A5100372260- Extracellular vesicles in disease
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Inflammasome and immune disorders
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- Coastal wetland ecosystem dynamics
- Genomics, phytochemicals, and oxidative stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoplatforms for cancer theranostics
- Vibrio bacteria research studies
- Venous Thromboembolism Diagnosis and Management
- Bacterial Genetics and Biotechnology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cell Adhesion Molecules Research
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Microbial metabolism and enzyme function
- Heavy metals in environment
- Antimicrobial Peptides and Activities
- Geophysical Methods and Applications
- Seismic Imaging and Inversion Techniques
- Invertebrate Immune Response Mechanisms
Heze Municipal Hospital
2024-2025
Nanjing Medical University
2023-2025
Shanghai Stomatological Hospital
2021-2024
Fudan University
2012-2024
Nanchang University
2024
Ludong University
2022-2024
Harbin Medical University
2022-2024
Sun Yat-sen University
2024
Fifth Affiliated Hospital of Sun Yat-sen University
2024
Southeast University
2024
Abstract Objectives Carcinoma-associated fibroblasts (CAFs) have been known to promote cancer progression by modifying the primary tumor microenvironment. We aimed elucidate intercellular communication between CAFs and secondary organs in salivary adenoid cystic carcinoma (SACC) metastasis. Methods Pre-metastatic metastatic animal models of SACC were established using extracellular vesicles (EVs) from cells. Lung (LFs) treated with EVs their transcriptomic alterations identified RNA...
Abstract Neuroinflammation has emerged as a major concern in ischemic stroke therapy because it exacebates neurological dysfunction and suppresses recovery after ischemia/reperfusion. Fingolimod hydrochloride (FTY720) is an FDA‐approved anti‐inflammatory drug which exhibits potential neuroprotective effects brain parenchyma. However, delivering sufficient amount of FTY720 through the blood–brain barrier into lesions without inducing severe cardiovascular side remains challenging. Here,...
Copper is an essential trace element for the human body, and its requirement optimistic immune functions has been recognized decades. How copper involved in innate pathway, however, remains to be clarified. Here, we report that serves as a signal molecule regulate kinase activity of alpha-kinase 1 (ALPK1), cytosolic pattern-recognition receptor (PRR), therefore promotes host cell defense against bacterial infection. We show response infection, cells actively accumulate cytosol, accumulated...
Abstract Carcinoma-associated fibroblasts (CAFs) are the main cellular components of tumor microenvironment and promote cancer progression by modifying extracellular matrix (ECM). The tumor-associated ECM is characterized collagen crosslinking catalyzed lysyl oxidase (LOX). Small vesicles (sEVs) mediate cell-cell communication. However, interactions between sEVs remain unclear. Here, we demonstrated that released from oral squamous cell carcinoma (OSCC)-derived CAFs induce crosslinking,...
Demyelinating diseases, such as multiple sclerosis, are known to result from acute or chronic injury the myelin sheath and inadequate remyelination; however, underlying molecular mechanisms remain unclear. Here, we performed genome occupancy analysis by chromatin immunoprecipitation sequencing in oligodendrocytes response lysolecithin-induced found that Olig2 its downstream target Gpr17 critical factors regulating oligodendrocyte survival. After oligodendrocytes, was significantly...
MicroRNAs are a class of non-coding RNAs that function as key regulators gene expression at the post-transcriptional level. In our previous research, we found miR-23a was significantly up-regulated in human gastric adenocarcinoma cells. current study, demonstrate suppresses paclitaxel-induced apoptosis and promotes cell proliferation colony formation ability We have identified tumor suppressor interferon regulator factor 1 (IRF1) direct target miR-23a. performed fluorescent reporter assay to...
Most bacteria replicate and segregate their DNA concomitantly while growing, before cell division takes place. How synchronize these different cycle events to ensure faithful chromosome inheritance by daughter cells is poorly understood. Here, we identify Cell Cycle Regulator protein interacting with FtsZ (CcrZ) as a conserved essential in pneumococci related Firmicutes such Bacillus subtilis Staphylococcus aureus. CcrZ couples replication controlling the activity of master initiator...
Cancer-associated fibroblasts (CAFs) are critically involved in tumor progression by maintaining extracellular mesenchyma (ECM) production and improving development. Cyclooxygenase-2 (COX-2) has been proved to promote ECM formation progression. However, the mechanisms of COX-2 mediated CAFs activation have not yet elucidated. Therefore, we conducted this study identify effects underlying tumor-derived exosomal miRNAs lung adenocarcinoma (LUAD) progression.As measures activation, expressions...
Melittin, the principal constituent in bee venom, is an attractive candidate for cancer therapy. However, its clinical applications are limited by hemolysis, nonspecific cytotoxicity, and rapid metabolism. Herein, a novel genetically engineered vesicular antibody-melittin (VAM) drug delivery platform was proposed validated targeted combination VAM generated from cellular plasma membrane bio-synthetically fabricated, with recombinant protein (hGC33 scFv-melittin) being harbored displayed on...
<h3>Abstract</h3> The cellular mechanisms underlying feedback signaling from horizontal cells to photoreceptors, which are important for the formation of receptive field surrounds early visual neurons, remain unsettled. Mammalian express a complement synaptic proteins that necessary and sufficient calcium-dependent exocytosis inhibitory neurotransmitters at their contacts with photoreceptor terminals, suggesting they capable releasing GABA via vesicular release. To test whether cell release...
Angiogenesis occurs during both physiological and pathological processes. In this study, a microfluidic chip for the development of angiogenesis was utilized to assess angiogenic sprouting functional vessel formation. We also found that vascular endothelial growth factor (VEGF) determinant initiation sprouts, while direction these sprouts greatly influenced by interstitial flow. Isoforms VEGF such as VEGF121, VEGF165, VEGF189 displayed different properties on assessed sprout length number,...
cGAS plays an important role in regulating both tumor immune responses and DNA damage repair. Nevertheless, there was little research that comprehensively analyzed the correlation between microenvironment, cell infiltration, repair different cancers. In this study, The Cancer Genome Atlas (TCGA) Cell Line Encyclopedia (CCLE) data were used to analyze mRNA expression genomic alterations of pan-cancer. HPA database explore protein levels normal tissues Correlation analysis performed interferon...
Chemoresistance poses a significant challenge in colorectal cancer (CRC) treatment. However, the mechanisms underlying chemoresistance remain unclear. CBX3 promoted proliferation and metastasis CRC. role mechanism of unknown. Therefore, we aimed to investigate effects on multidrug resistance Our studies showed that higher levels expression were associated with poor survival, especially groups progression following chemotherapy. overexpression increased Irinotecan Oxaliplatin resistance,...
Abstract Background: MUC1 is frequently overexpressed in various human epithelial cancers, including NSCLC, gastrointestinal, breast, pancreatic, ovarian, and colon carcinomas. Despite the development of targeted therapies, none have shown significant clinical efficacy. BGB-B3227, a novel bispecific antibody targeting CD16A, designed to induce NK cell activation subsequent cytotoxicity against MUC1-expressing tumor cells. Methods: The target binding activity BGB-B3227 was characterized using...
The N6-methyladenosine (m6A) modification is the most prevalent of eukaryotic mRNAs and plays a crucial role in various physiological processes by regulating stability or function target mRNAs. Accumulating evidence has suggested that m6A methylation may be involved pathological process major depressive disorder (MDD), common neuropsychiatric with an unclear aetiology. Here, we found levels circular RNA HECW2 (circHECW2) were significantly increased plasma both MDD patients chronic...
Vascular endothelial growth factor (VEGF) is an important proangiogenic and has been considered as a key target of antiangiogenetic therapy in oral squamous cell carcinoma (OSCC). However, clinical application bevacizumab, specific VEGF antibody, didn't improve the survival rate OSCC patients. One possible explanation that gene expresses diverse isoforms, which associate with extracellular vesicles (EVs), EVs potentially contribute to resistance bevacizumab. clear solution lacking addressing...
As post-transcriptional regulators, microRNAs (miRNAs) play an important role in growth and reproductive processes. So far, there is limited information regarding crustacean miRNAs. To explore the potential of miRNAs gonadal development prawn Macrobrachium rosenbergii, we constructed seven small RNA libraries from ovarian testicular tissues at various stages using somatic tissue as control. A total 1,954 known 129 novel were retrieved. By comparing differentially expressed (DEMs) between...
Distant metastasis remains the primary cause of treatment failure and suggests a poor prognosis in nasopharyngeal carcinoma (NPC). Epithelial-mesenchymal transition (EMT) is critical cellular process for initiating tumor invasion remote metastasis. Our previous study showed that blockage stromal interaction molecule 1 (STIM1)-mediated Ca2+ signaling blunts Epstein-Barr virus (EBV)-promoted cell migration inhibits dissemination lymphatic NPC cells. However, upstream pathway regulates STIM1...
Abstract Oesophageal cancer (EC) is a malignancy which accounts for substantial number of cancer‐related deaths worldwide. The molecular mechanisms underlying the pathogenesis EC have not been fully elucidated. GSE17351 and GSE20347 data sets from Gene Expression Omnibus (GEO) database were employed to screen differentially expressed genes (DEGs). Reverse transcription quantitative PCR (RT‐qPCR) was used examine hub gene expression. ECA‐109 TE‐12 cells transfected using pcDNA3.1 expression...