A5088662603- Circular RNAs in diseases
- MicroRNA in disease regulation
- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Extracellular vesicles in disease
- RNA modifications and cancer
- Molecular Sensors and Ion Detection
- RNA Research and Splicing
- Photodynamic Therapy Research Studies
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Hemoglobin structure and function
- Lipid metabolism and biosynthesis
- Fibromyalgia and Chronic Fatigue Syndrome Research
- ATP Synthase and ATPases Research
- Macrophage Migration Inhibitory Factor
- Curcumin's Biomedical Applications
- Diet and metabolism studies
- Biotin and Related Studies
- Cancer-related molecular mechanisms research
- Protein Structure and Dynamics
- Genetics and Neurodevelopmental Disorders
Southeast University
2019-2025
Nanjing Normal University
2025
Zhongda Hospital Southeast University
2019
Background: Stroke is a leading cause of adult disability that can severely compromise the quality life patients, yet no effective medication currently exists to accelerate rehabilitation. A variety circular RNA (circRNA) molecules are known function in ischemic brain injury. Lentivirus-based expression systems have been widely used basic studies circRNAs, but safety issues with such delivery limited exploration potential therapeutic roles for circRNAs. Methods: Circular SCMH1 (circSCMH1)...
Abstract Major depressive disorder (MDD) is the most prevalent psychiatric worldwide and severely limits psychosocial function quality of life, but no effective medication currently available. Circular RNAs (circRNAs) have been revealed to participate in MDD pathological process. Targeted delivery circRNAs without blood‐brain barrier (BBB) restriction for remission represents a promising approach antidepressant therapy. In this study, RVG‐circDYM‐extracellular vesicles (RVG‐circDYM‐EVs) were...
Neuroinflammation is acknowledged as a pivotal pathological event after cerebral ischemia. However, there limited knowledge of the molecular and spatial characteristics nonneuronal cells, well interactions between cell types in ischemic brain. Here, we used transcriptomics to study hemisphere mice stroke sequenced transcriptomes 19,777 spots, allowing us both visualize transcriptional landscape within tissue identify gene expression profiles linked specific histologic entities. Cell...
N6-methyladenosine (m6A) is the most abundant epigenetic modification in eukaryotic messenger RNAs and essential for multiple RNA processing events physiological pathological processes. However, precisely how m6A methylation involved major depressive disorder (MDD) not fully understood.Circular STAG1 (circSTAG1) was screened from hippocampus of chronic unpredictable stress-treated mice using high-throughput sequencing. Microinjection circSTAG1 lentivirus into mouse used to observe role...
Background and Purpose— Circular RNAs (CircRNAs) show promise as stroke biomarkers because of their participation in various pathophysiological processes associated with acute ischemic (AIS) stability peripheral blood. Methods— A circRNA microarray was used to identify differentially expressed circulating circRNAs a discovery cohort (3 versus 3). Validation (36 36) replication (200 100) were performed independent cohorts by quantitative polymerase chain reaction. Platelets, lymphocytes,...
A chemicobiology toolbox for type I and II photodynamic therapy.
Photodynamic therapy (PDT) is a promising noninvasive treatment that has drawn great attention. However, the hypoxic environment in tumors seriously limits therapeutic effect of oxygen-dependent chemicals and PDT. Herein, versatile nanocomposite DF-BODIPY@ZIF-8 with oxygen-generating ability was developed based on zeolitic imidazolate framework-8 (ZIF-8) by loading near-infrared photosensitizer DF-BODIPY to overcome hypoxia-induced drug resistance cancer therapy. ZIF-8 can catalyze...
Ischemic stroke represents one of the leading cerebrovascular diseases with a high rate mortality and disability globally. To date, there are no effective clinical drugs available to improve long-term outcomes for post-stroke patients. A novel nucleic acid agent circSCMH1 which can promote sensorimotor function recovery in rodent nonhuman primate animal models has been found. However, still delivery challenges overcome its implementation. Besides, effects on cognitive functions remain...
Abstract RNA therapeutics have recently shown significant promise in treating a variety of diseases, including cancers, infectious and genetic disorders. However, their potential addressing neuropsychiatric disorders has been limited by the lack an efficient delivery system to central nervous (CNS). Here, novel nanoemulsion platform, perillyl alcohol nanoemulsions (PANEs) is introduced, designed for therapeutic circDYM brain alleviated depressive‐like behaviors. PANEs successfully...
Degenerative diseases are closely associated with protein phase transitions. Endoplasmic reticulum (ER), the primary site of synthesis, experiences homeostasis imbalance as key trigger transition. Effective tools to monitor ER microenvironment changes crucial for investigating behavior. In this work, we developed a set viscosity-sensitive probes based on dicyanomethylene-4H-pyran (namely, VisDCM probes) dual response fluorescence intensity and lifetime local viscosity changes. Computational...
The N6-methyladenosine (m6A) modification is the most prevalent of eukaryotic mRNAs and plays a crucial role in various physiological processes by regulating stability or function target mRNAs. Accumulating evidence has suggested that m6A methylation may be involved pathological process major depressive disorder (MDD), common neuropsychiatric with an unclear aetiology. Here, we found levels circular RNA HECW2 (circHECW2) were significantly increased plasma both MDD patients chronic...
Abstract Major depressive disorder (MDD) is a prevalent mental that significantly impacts social and psychological function, but no effective medication currently available. Circular RNAs (circRNAs) have been reported to participate in the pathogenesis of MDD which are envisioned as promising therapeutic targets. However, nonviral‐based delivery strategies targeting circRNA against not thoroughly investigated. Here, it identified circATF7IP upregulated plasma samples positively correlated...
Abstract In this study, a novel p ‐hydroxybenzylidene‐imidazolidone derivatives‐based probe CBX (abbreviation of the synthetic probe) is designed and synthesized for sensitive detection protamine. emits fluorescence at 569 nm large Stokes shift 114 observed. Since protamine can induce aggregation negatively charged CBX, shows excellent fluorescent response to Due stronger electrostatic interactions between heparin protamine, prefers unite with rather than after addition heparin, so decreases...