A5100704912- Advanced Polymer Synthesis and Characterization
- Advanced Semiconductor Detectors and Materials
- Semiconductor Quantum Structures and Devices
- Dendrimers and Hyperbranched Polymers
- biodegradable polymer synthesis and properties
- Polymer Surface Interaction Studies
- Synthetic Organic Chemistry Methods
- Chalcogenide Semiconductor Thin Films
- Infrared Target Detection Methodologies
- Spectroscopy and Laser Applications
- Click Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Conducting polymers and applications
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- Natural product bioactivities and synthesis
- Nanoplatforms for cancer theranostics
- Fuel Cells and Related Materials
- Bone Tissue Engineering Materials
- Phytochemistry and Biological Activities
- Photopolymerization techniques and applications
- Microfluidic and Capillary Electrophoresis Applications
- Crystallization and Solubility Studies
- Surface Modification and Superhydrophobicity
- Chemical Synthesis and Analysis
Fudan University
2016-2025
People's Liberation Army 401 Hospital
2014-2025
Second Affiliated Hospital of Zhejiang University
2021-2024
Zhejiang University of Science and Technology
2021-2024
Institute of Semiconductors
2015-2024
Chinese Academy of Sciences
2015-2024
Zhejiang University
2017-2024
Chongqing University of Posts and Telecommunications
2024
Third Xiangya Hospital
2024
Central South University
2013-2024
Polymer micelles are one of the most investigated nanocarriers for drug delivery; many have entered clinical trials and some in clinic use, but their delivery systems not yet shown expected high therapeutic efficacy clinics. Further understanding vivo behaviors, particularly how quickly by what mechanism polymer cleared (i.e., via or unimers) once injected, is key to solving this dilemma. Herein, we hope answer these questions clinically relevant polyethylene...
In this study, a multi-benzaldehyde functionalized poly(ethylene glycol) analogue, oxide-co-glycidol)-CHO (poly(EO-co-Gly)-CHO), was designed and synthesized for the first time, applied as cross-linker to develop an injectable hydrogel system. Simply mixing two aqueous precursor solutions of glycol chitosan (GC) poly(EO-co-Gly)-CHO led formation chemically cross-linked hydrogels under physiological conditions in situ. The cross-linking attributed Schiff's base reaction between amino groups...
Polymerization-induced self-assembly (PISA) was achieved by conducting an initiators for continuous activator regeneration atom transfer radical polymerization (ICAR ATRP) at low ppm of copper catalyst concentration. A poly(oligo(ethylene oxide) methyl ether methacrylate)50 (POEOMA50) macroinitiator and stabilizer synthesized aqueous ICAR ATRP using CuIICl2/tris(pyridin-2-ylmethyl)amine (TPMA) complex. Subsequently, the dispersion benzyl methacrylate (BnMA) in ethanol realized with a...
Abstract Oil spill disasters always occur accidentally, accompanied by the release of plenty crude oil that could spread quickly over a wide area, creating enormous damage to fragile marine ecological system. Therefore, facile large-scale synthesis hydrophobic three-dimensional (3-D) porous sorbents from low cost raw materials is in urgent demand. In this study, we report template-free polypropylene (PP) sponge using thermally-induced phase separation (TIPS) technique. The obtained showed...
Ice accretion on solid surfaces, a ubiquitous phenomenon that occurs in winter, brings much inconvenience to daily life and can even cause serious catastrophes. Icephobic passive way of processing surfaces prevent surface destruction from ice accumulation, have attracted attention scientists because their special ice-repellent properties, many efforts been made rationally design durable icephobic coatings. This review is aimed at providing brief crucial overview formation processes feasible...
Abstract Active tumor penetration has been recently recognized as a promising strategy to resolve the limitation of nanomedicine in terms penetration, but it is challenging develop active transporting nanocarriers. Here, an ultrasonic cavitation‐assisted and acid‐activatable liposome for broad range tumors reported. The (size charge dual‐conversional gemcitabine prodrug‐integrated liposomal nanodroplet (SCGLN)) overcomes tight blood vessel walls with aid cavitation. SCGLN subsequently...
Ligand/receptor-mediated targeted drug delivery has been widely recognized as a promising strategy for improving the clinical efficacy of nanomedicines but is attenuated by binding plasma protein on surface nanoparticles to form corona. Here, it shown that ultrasonic cavitation can be used unravel coronas liposomal through ultrasound (US)-induced reassembly. To demonstrate feasibility and effectiveness method, transcytosis-targeting-peptide-decorated reconfigurable liposomes (LPGLs) loaded...
Sonodynamic therapy (SDT) induces immunogenic cell death (ICD) in tumors and promises to play an assistive role immunotherapy pancreatic cancer. However, the short half-life limited diffusion distance of reactive oxygen species (ROS) impair ICD induction, especially with relatively poor blood perfusion dense stroma.To address this problem, we fabricated cavitation-assisted endoplasmic reticulum (ER) targeted sonodynamic nanodroplets (PMPS NDs, 329 nm). The good effect precise target was...
The continuous vital signs monitoring allows clinicians to timely assess the physiological conditions of patient in ICU. Internet Things (IoT) hospital that integrated various sensors (e.g. cameras) may enable intelligent healthcare. In this paper, we proposed a remote system exploits CCTV cameras an IoT infrastructure as optical for non-contact measurement, extending its scope from surveillance warding. implemented latest camera photoplethysmography algorithms cardio-respiratory...
A chemicobiology toolbox for type I and II photodynamic therapy.
A new strategy for preparation of 3-miktoarm star terpolymer was suggested. The fully-defined precursors PtBA-N3 (poly(tert-butyl acrylate) with azide end group), TEMPO-PEO or TEMPO-PCL (poly(ethylene oxide) poly(ε-caprolactone) TEMPO group) and PS-alkyne/Br (polystyrene ω-propargyl ω′-(2-bromoiso butyryl) groups) are designed prepared first, then the terpolymers composed PtBA, PS, PEO (PCL) arms could be obtained via combination "click chemistry" ATNRC reaction using a one-pot. [Color...
Glaser coupling reaction of alkynyl groups was used as a new ring-closure technique to synthesize monocyclic poly(ethylene oxide) (PEO) and polystyrene (PS) successfully. The linear PEO with hydroxyl at both ends prepared by ring-opening polymerization (ROP) ethylene oxide (EO) using 2,2-dimethyl-1,3-propanediol diphenylmethylpotassium (DPMK) co-initiators, terminated anhydrous methanol. PS anionic lithium naphthalenide initiator EO. propargyl-telechelic precursors (l-PEO l-PS) were then...
An amphiphilic heteroeight-shaped polymer cyclic-[poly(ethylene oxide)-b-polystyrene]2 ([c-(PEO-b-PS)]2) composed of hydrophilic PEO and hydrophobic PS blocks was synthesized by combination "click" chemistry with anionic ring-opening polymerization (ROP) atom transfer radical (ATRP) mechanisms. According to "core-first" strategy, the A2B2 star-shaped precursor (PEO-alkyne)2-(PS-N3)2 obtained successive ROP EO monomer, ATRP St modification functional groups. Under high dilution condition,...
Abstract Polymerization‐induced self‐assembly (PISA) and in situ crosslinking of the formed nanoparticles are successfully realized by activators regenerated electron‐transfer atom transfer radical polymerization (ARGET ATRP) glycidyl methacrylate (GMA) or a mixture GMA/benzyl (B n MA) monomers ethanol. Poly(oligo(ethylene oxide) methyl ether methacrylate) was employed as macroinitiator/stabilizer, cupric bromide/tris(pyridin‐2‐ylmethyl)amine complex catalyst. Tin (2‐ethylhexanoate) used...
The polymerization-induced self-assembly (PISA) has been developed with great success and rapidly promoted the application of technique in practice. living anionic polymerization (LAP) is represented as a paragon polymer chemistry because its versatility synthesis well-defined model polymers many advantages. However, combination LAP mechanism PISA process still rarely succeeded remains challenge. In this contribution, was realized by using diblock copolymer polyisoprene-b-polystyrene...
Inefficient intracellular gene release and transfection limit nonviral delivery applications in cancer therapy. Reactive oxygen species (ROS) responsive is the most widely explored strategy for such applications, yet development of fast safe ROS nanocarriers proves to be a challenge because chemical equilibrium high glutathione levels. Here, we report an ultrasound-enhanced charge-reversal polymeric nanocarrier (BTIL) efficient pancreatic delivery. The BTIL composed B-PDEAEA/DNA...
Ring-opening polymerization-induced self-assembly (ROPISA) was achieved by employing hydroxyl-terminated polyisobutylene (PIB-OH), diphenyl phosphate (DPP), cyclohexane, and ε-caprolactone (ε-CL) and/or δ-valerolactone (δ-VL) as the stabilizer/macroinitiator, catalyst, solvent, monomers, respectively. ROPISA has enabled introduction of biodegradable, biocompatible, crystallizable polylactones to nanoparticles related materials. The polymerization temperatures (20, 50, or 80 °C) had an...