cells enhance tumor migration and invasion through the modulation of microenvironment. However, it remains a major problem to detect cancer‐specific due technical biological challenges. Most methods reported could not achieve efficient detection tumor‐derived in background normal exosomes. Herein, label‐free electrochemical aptasensor is presented for specific This platform contains an anti‐CD63 antibody modified...
Circular RNAs are a subclass of noncoding in mammalian cells; however, whether these involved the regulation astrocyte activation is largely unknown. Here, we have shown that circular RNA HIPK2 (circHIPK2) functions as an endogenous microRNA-124 (MIR124-2HG) sponge to sequester MIR124-2HG and inhibit its activity, resulting increased sigma non-opioid intracellular receptor 1 (SIGMAR1/OPRS1) expression. Knockdown circHIPK2 expression significantly inhibited via autophagy endoplasmic reticulum...
Inflammasomes have been found to interact with the gut microbiota, and this effect is associated depression, but mechanisms underlying interaction not elucidated in detail.The locomotor activity of NLRP3 KO mice was significantly greater than that their WT littermates, while cohousing transplantation microbiota avoid effects on general at baseline. Meanwhile, alleviated CUS-induced depressive-like behaviors. The compositions were different terms relative abundance Firmicutes, Proteobacteria,...
Exosomes are membrane nanovesicles carrying molecular information that may reflect the biological and genetic characteristics of their parent cells.
Aptamers are short single-stranded DNA or RNA oligonucleotides and can be selected from synthetic combinatorial libraries in vitro. They have a high binding affinity specificity for their targets. Agarose gels, nitrocellulose membranes, adsorptive microplates often used as carriers to immobilize targets the SELEX (systematic evolution of ligands by exponential enrichment) process, but subsequent separation step is tedious time-consuming. Therefore, we magnetic nanoparticles (MNPs) target,...
Circular RNAs (circRNAs), highly expressed in the central nervous system, are involved various regulatory processes and implicated some pathophysiology. However, potential role of circRNAs psychiatric diseases, particularly major depressive disorder (MDD), remains largely unknown. Here, we demonstrated that circular RNA DYM (circDYM) levels were significantly decreased both peripheral blood patients with MDD two depressive-like mouse models: chronic unpredictable stress (CUS)...
N6-methyladenosine (m6A) is the most abundant epigenetic modification in eukaryotic messenger RNAs and essential for multiple RNA processing events physiological pathological processes. However, precisely how m6A methylation involved major depressive disorder (MDD) not fully understood.Circular STAG1 (circSTAG1) was screened from hippocampus of chronic unpredictable stress-treated mice using high-throughput sequencing. Microinjection circSTAG1 lentivirus into mouse used to observe role...
The broad-spectrum antineoplastic drug doxorubicin (DOX) has one of the most serious chronic side effects on heart, dilated cardiomyopathy, but precise molecular mechanisms underlying disease progression subsequent to long latency periods remain puzzling. Here, we established a model DOX-induced cardiomyopathy. In cardiac cytology exploration, found that differentially expressed genes in KEGG signaling pathway enrichment provided novel complex network mTOR bridging autophagy and oxidative...
Non-alcoholic fatty liver disease (NAFLD) encompasses hepatic steatosis, non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. It is the primary cause of chronic disorders, with a high prevalence but no approved treatment. Therefore, it indispensable to find trustworthy therapy for NAFLD. Recently, mounting evidence illustrates that Sirtuin 1 (SIRT1) strongly associated SIRT1 activation or overexpression attenuate NAFLD, while deficiency aggravates Besides,...
Abstract Background Papillary thyroid carcinoma (PTC) is the most common malignant endocrine tumour, and its incidence prevalence are increasing considerably. Cellular heterogeneity in tumour microenvironment important for PTC prognosis. Spatial transcriptomics a powerful technique cellular study. Methods In conjunction with clinical pathologist identification method, spatial was employed to characterise location RNA profiles of PTC‐associated cells within tissue sections. The RNA‐clinical...
Epilepsy is one of the most common chronic neurological disorders which provoke progressive neuronal degeneration. Endoplasmic reticulum (ER) stress has recently been recognized as pivotal etiological factors contributing to epilepsy-induced damage. However, specific contribution epilepsy made ER remains largely elusive. Here we use pentylenetetrazole (PTZ) kindling, a model, identify nitric oxide synthase (nNOS) signaling molecule triggering PTZ kindling and oxidative By genetic deletion...
Chronic stress has been implicated in many types of neurodegenerative diseases, such as Alzheimer's disease (AD). In our previous study, we demonstrated that chronic restraint (CRS) induced reactive oxygen species (ROS) overproduction and oxidative damage the frontal cortex hippocampus mice. present investigated effects CRS (over a period 8 weeks) on learning memory impairment endoplasmic reticulum (ER) male The Morris water maze was used to investigate impairment. Immunohistochemistry...
Forkhead box transcription factor M1 ( FOXM 1) is a proliferation‐associated involved in tumorigenesis through transcriptional regulation of its target genes various cells, including dendritic cells DC s). Although previous work has shown that 1 enhances maturation response to house dust mite allergens, it not known whether affects the context tumor‐specific immunity. In this study, we examined central role regulating bone marrow‐derived cell BMDC ) phenotypes and function pancreatic cancer...