A5100654229- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Sleep and related disorders
- Sleep and Work-Related Fatigue
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- Epigenetics and DNA Methylation
- Luminescence and Fluorescent Materials
- Graphene and Nanomaterials Applications
- Ultrasound and Hyperthermia Applications
- Sleep and Wakefulness Research
- Photoacoustic and Ultrasonic Imaging
- Global Cancer Incidence and Screening
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- dental development and anomalies
- Healthcare and Venom Research
- MicroRNA in disease regulation
- Immune cells in cancer
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
Hubei University of Chinese Medicine
2024-2025
Peking University
2023-2025
Peking University Third Hospital
2023-2025
Xiamen University
2020-2024
Nanjing Medical University
2020-2024
Tongji University
2017-2023
Shanghai Stomatological Hospital
2022-2023
Zhongnan University of Economics and Law
2023
Southwest Jiaotong University
2020-2023
Second Military Medical University
2020-2022
Periodontitis is the sixth most prevalent diseases around globe, which closely related to many systemic and affects general health. As leading cause of tooth loss, periodontitis characterized by irreversible alveolar bone loss activated osteoclastogenic process, might be intracellular reactive oxygen species (ROS) in osteoclasts. Here, we demonstrated triggering receptor expressed on myeloid cells 2 (Trem2) as a key regulator osteoclastogenesis with regulation ROS signals periodontitis. In...
Although water-soluble graphene quantum dots (GQDs) have shown various promising bio-applications due to their intriguing optical and chemical properties, the large heterogeneity in compositions, sizes, shapes of these GQDs hampers better understanding structure-properties correlation further uses terms large-scale manufacturing practices safety concerns. It is here that a atomically-precise GQD (WAGQD-C
The treatment of pancreatic cancer faces significant challenges due to connective tissue hyperplasia and severe hypoxia. Unlike oxygen-dependent Type II photosensitizers, I photosensitizers can produce a substantial amount reactive oxygen species, even under hypoxic conditions, making them more suitable for photodynamic therapy cancer. However, the dense extracellular matrix limits penetration efficiency presence immunosuppressive cells in tumor microenvironment reduces therapeutic effect....
Abstract Improved drug loading content, bioavailability, and controlled release in targeted tissue have been major bottlenecks the design of precision nanomedicine. Herein, a tumor‐specific multiple‐stimuli responsive nano‐riceball is proposed validated for enhanced sono‐chemotherapy. The (NGR@DDP) possesses well‐designed core‐shell structure, formed by an inner core assembly that contains ultrasound/H 2 O bottlebrush‐like unimolecular dextran‐POEGMA 9 ‐ b ‐PMTEMA 22 (DOS) with co‐loaded...
Abstract Bone regeneration originates from proliferation and differentiation of osteoprogenitors via either endochondral or intramembranous ossification; the capacities decline with age estrogen loss. Maxillary sinus floor lifting (MSFL) is a commonly used surgical procedure for guiding bone in maxilla. Radiographic analysis 1210 clinical cases maxilla after MSFL revealed that intrasinus osteogenic efficacy was independent gender, however; this might be related to Schneiderian membrane lines...
Abstract Precise anti‐cancer therapy is hampered by aberrant tumor microenvironments (TME), which include the important features of dense extracellular matrix (ECM) and hypoxia. The capability hyaluronidase (HAase) to degrade hyaluronic acid (HA), main component ECM, can prompt its rapid development in sonotherapeutics aimed at regulating microenvironment. In this study, authors design a bioengineering‐based smart enzymatic nanovesicle mHAase combined with purpurin 18 (P18) form mHAase@nP18...
Background/Aims: Obesity contributes to the development of cardiometabolic disorders such as type 2 diabetes, fatty liver disease and cardiovascular disease. Salvianolic acid B (Sal B) is a molecule derived from root Salvia miltiorrhiza (Danshen), which traditional Chinese medicine that widely used treat diseases. However, role Sal in obesity obesity-related metabolic unknown. In this study, we aimed investigate effects on high-fat diet-induced determine possible mechanisms involved....
Melittin, the principal constituent in bee venom, is an attractive candidate for cancer therapy. However, its clinical applications are limited by hemolysis, nonspecific cytotoxicity, and rapid metabolism. Herein, a novel genetically engineered vesicular antibody-melittin (VAM) drug delivery platform was proposed validated targeted combination VAM generated from cellular plasma membrane bio-synthetically fabricated, with recombinant protein (hGC33 scFv-melittin) being harbored displayed on...
Accurate diagnosis and effective treatment of primary liver tumors are great significance, optical imaging has been widely employed in clinical imaging-guided surgery for tumors. The second near-infrared window (NIR-II) emissive AIEgen photosensitizers have attracted a lot attention with higher-resolution bioimaging deeper penetration. NIR-II aggregation-induced emission-based luminogen (AIEgen) better phototherapeutic effects accuracy the image-guided surgery/phototherapy. Herein, an...
Abstract Objective Gastric cancer (GC) is one of the most prevalent malignant tumors in Asian countries. Studies have proposed that lncRNAs can be used as diagnostic and prognostic indicators GC due to high specificity expression involvement GC. Recently, N6-methyladenosine (m6A) has also emerged an important modulator This study aimed at establishing a novel m6A-related signature construct accurate models for predicting prognosis population. Methods First, levels m6A modification...
Degenerative changes in the skeleton play an important role ageing. As foremost sensors and orchestrators of bone remodelling, osteocytes contribute significantly to health skeleton. Embedded a mineralized matrix, osteocyte network surrounding lacunar canaliculae work together as functional syncytium-the osteocytic lacunar-canalicular system (OLCS). However, OLCS during ageing related mechanisms cannot be fully understood by using traditional histological analysis.To link phenotypes aged...
Mild cognitive impairment (MCI) is a symptomatic predementia phase of the trajectory decline, and its prevalence increases with age. Although relationship between oral health MCI have been explored previously, it uncertain whether individuals different tooth loss rates altered risks. We hereby conducted longitudinal study by using data from Chinese Longitudinal Healthy Longevity Survey to investigate association. Tooth rate was defined as difference teeth two interview waves divided years...
Microbubbles are widely used as ultrasound contrast agents owing to their excellent echoing characteristics under radiation. However, short sonographic duration and wide size distribution still hinder application. Herein, we present a hard-template approach produce perfluoropropane-loaded cerasomal microbubbles (PLCMs) with uniform long duration. The preparation of PLCMs includes deposition Si-lipids onto functionalized CaCO3 microspheres, removal cores mild infusion perfluoropropane. In...
BMMSC-derived exosomes from rats with bone deterioration increased the osteoclastogenesis of Raw264.7 cells, which suggests that could accelerate in alveolar deterioration.
Abstract Recurrent pregnancy loss (RPL) rates have continued to rise during the last few decades, yet underlying mechanisms remain poorly understood. An emerging area of interest is mediation gene expression by DNA methylation early pregnancy. Here, genome‐wide from placental villi was profiled in both RPL patients and controls. Subsequently, differentially expressed genes were analysed for changes expression. Many significant methylated regions (DMRs) identified near dysregulated including...
Abstract Background Globally, gastrointestinal (GI) cancer is one of the most prevalent malignant tumors. However, studies have not established glycolysis-related gene signatures that can be used to construct accurate prognostic models for GI cancers in Asian population. Herein, we aimed at establishing a novel expression signature predict prognosis cancers. Methods First, evaluated mRNA profiles and corresponding clinical data 296 patients The Cancer Genome Atlas (TCGA) database (TCGA-LIHC,...
Immunotherapy as a milestone in cancer treatment has made great strides the past decade, but it is still limited by low immune response rates and immune-related adverse events. Utilizing bioeffects of ultrasound to enhance tumor immunotherapy attracted more attention, including sonothermal, sonomechanical, sonodynamic sonopiezoelectric immunotherapy. Moreover, emergence nanomaterials further improved efficacy mediated However, most summaries this field are about single aspect biological...